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| 名称 | CAL 27 (人舌鳞癌细胞) (STR鉴定正确) |
| 别称 | Cal-27; CAL 27; Cal 27; CAL27; Cal27; Centre Antoine Lacassagne-27 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | CAL 27细胞是由J·Gioanni于1982年建系，源自一位56岁白人男性的舌头中倍的病变部位；CAL 27细胞角蛋白强阳性。 |
| 年龄（性别） | 男性；56岁 |
| 组织来源 | 舌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 舌鳞癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~20-45 hours |
| 致瘤性 | Yes, solid tumors developed within 6 weeks in nude mice inoculated with 2×10^6 cells subcutaneously. |
| 保藏机构 | ATCC; CRL-2095 DSMZ; ACC-446 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,12 D2S1338 23,24 D3S1358 16 D5S818 11,12 D7S820 10 D8S1179 13,15 D13S317 10,11 D16S539 11,12 D18S51 13 D19S433 14,15.2 D21S11 28,29 FGA 25 PentaD 9,10 PentaE 7 TH01 6,9.3 TPOX 8 vWA 14,17 D6S1043 12 D12S391 18.3,20 D2S441 10,11.3 -
STR鉴定图
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参考文献
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Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway(2022/05/05)
作者：Li Xiao, Xue Li,Peilin Cao
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02376-4
影响因子 ：11.300
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Strong, Tough, and Biocompatible Poly(vinyl alcohol)–Poly(vinylpyrrolidone) Multiscale Network Hydrogels Reinforced by Aramid Nanofibers(2024/04/23)
作者：Dongchao Ji, Zhibo Zhang, Jingxuan Sun
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
引用产品：CL-0265
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Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1(2023/08/08)
作者：Yiming Hou, Wenqian Yu, Gaoyi Wu
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-06024-3
影响因子 ：9.000
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High-Performance Photodynamic Therapy of Tongue Squamous Cell Carcinoma with Multifunctional Nano-Verteporfin(2024/03/13)
作者：Lina Yu, Zidan Xu, Guanxiong Zhu
期刊：International Journal of Nanomedicine
影响因子 ：8.000
引用产品：CL-0265
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Nano-Photosensitizer Directed Targeted Phototherapy Effective Against Oral Cancer in Animal Model(2023/10/31)
作者：Lina Yu, Guanxiong Zhu, Zeyu Zhang
期刊：International Journal of Nanomedicine
影响因子 ：8.000
引用产品：CL-0265
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Tumor Necrosis Factor α–Induced Protein 8–Like Protein 1 Binds to Protein Arginine Methyltransferase 1 To Suppress the Methylation of Signal Transducer and Activator of Transcription 3 and Cell Growth in Oral Squamous Cell Carcinoma(2024/03/02)
作者：Bing Liu, Wen Si, Bo Wei
期刊：AMERICAN JOURNAL OF PATHOLOGY
DOI：10.1016/j.ajpath.2024.02.010
影响因子 ：6.000
引用产品：CL-0265
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BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma(2019/10/7)
作者：Miao Wang, Lu Zhao, Dongdong Tong
期刊：International Immunopharmacology
DOI：10.1016/j.intimp.2019.105921
影响因子 ：5.600
引用产品：CL-0265
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DDX5 Functions as a Tumor Suppressor in Tongue Cancer(2023/12/18)
作者：Qingqing Liu, Yangqing Sun, Min Long
期刊：Cancers
影响因子 ：5.200
引用产品：CL-0265
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Osmanthus-Loaded PVP/PVA Hydrogel Inhibits the Proliferation and Migration of Oral Squamous Cell Carcinoma Cells CAL-27(2022/12/09)
作者：Bin Huang, Chizhou Wu, Yuzhu Hu
期刊：Polymers
影响因子 ：5.000
引用产品：CL-0265
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Identification and in vitro validation of prognostic lncRNA signature in head and neck squamous cell carcinoma(2021/10/15)
作者：Jian Wang, Qinjiang Bian, Jialin Liu
期刊：Bioengineered
DOI：10.1080/21655979.2021.1995577
影响因子 ：4.900
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Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments(2022/10/31)
作者：Chao Ma, Zongming Zhuang, Qisheng Su
期刊：Drug Design Development and Therapy
影响因子 ：4.319
引用产品：CL-0265
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Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2(2022/11/28)
作者：Lan Wu, Sai Ye, Yilin Yao, Chenping Zhang, Wei Liu
期刊：Stem Cells International
影响因子 ：4.300
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SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1(2023/12/28)
作者：Xianzhi Xu, Yiting Mao, Zhaowei Feng
期刊：ONCOLOGY REPORTS
影响因子 ：4.200
引用产品：CL-0265
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Homeobox-D 1 and FTO form a transcriptional–epigenetic feedback loop to promote head and neck cancer proliferation(2023/09/01)
作者：Chunyan Zhang, Linsen Xie, Zhen Lin
期刊：CELL BIOLOGY INTERNATIONAL
影响因子 ：3.900
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Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells(2021/10/07)
作者：Ying Zhou, Shuhong Zhang, Zhonghan Min
