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| 名称 | AsPC-1 (人转移胰腺腺癌细胞) (STR鉴定正确) |
| 别称 | AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | AsPC-1细胞来源于人胰腺癌病人腹水中的细胞裸鼠异种移植而产生的癌性腹水细胞；AsPC-1细胞可以表达CEA、人胰腺相关抗原、人胰腺特异性抗原和黏蛋白。 |
| 年龄（性别） | 女性；62岁 |
| 组织来源 | 胰腺；转移灶；腹水腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胰腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~38-48 hours |
| 基因表达情况 | carcinoembryonic antigen (CEA); human pancreas associated antigen; human pancreas specific antigen; mucin |
| 保藏机构 | ATCC; CRL-1682 BCRC; 60494 ECACC; 96020930 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,13 D2S1338 22,23 D3S1358 16 D5S818 12 D7S820 12,13 D8S1179 13,15 D13S317 9,12 D16S539 11 D18S51 18 D19S433 14 D21S11 28,30 FGA 24 PentaD 9,12 PentaE 5,12 TH01 7,9.3 TPOX 8,10 vWA 17 D6S1043 11,20 D12S391 19 D2S441 11,14 -
STR鉴定图
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参考文献
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D3S-001, a KRAS G12C inhibitor with rapid target engagement kinetics, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities(2024/05/08)
作者：Jing Zhang, Sunmin Lim, Mira Yu
期刊：Cancer Discovery
DOI：10.1158/2159-8290.CD-24-0006
影响因子 ：28.200
引用产品：CL-0027
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ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway(2022/04/07)
作者：Ma Zuyi, Li Zhenchong, Wang Shujie
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02310-8
影响因子 ：11.300
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Albumin binding revitalizes NQO1 bioactivatable drugs as novel therapeutics for pancreatic cancer(2022/08/04)
作者：Lei Dou, Huiqin Liu, Kaixin Wang
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2022.07.033
影响因子 ：10.800
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Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma(2024/02/26)
作者：Yanqin Tan, Bowen Sun, Xi Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-06551-7
影响因子 ：9.000
引用产品：CL-0027
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Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2(2022/09/20)
作者：Meijie Chen, Xuena Li, Bulin Du
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：5.800
引用产品：CL-0027 CL-0042 CL-0059 CL-0184 CL-0448 CL-0627 CM-0059 CM-0448A
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5′-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis(2023/10/12)
作者：Wenpeng Cao, Zhirui Zeng, Shan Lei
期刊：Biomolecules
影响因子 ：5.500
引用产品：CL-0027
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LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4(2024/03/19)
作者：Zhenchong Li, Zuyi Ma, Shujie Wang
期刊：Biology Direct
DOI：10.1186/s13062-024-00463-4
影响因子 ：5.500
引用产品：CL-0027
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Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ promotes proliferation and mobility of pancreatic cancer through AXIN2(2023/07/24)
作者：Wenpeng Cao, Shisi Dai, Wanyuan Ruan
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：5.300
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COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation(2023/02/26)
作者：Yao Song, Lei Wang, Kaidong Wang
期刊：Cancers
影响因子 ：5.200
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KIF2C Facilitates Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma(2023/02/27)
作者：Xing Huang, Feng Zhao, Quan Wu
期刊：Cancers
影响因子 ：5.200
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Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers(2023/02/28)
作者：Qihong Yang, Tong Qin, Tao An
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.175628
影响因子 ：5.000
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MiR-24-3p Inhibits the Progression of Pancreatic Ductal Adenocarcinoma Through LAMB3 Downregulation(2020/01/21)
作者：Wenjie Huang, Jianyou Gu, Tian Tao
期刊：Frontiers in Oncology
影响因子 ：4.700
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GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma(2022/06/05)
作者：Xiaoyuan Sun, Huijun Chu, Ke Lei
期刊：PANCREATOLOGY
影响因子 ：3.977
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Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis(2023/10/30)
作者：Zemin Zhu, Bo Yi, Zikai Tang
期刊：BMC CANCER
DOI：10.1186/s12885-023-11557-z
影响因子 ：3.800
引用产品：CL-0027
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An endoplasmic reticulum stress-related signature could robustly predict prognosis and closely associate with response to immunotherapy in pancreatic ductal adenocarcinoma(2023/08/31)
作者：Shuguang Liu, Qianying Hu, Zishan Xie
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-023-05312-x
影响因子 ：3.600
引用产品：CL-0027
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Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway(2020/3/10)
作者：Xiangpeng Meng, Jia Ma, Baosheng Wang
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-020-00734-4
影响因子 ：3.400
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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization(2024/04/15)
作者：Xuanzeng Pei, Min Cai, Dawei Jiang
期刊：World Journal of Gastrointestinal Oncology
影响因子 ：3.000
引用产品：CL-0027
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Targeting the EZH2-PPAR Axis Is a Potential Therapeutic Pathway for Pancreatic Cancer(2021/7/22)
作者：Jilong Hu, Zhinan Zheng, Jia Lei
期刊：PPAR Research
影响因子 ：2.900
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Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer(2023/02/12)
作者：Jiaxing Du, Yongsheng Chen, Genglong Liu
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.800
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miR-23a-5p inhibits cell proliferation and invasion in pancreatic ductal adenocarcinoma by suppressing ECM1 expression(2019/5/15)
作者：Wenjie Huang, Yaohuan Huang, Jianyou Gu
期刊：American Journal of Translational Research
DOI：PMID:31217868
影响因子 ：2.200
引用产品：CL-0027
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ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma.(2023/11/22)
作者：Yong Yang , Wei Xie, Xuan Qiao
期刊：HISTOLOGY AND HISTOPATHOLOGY
影响因子 ：2.000
引用产品：CL-0027
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Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells(2020/5/20)
作者：Lei Zhang, Zhenyong Wang, Deshuai Kong
期刊：Bioscience Biotechnology And Biochemistry
DOI：10.1080/09168451.2020.1762479
影响因子 ：1.600
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