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产品概述
| 名称 | CFPAC-1 (人胰腺癌细胞) (STR鉴定正确) |
| 别称 | CFPac-1; CF PAC-1; CF-PAC1; CF-Pac1; CF Pac1; CFPAC1; CFPac1; CFPAC |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | CFPAC-1细胞是胰腺管腺癌细胞系，建自26岁白人男性囊性纤维变性(CF)的肝转移灶。CFPAC-1细胞表达囊性纤维变性跨膜调节因子(CFTR)，CFPAC-1细胞形态为上皮细胞样且顶端微绒毛极化。CFPAC-1细胞表达胰腺管细胞特征性的细胞角蛋白和癌胚抗原，倍增时间为30-32小时。CFPAC-1细胞是亚3倍体的细胞系，36％的细胞的染色体模式数为75。CFPAC-1细胞传代至24代时，可在免疫抑制小鼠中致瘤。 |
| 年龄（性别） | 男性；26岁 |
| 组织来源 | 胰腺管腺癌，肝转移 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胰腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~30-45 hours |
| 致瘤性 | Yes, in nude mice (passage 34) |
| 抗原表达情况 | CA19-9 antigen, 12000 units/mL, epithelial keratins |
| 基因表达情况 | carcinoembryonic antigen (CEA), 9ng/mL; pancreatic oncofetal antigen (POA), 28ng/mL; adenocarcinoma associated antigen (ACAA), 5000ng/mL; CA 19-9 antigen, 12000 units/mL; epithelial keratins |
| 保藏机构 | ATCC; CRL-1918 ECACC; 91112501 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10 D2S1338 18,23 D3S1358 16 D5S818 10,11 D7S820 8,10 D8S1179 11,15 D13S317 12 D16S539 9,11 D18S51 12 D19S433 13,15 D21S11 30,31.2 FGA 21,22 PentaD 11,13 PentaE 10,12 TH01 8 TPOX 8 vWA 17 D6S1043 20 D12S391 17 D2S441 10,14 -
STR鉴定图
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参考文献
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Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma(2024/02/26)
作者：Yanqin Tan, Bowen Sun, Xi Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-06551-7
影响因子 ：9.000
引用产品：CL-0059
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High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment(2023/07/11)
作者：Chenggang Gao, Jiaoshun Chen, Jianwei Bai
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-04302-4
影响因子 ：7.400
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System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma(2022/10/05)
作者：Cheng Yan, Yandie Niu, Feng Li
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-022-03632-z
影响因子 ：7.400
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Construction and comprehensive analysis of a novel prognostic signature associated with pyroptosis molecular subtypes in patients with pancreatic adenocarcinoma(2023/02/03)
作者：Qian Huang, Xingyu Peng, Qingqing Li
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1111494
影响因子 ：7.300
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Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapy(2023/06/27)
作者：Yanlong Shi, Yizhu Wang, Hui Dong
期刊：APOPTOSIS
DOI：10.1007/s10495-023-01868-8
影响因子 ：7.200
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Synthesis and anti-tumor activity of nitrogen-containing derivatives of the natural product diphyllin(2022/08/26)
作者：Yang Li, Qing Lu, Ruoxuan Xiao
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2022.114708
影响因子 ：6.700
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PSMD12 interacts with CDKN3 and facilitates pancreatic cancer progression(2023/04/10)
作者：Jia Ma, Wenyang Zhou, Yifeng Yuan
期刊：Cancer Gene Therapy
DOI：10.1038/s41417-023-00609-y
影响因子 ：6.400
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Anti‑silencing function 1B promotes the progression of pancreatic cancer by activating c‑Myc(2022/11/17)
作者：Min Zhang, Luyang Zhang, Minghe Zhou
期刊：INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子 ：5.884
引用产品：CL-0059
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Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2(2022/09/20)
作者：Meijie Chen, Xuena Li, Bulin Du
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：5.800
引用产品：CL-0027 CL-0042 CL-0059 CL-0184 CL-0448 CL-0627 CM-0059 CM-0448A
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5′-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis(2023/10/12)
作者：Wenpeng Cao, Zhirui Zeng, Shan Lei
期刊：Biomolecules
影响因子 ：5.500
引用产品：CL-0059
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RBM15 Promates the Proliferation, Migration and Invasion of Pancreatic Cancer Cell Lines(2023/02/08)
作者：Hui Dong, Haidong Zhang, Xinyu Mao
期刊：Cancers
影响因子 ：5.200
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COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation(2023/02/26)
作者：Yao Song, Lei Wang, Kaidong Wang
期刊：Cancers
影响因子 ：5.200
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Identifying endoplasmic reticulum stress-related molecular subtypes and prognostic model for predicting the immune landscape and therapy response in pancreatic cancer(2023/10/09)
作者：Biao Zhang, Xu Chen, Zhizhou Wang
期刊：Aging-US
影响因子 ：5.200
引用产品：CL-0059
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GID2 interacts with CDKN3 and regulates pancreatic cancer growth and apoptosis(2023/02/23)
作者：Xin Deng, Jia Ma, Wenyang Zhou
期刊：LABORATORY INVESTIGATION
DOI：10.1016/j.labinv.2023.100122
影响因子 ：5.000
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Identification and characterization of interferon-γ signaling-based personalized heterogeneity and therapeutic strategies in patients with pancreatic cancer(2023/10/24)
作者：Xu Chen, Qihang Yuan, Hewen Guan
期刊：Frontiers in Oncology
影响因子 ：4.700
引用产品：CL-0059
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PANoptosis-related molecular subtype and prognostic model associated with the immune microenvironment and individualized therapy in pancreatic cancer(2023/07/14)
作者：Biao Zhang, Bingqian Huang, Xiaonan Zhang
期刊：Frontiers in Oncology
影响因子 ：4.700
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Involvement of Ataxin-3 (ATXN3) in the malignant progression of pancreatic cancer via deubiquitinating HDAC6(2023/07/07)
作者：Xin Wu, Xin Zhang, Peng Liu
期刊：PANCREATOLOGY
影响因子 ：3.600
引用产品：CL-0059
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A prospective prognostic signature for pancreatic adenocarcinoma based on ubiquitination-related mRNA-lncRNA with experimental validation in vitro and vivo(2023/08/04)
作者：Zhizhou Wang, Qihang Yuan, Xu Chen
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-023-01158-1
影响因子 ：2.900
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Construction and validation of a m6A RNA methylation and ferroptosis-related prognostic model for pancreatic cancer by integrated bioinformatics analysis.(2022/10/01)
作者：Tong Wu, Tianyang Qian, Renjie Lin
期刊：Journal of Gastrointestinal Oncology
影响因子 ：2.587
引用产品：CL-0059
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ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma.(2023/11/22)
作者：Yong Yang , Wei Xie, Xuan Qiao
期刊：HISTOLOGY AND HISTOPATHOLOGY
影响因子 ：2.000
引用产品：CL-0059
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