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产品概述
| 名称 | ARPE-19 (人视网膜上皮细胞) (STR鉴定正确) |
| 别称 | ARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 年龄（性别） | 男性；19岁 |
| 组织来源 | 眼睛，视网膜 |
| 细胞类型 | 自发永生化细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~55-65 hours |
| 基因表达情况 | RPE-specific markers CRALBP and RPE-65 |
| 保藏机构 | ATCC; CRL-2302 BCRC; 60383 BCRJ; 0041 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 11 D2S1338 19 D3S1358 14,15 D5S818 13 D7S820 9,11 D8S1179 13 D13S317 11,12 D16S539 9,11 D18S51 12,16 D19S433 12,13 D21S11 28,29 FGA 23 PentaD 11,13 PentaE 7,11 TH01 6,9.3 TPOX 9,11 vWA 16,19 D6S1043 17,19 D12S391 21,22 D2S441 10,15 -
STR鉴定图
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参考文献
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Extracellular vesicles from organoid-derived human retinal progenitor cells prevent lipid overload-induced retinal pigment epithelium injury by regulating fatty acid metabolism(2023/12/27)
作者：Hui Gao, Yuxiao Zeng, Xiaona Huang
期刊：Journal of Extracellular Vesicles
影响因子 ：16.000
引用产品：CL-0026
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Aligned Nanofibers from Polypyrrole/Graphene as Electrodes for Regeneration of Optic Nerve via Electrical Stimulation(2016/03/09)
作者：Lu Yan, Bingxin Zhao, Xiaohong Liu
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
引用产品：CL-0026
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PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation(2023/01/23)
作者：Bo Liu, Xueting Yao, Chaoyang Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05590-w
影响因子 ：9.000
引用产品：CL-0026
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MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells(2021/07/15)
作者：Shuhua Fu, Meichen Lai, Yunyao Zheng
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03956-6
影响因子 ：9.000
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Development of Uveal Melanoma-Specific Aptamer for Potential Biomarker Discovery and Targeted Drug Delivery(2023/02/22)
作者：Zhaoqi Pan, Hui Zhu, Yibin Zhang
期刊：Analytical Chemistry
DOI：10.1021/acs.analchem.3c00005
影响因子 ：7.400
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Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk sequencing data(2023/01/30)
作者：Wanpeng Wang, Han Zhao, Sha Wang
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1099071
影响因子 ：7.300
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Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization(2021/05/06)
作者：Mengyuan Fang, Wencui Wan, Qiuming Li
期刊：Life Sciences
影响因子 ：6.780
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ERp29 Attenuates Nicotine-Induced Endoplasmic Reticulum Stress and Inhibits Choroidal Neovascularization(2023/10/24)
作者：Tu Lu, Fangfang Xie, Chuangxin Huang
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
引用产品：CL-0026
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Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2(2022/03/18)
作者：Xuyuan Tang, Xiuyi Li, Dongyan Zhang
期刊：Bioengineered
DOI：10.1080/21655979.2022.2049471
影响因子 ：4.900
引用产品：CL-0026
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CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells(2024/05/14)
作者：Rong Zhang, Lin Wang, Yang Li
期刊：Human Cell
DOI：10.1007/s13577-024-01075-w
影响因子 ：4.300
引用产品：CL-0026
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Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina(2024/03/15)
作者：Jian Tan, Ang Xiao, Lin Yang
期刊：World Journal of Diabetes
影响因子 ：4.200
引用产品：CL-0026
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Gambogic acid ameliorates high glucose– and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo(2020/11/27)
作者：Jun Chen, Lihua Li, Yun Zhou
期刊：Cell Stress & Chaperones
DOI：10.1007/s12192-020-01182-1
影响因子 ：3.800
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Exome sequencing reveals PPEF2 variant associated with high myopia(2023/12/16)
作者：Sili Jing, Xianglong Yi
期刊：GENE
DOI：10.1016/j.gene.2023.148091
影响因子 ：3.500
引用产品：CL-0026
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Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment(2022/03/21)
作者：Xinli Jiang, Yan Liu, Yuling Wang
期刊：Molecular Medicine Reports
影响因子 ：3.423
引用产品：CL-0026
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GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis(2024/04/16)
作者：Xiaoxiang Xu, Xihui Ding, Zizhuo Wang
期刊：MICROVASCULAR RESEARCH
影响因子 ：3.100
引用产品：CL-0026
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Hsa_circ_0000527 Downregulation Suppresses the Development of Retinoblastoma by Modulating the miR-27a-3p/HDAC9 Pathway(2021/11/25)
作者：Xiangrong Zuo, Changjiang Fu, Jing Xie
期刊：Current Eye Research
DOI：10.1080/02713683.2021.1925697
影响因子 ：2.000
引用产品：CL-0026
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Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway(2023/10/26)
作者：Wenyi Zhang, Jing Yao, Chen Chen
期刊：CURRENT EYE RESEARCH
DOI：10.1080/02713683.2023.2276683
影响因子 ：2.000
引用产品：CL-0026
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Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells(2019/4/18)
作者：Rong Li, Junhui Du, Guomin Yao
期刊：International Journal of Ophthalmology
影响因子 ：1.400
引用产品：CL-0026
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All-trans retinoic acid regulates the expression of MMP-2 and TGF-β2 via RDH5 in retinal pigment epithelium cells(2023/06/18)
作者：Yumei Mao, Changjun Lan, Qingqing Tan
期刊：International Journal of Ophthalmology
影响因子 ：1.400
引用产品：CL-0026
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Autophagy dysregulation mediates the damage of high glucose to retinal pigment epithelium cells(2021/6/18)
作者：Qian Zhang, Hongsong Li, Rong Li
期刊：International Journal of Ophthalmology
影响因子 ：1.400
引用产品：CL-0026
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Fundus-Vascular Responses to Color Deviation Caused by Non-Oxidative Blue Filtering(2022/10/12)
作者：Jianqi Cai, Wentao Hao, Shanshan Zeng
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.000
引用产品：CL-0026
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GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells(2022/03/29)
作者： Fang Li, Qinyun Xia, Lian Ren
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.000
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