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| 名称 | A-498 (人肾癌细胞) (STR鉴定正确) |
| 别称 | A498 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | A-498细胞是由Aaronson·S建立，源自一位52岁患有肾癌的女性病人。 |
| 年龄（性别） | 女性；52岁 |
| 组织来源 | 肾脏 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肾癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~60 hours |
| 致瘤性 | Yes, in nude mice; forms undifferentiated carcinoma; also forms tumors in anti thymocyte serum treated newborn mice. |
| 保藏机构 | ATCC; CRL-7908ATCC; HTB-44 DSMZ; ACC-55 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 26 D3S1358 15 D5S818 11,13 D7S820 10,11 D8S1179 13,15 D13S317 12 D16S539 12 D18S51 17 D19S433 12 D21S11 28,32 FGA 18,20 PentaD 9,14 PentaE 10,14 TH01 6,9.3 TPOX 8,11 vWA 18 D6S1043 11 D12S391 21 D2S441 11,14 -
STR鉴定图
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参考文献
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ZDHHC2-mediated AGK palmitoylation activates AKT/mTOR signaling to reduce sunitinib sensitivity in renal cell carcinoma(2023/04/20)
作者：Yan Sun, Liang Zhu, Pian Liu
期刊：CANCER RESEARCH
DOI：10.1158/0008-5472.CAN-22-3105
影响因子 ：11.500
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Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55(2020/12/01)
作者：Jiafu Feng, Yongcan Guo, Yuanmeng Li
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-020-01744-2
影响因子 ：11.300
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YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway(2022/08/17)
作者：Wei Li, Kun Ye, Xurui Li
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02460-9
影响因子 ：11.300
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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming(2023/02/20)
作者：Zhangnan Liu, Mengzhen Fan, Junqing Hou
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05677-4
影响因子 ：9.000
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Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma(2022/09/30)
作者：Liangmin Fu, Jiahao Bao, Jinhui Li
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2022.1021935
影响因子 ：8.786
引用产品：CL-0254
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The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis(2023/02/02)
作者：Yapeng Wang, Mou Peng, Yawen Zhong
期刊：ONCOGENE
DOI：10.1038/s41388-023-02613-w
影响因子 ：8.000
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Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma(2023/08/26)
作者：Yuwei Zhang, Wei Guo, Yangkun Feng
期刊：Computational and Structural Biotechnology Journal
DOI：10.1016/j.csbj.2023.08.023
影响因子 ：6.000
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RETRACTED ARTICLE: Silencing circular RNA-ZNF652 represses proliferation and EMT process of renal carcinoma cells via raising miR-205(2020/2/19)
作者：Ludong Zhang, Ya Guo
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2020.1725532
影响因子 ：5.800
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Disulfideptosis-associated lncRNAs reveal features of prognostic, immune escape, tumor mutation, and tumor malignant progression in renal clear cell carcinoma(2024/02/08)
作者：Xungang Li, Xinxi Deng, Taobin Liu
期刊：Aging-US
影响因子 ：5.200
引用产品：CL-0254
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Focusing on the Abnormal Events of NPC1, NPC2, and NPC1L1 in Pan-Cancer and Further Constructing LUAD and KICH Prediction Models(2023/12/18)
作者：Keheng Chen, Xin Zhang, Guangyu Sun
期刊：JOURNAL OF PROTEOME RESEARCH
DOI：10.1021/acs.jproteome.3c00655
影响因子 ：4.400
引用产品：CL-0254
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The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study(2021/11/10)
作者：Fangshi Xu, Yibing Guan, Li Xue
期刊：Cancer Medicine
影响因子 ：4.000
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HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma(2021/2/19)
作者：Yuanbo Cui, Chunyan Zhang, Ya Li
期刊：Cell Biology International
影响因子 ：3.900
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Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis(2024/01/20)
作者：Wei Zhou, Ji Huang, Chuansheng Huang
期刊：Journal of Cancer
影响因子 ：3.900
引用产品：CL-0254
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SLC11A1 promotes kidney renal clear cell carcinoma (KIRC) progression by remodeling the tumor microenvironment(2024/05/16)
作者：Ding Wu, Yulin Zhou, Xiuquan Shi
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2024.116975
影响因子 ：3.800
引用产品：CL-0254
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Comprehensive analysis of the HOXA gene family identifes HOXA13as a novel oncogenic gene in kidney renal clear cell carcinoma(2020/05/22)
作者：Yuanbo Cui, Ming Yan, Chunyan Zhang
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-020-03259-x
影响因子 ：3.600
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Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC(2024/03/21)
作者：Haolin Li, Mintian Fei, Yi Zhang
期刊：GENE
DOI：10.1016/j.gene.2024.148403
影响因子 ：3.500
引用产品：CL-0254
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Construction and Validation of a Novel Cuproptosis-Related Seven-lncRNA Signature to Predict the Outcomes, Immunotherapeutic Responses, and Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma(2023/01/25)
作者：Haoxun Zhang, Zikuan Ning, Bowen Wang
期刊：DISEASE MARKERS
影响因子 ：3.464
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Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma(2021/09/20)
作者：Peipei Han, Yifang Wang, Wenqi Luo
期刊：Pathology Research And Practice
影响因子 ：3.309
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Decreased expression of TXNIP is associated with poor prognosis and immune infiltration in kidney renal clear cell carcinoma(2024/01/12)
作者：Wanlu Liu, Zhen Xiao, Mingyou Dong
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0254
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Integration of bulk RNA-seq and single-cell RNA-seq constructs: a cancer-associated fibroblasts-related signature to predict prognosis and therapeutic response in clear cell renal cell carcinoma.(2024/04/15)
作者：Jiating Cui, Xuanzhen Zhou, Shuben Sun
期刊：American Journal of Translational Research
影响因子 ：2.200
引用产品：CL-0254
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Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis(2024/05/11)
作者：Bin Zheng, Xue Jiang, Yaqing Liu
期刊：Discover Oncology
DOI：10.1007/s12672-024-01018-9
影响因子 ：2.200
引用产品：CL-0254
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APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells(2021/3/17)
作者：Hua Xia, Yamin Liu, Lei Xu
期刊：IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
DOI：10.1007/s11626-021-00589-z.
影响因子 ：2.100
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Identification of a combined lncRNA prognostic signature and knockdown of lncRNA MANCR to inhibit progression of clear cell renal cell carcinoma by bioinformatics analysis(2022/09/01)
作者：Sheng Xue, Hanxu Guo, Shibo Wei
期刊：Translational Andrology and Urology
影响因子 ：2.000
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CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p(2024/05/19)
作者：Tingting Guo, Wanjuan Xiong, Chong Liu
期刊：GENESIS
影响因子 ：1.500
引用产品：CL-0254
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