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![NCI-N87 [N87] (人胃癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0169-1.jpg)
![NCI-N87 [N87] (人胃癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0169-2.jpg)
![NCI-N87 [N87] (人胃癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0169-3.jpg)
![NCI-N87 [N87] (人胃癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0169-4.jpg)
![NCI-N87 [N87] (人胃癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0169-5.jpg)
![NCI-N87 [N87] (人胃癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0169-6.jpg)
![NCI-N87 [N87] (人胃癌细胞) (STR鉴定正确)](/Public/upfile/pic/product/cell-line-new.jpg)
产品概述
| 名称 | NCI-N87 [N87] (人胃癌细胞) (STR鉴定正确) |
| 别称 | NCI-N87 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:3 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | NCI-N87细胞表达表面糖蛋白癌胚抗原(CEA)和TAG72，并且没有左旋多巴胺脱羧酶(DDC)活性。NCI-N87细胞的血管活性的肠肽(VIP)受体活性极低并缺乏胃泌激素受体，它们表达蕈毒碱胆碱受体。没有证据表明，NCI-N87细胞存在N-myc、L-myc、myb和EGF受体基因的重组。NCI-N87细胞表达的c-myc和c-erb-B2 RNA水平与其它细胞株相当。以下基因NCI-N87细胞不表达：N-myc、L-myc、c-cis、IGF-2或胃泌激素释放肽。据报道，NCI-N87细胞的植板率为4.3%。 |
| 年龄（性别） | 男性 |
| 组织来源 | 胃癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胃癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~48-80 hours |
| 致瘤性 | Yes, the cells form tumors in athymic nude mice. |
| 受体表达情况 | acetylcholine, muscarinic, expressed |
| 保藏机构 | ATCC; CRL-5822 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 8,12 D2S1338 23,24 D3S1358 14 D5S818 12,13 D7S820 10,11 D8S1179 14 D13S317 8,11 D16S539 9,13 D18S51 17 D19S433 14,14.2 D21S11 30 FGA 20,21 PentaD 12 PentaE 5 TH01 9 TPOX 9,11 vWA 15,16 D6S1043 12 D12S391 16,21 D2S441 11,12 -
STR鉴定图
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参考文献
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RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer(2019/10/21)
作者：Yang Yu, Lei Chen, Guiping Zhao
期刊：Oncogene
影响因子 ：8.756
引用产品：CL-0169
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Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes(2024/01/06)
作者：Lixian Ding, Shuwei Dang, Mingjun Sun
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.01.002
影响因子 ：7.400
引用产品：CL-0169
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Isorhamnetin Promotes MKN-45 Gastric Cancer Cell Apoptosis by Inhibiting PI3K-Mediated Adaptive Autophagy in a Hypoxic Environment(2021/07/16)
作者：Chenghao Li, Jiawei Li, Yan Li
期刊：Journal Of Agricultural And Food Chemistry
影响因子 ：6.100
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Tumor-Derived Exosomal LINC01480 Upregulates VCAM1 Expression by Acting as a Competitive Endogenous RNA of miR-204-5p to Promote Gastric Cancer Progression(2023/12/22)
作者：Yu Zhang, Shan Guo, Tao Mao
期刊：ACS Biomaterials Science & Engineering
DOI：10.1021/acsbiomaterials.3c00394
影响因子 ：5.800
引用产品：CL-0169
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ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis(2024/05/23)
作者：Jiancheng He, Jianfeng Yi, Li Ji
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-024-00832-9
影响因子 ：5.700
引用产品：CL-0169
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Circ_0021087 acts as a miR-184 sponge and represses gastric cancer progression by adsorbing miR-184 and elevating FOSB expression(2021/06/02)
作者：Yin Yu, Hong Li, Chunhua Wu
期刊：European Journal Of Clinical Investigation
影响因子 ：5.500
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Long noncoding RNA PSMA3-AS1 functions as a competing endogenous RNA to promote gastric cancer progression by regulating the miR-329-3p/ALDOA axis(2023/07/04)
作者：Liang Kan, Meiqi Yang, Huijing Zhang
期刊：Biology Direct
DOI：10.1186/s13062-023-00392-8
影响因子 ：5.500
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LINC01354 enhances the metastatic ability of gastric cancer cells by adjusting miR-153-5p/CADM2 expression(2023/06/15)
