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产品概述
名称 | BxPC-3 (人原位胰腺腺癌细胞) (STR鉴定正确) |
别称 | BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:3-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | BxPC-3细胞不表达囊肿性纤维化跨膜电导调节子(CFTR),CFTR阳性的细胞株是Capan-1。 |
年龄(性别) | 女性;61岁 |
组织来源 | 胰腺;腺癌 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 胰腺癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~48-60 hours |
致瘤性 | Yes, Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
基因表达情况 | mucin; pancreas cancer specific antigen (pancreas cancer associated antigen); carcinoembryonic antigen (CEA) |
保藏机构 | ATCC; CRL-1687 BCRC; 60283 BCRJ; 0056 DSMZ; ACC-760 ECACC; 93120816 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 13 D2S1338 17,19 D3S1358 14,16 D5S818 11 D7S820 10,13 D8S1179 13 D13S317 11 D16S539 9,11 D18S51 12 D19S433 13,16.2 D21S11 29 FGA 20,21 PentaD 14 PentaE 12,14 TH01 9 TPOX 8 vWA 14,18 D6S1043 12 D12S391 19.3,20 D2S441 12,14 -
STR鉴定图
参考文献
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D3S-001, a KRAS G12C inhibitor with rapid target engagement kinetics, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities(2024/05/08)
作者:Jing Zhang, Sunmin Lim, Mira Yu
期刊:Cancer Discovery
DOI:10.1158/2159-8290.CD-24-0006
影响因子 :28.200
引用产品:CL-0042
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Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment(2022/12/21)
作者:Qian Wang, Zihua Wang, Zhangfu Li
期刊:Nano Today
DOI:10.1016/j.nantod.2022.101733
影响因子 :17.400
引用产品:CL-0042
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ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway(2022/04/07)
作者:Ma Zuyi, Li Zhenchong, Wang Shujie
期刊:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI:10.1186/s13046-022-02310-8
影响因子 :11.300
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Albumin binding revitalizes NQO1 bioactivatable drugs as novel therapeutics for pancreatic cancer(2022/08/04)
作者:Lei Dou, Huiqin Liu, Kaixin Wang
期刊:JOURNAL OF CONTROLLED RELEASE
DOI:10.1016/j.jconrel.2022.07.033
影响因子 :10.800
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Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer(2022/12/10)
作者:Xiaoyan Yang, Jinguo Zhang, Qiaomei Zhou
期刊:JOURNAL OF NANOBIOTECHNOLOGY
DOI:10.1186/s12951-022-01738-6
影响因子 :10.200
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Radionuclide labeled nanocarrier for imaging guided combined radionuclide, sonodynamic, and photothermal therapy of pancreatic tumours(2023/03/30)
作者:Jie An, Xinyi He, Huizhu Ma
期刊:JOURNAL OF COLLOID AND INTERFACE SCIENCE
DOI:10.1016/j.jcis.2023.03.111
影响因子 :9.900
引用产品:CL-0042
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SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis(2021/07/24)
作者:Dianyun Ren, Yan Sun, Dan Zhang
期刊:Cancer Letters
DOI:10.1016/j.canlet.2021.07.035
影响因子 :9.700
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pH-Sensitive Biomimetic Nanosystem Based on Large-Pore Mesoporous Silica Nanoparticles with High Hyaluronidase Loading for Tumor Deep Penetration(2023/08/05)
作者:Xiaojie Song, Chunling Li, Nan Qiu
期刊:ACS Applied Materials & Interfaces
影响因子 :9.500
引用产品:CL-0042
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METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation(2023/03/28)
作者:Chengjie Lin, Ting Li, Yan Wang
期刊:Cell Death & Disease
DOI:10.1038/s41419-023-05715-1
影响因子 :9.000
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HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells(2024/03/16)
作者:Ziyang Luo, Qingfang Zheng, Shazhou Ye
期刊:Cell Death & Disease
DOI:10.1038/s41419-024-06592-y
影响因子 :9.000
引用产品:CL-0042
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GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments(2021/08/30)
作者:Yueqin Feng, Yuguan Jiang, Fengjin Hao
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-021-03050-7
影响因子 :7.400
引用产品:CL-0042
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Molecular mechanisms of pancreatic cancer liver metastasis: the role of PAK2(2024/01/26)
作者:Hao Yang, Zhongyi Li, Shiqi Zhu
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2024.1347683
影响因子 :7.300
引用产品:CL-0042
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Pan-cancer analysis of Krüppel-like factor 3 and its carcinogenesis in pancreatic cancer(2023/08/03)
作者:Jinfeng Zhu, Hong Teng, Xiaojian Zhu
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2023.1167018
影响因子 :7.300
引用产品:CL-0042
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Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapy(2023/06/27)
作者:Yanlong Shi, Yizhu Wang, Hui Dong
期刊:APOPTOSIS
DOI:10.1007/s10495-023-01868-8
影响因子 :7.200
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Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2(2022/09/20)
作者:Meijie Chen, Xuena Li, Bulin Du
