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| 名称 | 22RV1 (人前列腺癌细胞) (STR鉴定正确) |
| 别称 | 22RV1; 22Rv-1; 22rV1; CWR22-Rv1; CWR22R-V1; CWR22-R1; CWR22Rv1; CWR22R |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：90%FBS+10%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 22RV1细胞复苏时需要离心去除DMSO。冻存细胞复苏最初阶段，贴壁量少，成簇松散贴壁，但是最终细胞会变平并且扩散成很好的单层，这个过程需要4-5天时间。细胞生长缓慢，细胞只能生长到90%的汇合度。细胞冻存后复苏成活率不高，推荐冻存液配比为90%FBS+10% DMSO，使用优质血清。 |
| 背景描述 | 22RV1是来自异种移植(在阉割引起前列腺癌衰退又在其父亲的雄性激素信赖型CWR22嫁接后复发的小鼠中连续传代)的人前列腺癌上皮细胞系；22RV1细胞系表达前列腺特异抗原。二羟基睾丸脂酮轻微刺激22RV1细胞生长，经Western Blot检测溶解产物与抗雄性激素受体抗体起免疫反应；EGF刺激22RV1细胞生长，但TGFβ-1不能抑制细胞生长；22RV1可在裸鼠中成瘤。 |
| 年龄（性别） | 男性 |
| 组织来源 | 前列腺 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 前列腺癌细胞 |
| 生物安全等级 | BSL-2 |
| 倍增时间 | ~40 hours |
| 致瘤性 | Yes, forms tumors in nude mice. |
| 受体表达情况 | androgen receptor |
| 保藏机构 | ATCC; CRL-2505 BCRC; 60545 DSMZ; ACC-438 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,11 D2S1338 17,18 D3S1358 15 D5S818 11,13 D7S820 9,10,11 D8S1179 13,14 D13S317 9,12 D16S539 12 D18S51 13,14 D19S433 13,14 D21S11 30 FGA 19,23 PentaD 9,12 PentaE 5,13 TH01 6,9.3 TPOX 8 vWA 15,21 D6S1043 16 D12S391 18,25 D2S441 11,12 -
STR鉴定图
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参考文献
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Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer(2024/03/21)
作者：Da Ren, Wei Li, Ruijiang Zeng
期刊：CELL DEATH AND DIFFERENTIATION
DOI：10.1038/s41418-024-01282-w
影响因子 ：12.400
引用产品：CL-0004
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Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer(2022/09/01)
作者：Shidong Lv, Zeyu Wu, Mayao Luo
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-05182-0
影响因子 ：9.000
-
Tautomycin and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer(2022/11/29)
作者：Luo, Mayao, Zhang, Yifan, Xu, Zhuofan, Wu, Chenwei, Ye, Yuedian, Liu, Rui, Lv, Shidong, Wei, Qiang
期刊：Cell Death Discovery
DOI：10.1038/s41420-022-01257-1
影响因子 ：7.000
-
Synthesis and bioactivity evaluation of ferrocene-based hydroxamic acids as selective histone deacetylase 6 inhibitors(2022/12/07)
作者：Jiangkun Yan, Kairui Yue, Xuejing Fan
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2022.115004
影响因子 ：6.700
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AID-induced CXCL12 upregulation enhances castration-resistant prostate cancer cell metastasis by stabilizing β-catenin expression(2023/11/23)
作者：Qi Li, Jinfeng Fan, Zhiyan Zhou
期刊：iScience
DOI：10.1016/j.isci.2023.108523
影响因子 ：5.800
引用产品：CL-0004
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A Liquid–Liquid Phase Separation-Related Index Associate with Biochemical Recurrence and Tumor Immune Environment of Prostate Cancer Patients(2023/03/14)
作者：Qi You, Jiayin Chen, Xiaohui Wu
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
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LOC100996425 acts as a promoter in prostate cancer by mediating hepatocyte nuclear factor 4A and the AMPK/mTOR pathway(2021/08/19)
作者：Xiuyan Wang, Bin Song, Mingcui Zang
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.300
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MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways(2021/11/10)
作者：Sihai Zhou, Zhihong Dai, Liang Wang
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.295
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177Lu-Labeled Bivalent Ligands of Prostate-Specific Membrane Antigen for Endoradiotherapy of Prostate Cancer(2023/12/28)