期刊：Bmc Cancer
DOI：10.1186/s12885-021-08779-4
影响因子 ：3.800
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Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1(2024/01/22)
作者：Tianzhu Lv, Hongjing Liu, Ling Mao
期刊：BMC CANCER
DOI：10.1186/s12885-024-11855-0
影响因子 ：3.800
引用产品：CL-0265
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Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro(2023/02/17)
作者：Guoqiang Xu, Yiyan Yang, Junting Yang
期刊：BMC CANCER
DOI：10.1186/s12885-023-10600-3
影响因子 ：3.800
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USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination(2024/02/20)
作者：Chang Liu, Shijie Zhou, Wei Tang
期刊：ORAL DISEASES
影响因子 ：3.800
引用产品：CL-0265
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Anticancer role of lidocaine in oral squamous cell carcinoma through IGF2BP2-mediated CAV1 stability(2023/12/09)
作者：Zhi Wang, Lina Zhang, Ting Wu
期刊：ORAL DISEASES
影响因子 ：3.800
引用产品：CL-0265
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CLSPN actives Wnt/β-catenin signaling to facilitate glycolysis and cell proliferation in oral squamous cell carcinoma(2024/01/17)
作者：Zeyu Hou, Chenzhou Wu, Jinru Tang
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2024.113935
影响因子 ：3.700
引用产品：CL-0265
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Pan-cancer analysis reveals the pro-oncogenic role of N6-methyladenosine (m6A)-regulated NTMT1 in head and neck squamous cell carcinoma(2023/11/28)
作者：Chunhong Zhao, Min Yu, Yujie Li
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 ：3.600
引用产品：CL-0265
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Inhibin A contributes to the tumorigenesis of oral squamous cell carcinoma by KIAA1429-mediated m6A modification(2024/03/26)
作者：Xiaoqing Chen, Renxiu Fan
期刊：JOURNAL OF ORAL PATHOLOGY & MEDICINE
影响因子 ：3.300
引用产品：CL-0265
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IFIT3 accelerates the progression of head and neck squamous cell carcinoma by targeting PD-L1 to activate PI3K/AKT signaling pathway(2024/01/25)
作者：Peng Liu, Xin Kong, Shijiang Yi
期刊：World Journal of Surgical Oncology
DOI：10.1186/s12957-023-03274-5
影响因子 ：3.200
引用产品：CL-0265
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Isocorydine Exerts Anticancer Activity by Disrupting the Energy Metabolism and Filamentous Actin Structures of Oral Squamous Carcinoma Cells(2024/01/09)
作者：Qiaozhen Zhou, Qianqian Zhang, Lingzi Liao
期刊：CURRENT ISSUES IN MOLECULAR BIOLOGY
影响因子 ：3.100
引用产品：CL-0265
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Engineered red blood cell membrane for sensitive and precise electrochemical detection of salivary exosomes(2021/12/16)
作者：Libang He, Meiying Shao, Jue Xu
期刊：Analytical Methods
影响因子 ：3.100
引用产品：CL-0265
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High expression of serine protease inhibitor kazal type 1 predicts poor prognosis and promotes the progression and invasion of oral tongue squamous cell carcinoma(2024/05/17)
作者：Shuang Wang, Yaping Sun, Dan Shao
期刊：ARCHIVES OF ORAL BIOLOGY
DOI：10.1016/j.archoralbio.2024.106003
影响因子 ：3.000
引用产品：CL-0265
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Knockdown of circGOLPH3 inhibits cell progression and glycolysis by targeting miR-145-5p/lysine demethylase 2A (KDM2A) axis in oral squamous cell carcinoma(2022/10/21)
作者：Tao Cheng, Feifei Huang, Yin Zhang
期刊：HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
影响因子 ：2.900
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Knockdown of circGOLPH3 inhibits cell progression and glycolysis by targeting miR-145-5p/lysine demethylase 2A (KDM2A) axis in oral squamous cell carcinoma(2022/10/21)
作者：Tao Cheng, Feifei Huang, Yin Zhang
期刊：HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
影响因子 ：2.900
引用产品：CL-0265
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High expression of ACTL6A leads to poor prognosis of oral squamous cell carcinoma patients through promoting malignant progression(2024/03/24)
作者：Yi Liu, Yisha Liu, Ying Li
期刊：HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
影响因子 ：2.900
引用产品：CL-0265
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Silencing of circ_OSBPL10 affects the functional behaviors of oral squamous cell carcinoma cells by the miR-299-3p/CDK6 axis(2022/01/31)
作者：Yong Tai, Yi Li, Mingming Zhang
期刊：Archives Of Oral Biology
DOI：10.1016/j.archoralbio.2022.105363
影响因子 ：2.640
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Correlation of DNA methylation of DNMT3A and TET2 with oral squamous cell carcinoma(2024/01/22)
作者：Xueming Li, Zaikun Li, Qingxi Gao
期刊：Discover Oncology
DOI：10.1007/s12672-024-00866-9
影响因子 ：2.200
引用产品：CL-0265
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