期刊:BIOCHEMICAL PHARMACOLOGY
影响因子 :5.800
引用产品:CL-0027 CL-0042 CL-0059 CL-0184 CL-0448 CL-0627 CM-0059 CM-0448A
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5′-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis(2023/10/12)
作者:Wenpeng Cao, Zhirui Zeng, Shan Lei
期刊:Biomolecules
影响因子 :5.500
引用产品:CL-0042
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LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4(2024/03/19)
作者:Zhenchong Li, Zuyi Ma, Shujie Wang
期刊:Biology Direct
DOI:10.1186/s13062-024-00463-4
影响因子 :5.500
引用产品:CL-0042
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RBM15 Promates the Proliferation, Migration and Invasion of Pancreatic Cancer Cell Lines(2023/02/08)
作者:Hui Dong, Haidong Zhang, Xinyu Mao
期刊:Cancers
影响因子 :5.200
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COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation(2023/02/26)
作者:Yao Song, Lei Wang, Kaidong Wang
期刊:Cancers
影响因子 :5.200
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Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research(2022/01/08)
作者:Zhenghai Bai, Fangshi Xu, Xiaodan Feng
期刊:Bioengineered
DOI:10.1080/21655979.2021.2019873
影响因子 :4.900
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Aberrant expression of PELI1 caused by Jagged1 accelerates the malignant phenotype of pancreatic cancer(2023/08/30)
作者:Wenyang Zhou, Yuying Hu, Baosheng Wang
期刊:CELLULAR SIGNALLING
DOI:10.1016/j.cellsig.2023.110877
影响因子 :4.800
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PELI1 overexpression contributes to pancreatic cancer progression through upregulating ubiquitination-mediated INPP5J degradation(2024/04/27)
作者:Wenyang Zhou, Xin Deng, Liling Liu
期刊:CELLULAR SIGNALLING
DOI:10.1016/j.cellsig.2024.111194
影响因子 :4.800
引用产品:CL-0042
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Identification and characterization of interferon-γ signaling-based personalized heterogeneity and therapeutic strategies in patients with pancreatic cancer(2023/10/24)
作者:Xu Chen, Qihang Yuan, Hewen Guan
期刊:Frontiers in Oncology
影响因子 :4.700
引用产品:CL-0042
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Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway(2023/08/19)
作者:Litao Zhang, Shuo Wang, Yimin Li
期刊:FOOD AND CHEMICAL TOXICOLOGY
影响因子 :4.300
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GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma(2022/06/05)
作者:Xiaoyuan Sun, Huijun Chu, Ke Lei
期刊:PANCREATOLOGY
影响因子 :3.977
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Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis(2023/10/30)
作者:Zemin Zhu, Bo Yi, Zikai Tang
期刊:BMC CANCER
DOI:10.1186/s12885-023-11557-z
影响因子 :3.800
引用产品:CL-0042
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IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway(2022/01/17)
作者:X-Y Shi, X-L Zhang, Q-Y Shi
期刊:Clinical & Translational Oncology
DOI:10.1007/s12094-021-02748-w
影响因子 :3.400
引用产品:CL-0042
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Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway(2020/3/10)
作者:Xiangpeng Meng, Jia Ma, Baosheng Wang
期刊:Journal Of Physiology And Biochemistry
DOI:10.1007/s13105-020-00734-4
影响因子 :3.400
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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization(2024/04/15)
作者:Xuanzeng Pei, Min Cai, Dawei Jiang
期刊:World Journal of Gastrointestinal Oncology
影响因子 :3.000
引用产品:CL-0042
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Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer(2023/02/12)
作者:Jiaxing Du, Yongsheng Chen, Genglong Liu
期刊:PATHOLOGY RESEARCH AND PRACTICE
影响因子 :2.800
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GPX3 represses pancreatic cancer cell proliferation, migration and invasion, and improves their chemo‑sensitivity by regulating the JNK/c‑Jun signaling pathway(2024/01/29)
作者:Ye Ma, Lixing Zhang, Xin Gao
期刊:Experimental and Therapeutic Medicine
影响因子 :2.700
引用产品:CL-0042
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Construction and validation of a m6A RNA methylation and ferroptosis-related prognostic model for pancreatic cancer by integrated bioinformatics analysis.(2022/10/01)
作者:Tong Wu, Tianyang Qian, Renjie Lin
期刊:Journal of Gastrointestinal Oncology
影响因子 :2.587
引用产品:CL-0042
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Synthesis of Copper and Cobalt complexes with a Hydrothermal Method and Their Applications in Antibiological Activity(2023/12/01)
作者:Qiongli Luo, Lei Wang, Shuangyan Wu
期刊:ChemistrySelect
影响因子 :2.100
引用产品:CL-0042
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ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma.(2023/11/22)
作者:Yong Yang , Wei Xie, Xuan Qiao
期刊:HISTOLOGY AND HISTOPATHOLOGY
影响因子 :2.000
引用产品:CL-0042
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