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产品概述
| 名称 | HMC3 (人小胶质细胞) (STR鉴定正确) |
| 别称 | Human Microglia Clone 3 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:8 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | The HMC3 cell line was established through SV40-dependent immortalization of a human fetal brain-derived primary microglia culture. |
| 年龄（性别） | 胚胎 |
| 组织来源 | 脑组织 |
| 细胞类型 | 转化细胞系 |
| 生物安全等级 | BSL-2 |
| 保藏机构 | ATCC; CRL-3304 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,11 D2S1338 17,25 D3S1358 16,18 D5S818 11,12 D7S820 9,11 D8S1179 13,14 D13S317 11 D16S539 12,13 D18S51 18 D19S433 15,15.2 D21S11 30,31.2 FGA 21,25 PentaD 10,14 PentaE 7,13 TH01 6 TPOX 8,9 vWA 17,19 D6S1043 11 D12S391 16,21 D2S441 11,11.3 -
STR鉴定图
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参考文献
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Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system(2023/06/22)
作者：Peng Wang, Lin Jin, Min Zhang
期刊：Nature Biomedical Engineering
DOI：10.1038/s41551-023-01054-w
影响因子 ：28.100
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Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia(2024/03/30)
作者：Han Xie, Yanyi Jiang, Yufei Xiang
期刊：NEURO-ONCOLOGY
影响因子 ：15.900
引用产品：CL-0620
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Nanoplastic Stimulates the Amyloidogenesis of Parkinsons Alpha-Synuclein NACore(2023/11/21)
作者：Xiufang Liang, Nicholas Andrikopoulos
期刊：Small
影响因子 ：13.300
引用产品：CL-0620
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Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination(2023/03/25)
作者：Yumeng Wang, Jingxian Sun, Keying Zhu
期刊：Journal of Neuroinflammation
DOI：10.1186/s12974-023-02764-3
影响因子 ：9.300
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Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line(2022/09/23)
作者：Ying Tu, Yongyong Yang, Yue Wang
期刊：ENVIRONMENTAL POLLUTION
DOI：10.1016/j.envpol.2022.120217
影响因子 ：8.900
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SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights(2024/04/09)
作者：Ren Geng, Yao Zhao, Wanzhen Xu
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-024-05149-z
影响因子 ：7.400
引用产品：CL-0620
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PM2.5 exposure upregulates pro-inflammatory protein expression in human microglial cells via oxidant stress and TLR4/NF-κB pathway(2024/04/23)
作者：Ling Zhang, Fei Xu, Yishu Yang
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2024.116386
影响因子 ：6.800
引用产品：CL-0620
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TMEM16F may be a new therapeutic target for Alzheimer’s disease(2022/08/02)
作者：Zhiqiang Cui, Xiaoying Hu, Tuo Yang
期刊：Neural Regeneration Research
影响因子 ：6.100
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Microglia-endothelial cross-talk regulates diabetes-induced retinal vascular dysfunction through remodeling inflammatory microenvironment(2024/02/06)
作者：Shuai Ben, Yan Ma, Yun Bai
期刊：iScience
DOI：10.1016/j.isci.2024.109145
影响因子 ：5.800
引用产品：CL-0620
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lncRNA SND1-IT1 delivered via intracerebral hemorrhage-derived exosomes affect the growth of human microglia by regulating the miR-124-3p/MTF1 axis(2022/12/22)
作者：Jian Wang, Fei Teng, Shuhan Liu
期刊：JOURNAL OF CELLULAR PHYSIOLOGY
影响因子 ：5.600
引用产品：CL-0620
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α-Synuclein Induces Neuroinflammation Injury through the IL6ST-AS/STAT3/HIF-1α Axis(2023/01/11)
作者：Danyu Lin, Han Zhang, Jieli Zhang
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
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BAFF deficiency aggravated optic nerve crush-induced retinal ganglion cells damage by regulating apoptosis and neuroinflammation via NF-κB-IκBα signaling(2023/12/04)
作者：Jiali Lin, Wen Deng, Jing Liao
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111287
影响因子 ：5.600
引用产品：CL-0620
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Htr2b Promotes M1 Microglia Polarization and Neuroinflammation after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB Signaling(2023/09/25)
作者：Wenhao Chen, Xianlei Gao, Wanliang Yang
期刊：MOLECULAR NEUROBIOLOGY
DOI：10.1007/s12035-023-03656-6
影响因子 ：5.100
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A New Modulator of Neuroinflammation in Diabetic Retinopathy: USP25(2024/03/04)
作者：Qiang Hu, Xue Zhang, Hongsong Peng
期刊：INFLAMMATION
DOI：10.1007/s10753-024-01991-x
影响因子 ：5.100
引用产品：CL-0620
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Iron oxide nanoparticles loaded with paclitaxel inhibits glioblastoma by enhancing autophagy-dependent ferroptosis pathway(2022/03/09)
作者：Hanren Chen, Jian Wen
期刊：European Journal Of Pharmacology
DOI：10.1016/j.ejphar.2022.174860
影响因子 ：5.000
引用产品：CL-0620
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LINC01088 promotes the growth and invasion of glioma cells through regulating small nuclear ribonucleoprotein polypeptide A transcription(2022/04/07)
作者：Tao Peng, Dongliang Chen, Shilan Chen
期刊：Bioengineered.
DOI：10.1080/21655979.2022.2051786
影响因子 ：4.900
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MST1/2 exerts a pivotal role in inducing neuroinflammation and Coxsackievirus-A10 replication by interacting with innate immunity(2024/04/19)
作者：Yajie Hu, Minigmei Zhong, Yaming Lv
期刊：Virology Journal
DOI：10.1186/s12985-024-02355-5
影响因子 ：4.800
引用产品：CL-0620
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Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization(2023/02/06)
作者：Tianrui Zhang, Wulin Liang, Mingqian Zhang
期刊：Pharmaceuticals
影响因子 ：4.600
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Exploring the Therapeutic Effects of Multifunctional N-Salicylic Acid Tryptamine Derivative against Parkinson’s Disease(2023/07/28)
作者：Xuelin Li, Shuzhi Wang, Shan Duan
期刊：ACS Omega
影响因子 ：4.100
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Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats(2021/1/22)
作者：Pengfei Gao, Jiayu Wang, Zhen Su
期刊：PPAR Research
影响因子 ：2.900
引用产品：CL-0620
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Triptolide improves Alzheimers disease by regulating the NF‑κB signaling pathway through the lncRNA NEAT1/microRNA 361‑3p/TRAF2 axis(2023/08/01)
作者：Li Zhou, Xuming Huang, Haiyan Li
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.700
引用产品：CL-0620
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Jagged1-Notch1 Signaling Pathway Induces M1 Microglia to Disrupt the Barrier Function of Retinal Microvascular Endothelial Cells(2024/05/23)
作者：Xiyu Wu, Haoxian Zhu, Junbin Liu
期刊：CURRENT EYE RESEARCH
DOI：10.1080/02713683.2024.2357601
影响因子 ：2.000
引用产品：CL-0620
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Microglia increase CEMIP expression and promote brain metastasis in breast cancer through the JAK2/STAT3 signaling pathway(2023/11/21)
作者：Qi Qin, Chaoying Wang, Yongfu Li
期刊：Oncologie
DOI：10.1515/oncologie-2023-0312
影响因子 ：0.900
引用产品：CL-0620
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