作者：Fa Fang, Yin Gu, Jie Gao
期刊：American Journal of Cancer Research
DOI：PMID:37424819
影响因子 ：5.300
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ESM1 Interacts with c-Met to Promote Gastric Cancer Peritoneal Metastasis by Inducing Angiogenesis(2023/12/30)
作者：Jiaoyang Yang, Gege Shu, Tao Chen
期刊：Cancers
影响因子 ：5.200
引用产品：CL-0169
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Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase(2023/09/28)
作者：Minghui Liu, Shibo Sun, Yao Meng
期刊：MOLECULES
影响因子 ：4.600
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Pyrotinib treatment on HER2-positive gastric cancer cells promotes the released exosomes to enhance endothelial cell progression, which can be counteracted by apatinib(2019/3/12)
作者：Zhengxing Gao, Chunqing Song, Guangxin Li
期刊：Onco Targets and Therapy
影响因子 ：4.000
引用产品：CL-0169
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Suppression of gastric cancer cell proliferation by miR-494-3p inhibitor-loaded engineered exosomes(2024/05/06)
作者：Limin Zhang, Yingwei Xue, Hongfeng Zhang
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e30803
影响因子 ：4.000
引用产品：CL-0169
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Silencing of Nudix type 5 represses proliferation and invasion and enhances chemosensitivity of gastric carcinoma cells by affecting the AKT/GSK-3β/β-catenin pathway(2022/03/02)
作者：Dong Tan, Yafei Zhang
期刊：Toxicology And Applied Pharmacology
DOI：10.1016/j.taap.2022.115968
影响因子 ：3.800
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YTHDF2 promotes gastric cancer progression and enhances chemoradiotherapy resistance(2024/04/14)
作者：Jian Yang, Yawen Chen, Yang He
期刊：DRUG DEVELOPMENT RESEARCH
影响因子 ：3.800
引用产品：CL-0169
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ZNF521/EBF1 axis regulates AKR1B1 to promote the proliferation, migration, and invasion of gastric cancer cells(2022/11/17)
作者：Yu Cheng, Yi-Jiang Ni, Li-Ming Tang
期刊：KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
影响因子 ：3.300
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Homeobox Protein BarH-like 1 Promotes Gastric Cancer Progression by Activating Coiled-Coil Domain-Containing Protein 178(2024/02/15)
作者：Yue Gu, Gang Chen, Xinwei Ning
期刊：DIGESTIVE DISEASES AND SCIENCES
DOI：10.1007/s10620-024-08312-0
影响因子 ：3.100
引用产品：CL-0169
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Knockdown of Serum- and Glucocorticoid-Regulated Kinase 1 Enhances Cisplatin Sensitivity of Gastric Cancer Through Suppressing the Nuclear Factor Kappa-B Signaling Pathway.(2021/11/01)
作者：Jishui Zhang, Wenhao Lv, Yagang Liu
期刊：Balkan Medical Journal
DOI：10.5152/balkanmedj.2021.21114
影响因子 ：3.000
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KBTBD2 promotes proliferation and migration of gastric cancer via activating EGFR signaling pathway(2024/01/04)
作者：Jishuang Ding, Wei Gao, Haiying Yang
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.800
引用产品：CL-0169
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Oncogenic transmembrane protein 158 drives the PI3K/Akt signaling pathway to accelerate gastric cancer cell growth(2023/11/13)
作者：Xiaoting Cui, Jie Lu, Cuijuan Zhao
期刊：BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
DOI：10.1590/1414-431X2023e12943
影响因子 ：2.300
引用产品：CL-0169
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Celastrol inhibits gastric cancer cell proliferation, migration, and invasion via the FOXA1/CLDN4 axis(2023/04/20)
作者：Peng Wei, Chen Lin, Liu Jie
期刊：Toxicology Research
影响因子 ：2.100
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Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer(2022/11/30)
作者：Shuai Li, Yulian Ma, Chen Wu, Xinfang Hou, Shuai Li, Yulian Ma, Chen Wu, Xinfang Hou
期刊：HISTOLOGY AND HISTOPATHOLOGY
影响因子 ：2.000
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