作者：Ruoxue Dai, Zhikai Cai, Rui Hu
期刊：MOLECULAR PHARMACEUTICS
DOI：10.1021/acs.molpharmaceut.3c00987
影响因子 ：4.900
引用产品：CL-0004
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YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation(2024/03/09)
作者：Xuefeng Zhao, Suli Lv, Neng Li
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 ：4.800
引用产品：CL-0004
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Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer(2023/08/16)
作者：Hongzhuang Wen, Changbao Qu, Zhu Wang
期刊：FASEB JOURNAL
影响因子 ：4.800
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Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression(2022/10/17)
作者：Anning Zhao, Zhan Yang, Dandan Wang
期刊：FASEB JOURNAL
影响因子 ：4.800
引用产品：CL-0004
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USF1-mediated ALKBH5 stabilizes FLII mRNA in an m6A-YTHDF2-dependent manner to repress glycolytic activity in prostate adenocarcinoma(2023/07/26)
作者：Dewang Fu, Qingyue Si, Chenxi Yu
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23609
影响因子 ：4.600
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Epigenetic activation of METTL14 promotes docetaxel resistance in prostate cancer by promoting pri-microRNA-129 maturation(2024/03/28)
作者：Cheng Wu, Chunqing Miao, Songlin Zhou
期刊：ENVIRONMENTAL TOXICOLOGY
影响因子 ：4.500
引用产品：CL-0004
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HMGB1 promotes the development of castration‑resistant prostate cancer by regulating androgen receptor activation(2022/09/19)
作者：Junyu Chen, Duo Xu, Taiwei Wang
期刊：ONCOLOGY REPORTS
影响因子 ：4.200
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Crafting a Personalized Prognostic Model for Malignant Prostate Cancer Patients Using Risk Gene Signatures Discovered through TCGA-PRAD Mining, Machine Learning, and Single-Cell RNA-Sequencing(2023/06/07)
作者：Feng Lyu, Xianshu Gao, Mingwei Ma
期刊：Diagnostics
DOI：10.3390/diagnostics13121997
影响因子 ：3.600
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IU1 and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer(2023/08/07)
作者：Yifan Zhang, Yuanpeng Liao, Mayao Luo
期刊：PROSTATE
影响因子 ：2.800
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GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer(2022/10/25)
作者：Ming Yang, Xudong Zhu, Yang Shen
期刊：PeerJ
影响因子 ：2.700
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Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer(2023/04/12)
作者：Qingfu Zhang, Peng Zhang, Zhongting Zhao
期刊：PeerJ
影响因子 ：2.700
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Circular RNA Dipeptidyl Peptidase 4 (circDPP4) Stimulates the Expression of Glutamate Dehydrogenase 1 to Contribute to the Malignant Phenotypes of Prostate Cancer by Sponging miR-497-5p(2023/04/20)
作者：Long Pei, Xiaosen Song, Xiangdong Liang
期刊：MOLECULAR BIOTECHNOLOGY
DOI：10.1007/s12033-023-00750-x
影响因子 ：2.600
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A morpholine derivative N-(4-morpholinomethylene)ethanesulfonamide induces ferroptosis in tumor cells by targeting NRF2(2024/01/30)
作者：Bingchun Sun, Ligang Zhang, Binhua Wu
期刊：BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子 ：2.000
引用产品：CL-0004
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Synthesis of curcumin derivatives for suppression of castration-resistant prostate cancer(2024/02/06)
作者：Shunze Gong, Chixiang Yuan, Hang Hu
期刊：JOURNAL OF CHEMICAL RESEARCH
影响因子 ：1.400
引用产品：CL-0004
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