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![786-O [786-0] (人肾透明细胞腺癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0010-1-1.jpg)
![786-O [786-0] (人肾透明细胞腺癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0010-1-2.jpg)
![786-O [786-0] (人肾透明细胞腺癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0010-1-3.jpg)
![786-O [786-0] (人肾透明细胞腺癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0010-1-4.jpg)
![786-O [786-0] (人肾透明细胞腺癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0010-1-5.jpg)
![786-O [786-0] (人肾透明细胞腺癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0010-1-6.jpg)
![786-O [786-0] (人肾透明细胞腺癌细胞) (STR鉴定正确)](/Public/upfile/pic/product/cell-line-new.jpg)
产品概述
| 名称 | 786-O [786-0] (人肾透明细胞腺癌细胞) (STR鉴定正确) |
| 别称 | 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | 786-O [786-0]细胞源自一个原发性透明细胞癌；786-O [786-0]细胞有微绒毛和桥粒，能在软琼脂内生长。786-O [786-0]细胞生成的一个PTH样的多肽与乳癌和肺癌中的肽相似。这个多肽的N端与PTH相似，活性与PTH相似，分子量为6000道尔顿。 |
| 年龄（性别） | 男性；58岁 |
| 组织来源 | 肾；肾细胞腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肾癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~24-45 hours |
| 致瘤性 | Yes, in immunosuppressed hamsters. |
| 保藏机构 | ATCC; CRL-1932 BCRC; 60243 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10 D2S1338 17,18 D3S1358 16 D5S818 9 D7S820 11,12 D8S1179 13 D13S317 8 D16S539 12 D18S51 13,14 D19S433 14,15 D21S11 29,30 FGA 24 PentaD 9,12 PentaE 7,16 TH01 6,9.3 TPOX 8,11 vWA 15,17 D6S1043 11 D12S391 17,18 D2S441 10,11 -
STR鉴定图
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参考文献
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Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55(2020/12/01)
作者：Jiafu Feng, Yongcan Guo, Yuanmeng Li
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-020-01744-2
影响因子 ：11.300
-
YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway(2022/08/17)
作者：Wei Li, Kun Ye, Xurui Li
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02460-9
影响因子 ：11.300
-
Integrative Single-Cell Analysis Reveals Transcriptional and Epigenetic Regulatory Features of Clear Cell Renal Cell Carcinoma(2023/03/02)
作者：Zhenyuan Yu, Yufang Lv, Cheng Su
期刊：CANCER RESEARCH
DOI：10.1158/0008-5472.CAN-22-2224
影响因子 ：11.200
-
The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors(2022/04/02)
作者：Liu Wentao, Zhang Bin, Zhang Dan
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-04760-6
影响因子 ：9.000
引用产品：CL-0005 CL-0010 CL-0021 PB180120 PM150110 PM150210 PM150410
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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming(2023/02/20)
作者：Zhangnan Liu, Mengzhen Fan, Junqing Hou
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05677-4
影响因子 ：9.000
-
Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma(2022/09/30)
作者：Liangmin Fu, Jiahao Bao, Jinhui Li
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2022.1021935
影响因子 ：8.786
引用产品：CL-0010
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Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination(2023/11/01)
作者：Lin Wang, Hui Li, Aixue Huang
期刊：ONCOGENE
DOI：10.1038/s41388-023-02879-0
影响因子 ：8.000
引用产品：CL-0010
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The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis(2023/02/02)
作者：Yapeng Wang, Mou Peng, Yawen Zhong
期刊：ONCOGENE
DOI：10.1038/s41388-023-02613-w
影响因子 ：8.000
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Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells(2024/03/30)
作者：Ziyao Li, Ye Tian, Huafeng Zong
期刊：APOPTOSIS
DOI：10.1007/s10495-024-01953-6
影响因子 ：7.200
引用产品：CL-0010
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Vaporization phosphorization-mediated synthesis of phosphorus-doped TiO2 nanocomposites for combined photodynamic and photothermal therapy of renal cell carcinoma(2024/04/09)
作者：Zhuo Song, Chen Guan, Tianyang Li
期刊：Journal of Materials Chemistry B
影响因子 ：7.000
引用产品：CL-0010
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Selective expansion of renal cancer stem cells using microfluidic single-cell culture arrays for anticancer drug testing(2024/02/01)
作者：Xiaogang Wang, Tao He, Zihe Chen
期刊：LAB ON A CHIP
影响因子 ：6.100
引用产品：CL-0010
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Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma(2023/08/26)
作者：Yuwei Zhang, Wei Guo, Yangkun Feng
期刊：Computational and Structural Biotechnology Journal
DOI：10.1016/j.csbj.2023.08.023
影响因子 ：6.000
-
Identification of molecular subtypes and diagnostic model in clear cell renal cell carcinoma based on collagen-related genes may predict the response of immunotherapy(2024/02/05)
作者：Yulong Hong, Zhengtong Lv, Zhuo Xing
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1325447
影响因子 ：5.600
引用产品：CL-0010
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Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.(2022/09/21)
作者：Longfei Yang, Yuwei Zhang, Yang Wang
期刊：Frontiers in Pharmacology
影响因子 ：5.600
引用产品：CL-0002 CL-0010 CL-0052 CL-0075 CL-0109 CL-0185 CL-0222 CL-0227 CM-H019 PM150110 PM150210 PM150910
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Cytotoxic and Antibacterial Meroterpenoids Isolated from the Marine-Derived Fungus Talaromyces sp. M27416(2024/04/20)
作者：Lingzhi Tang, Jinmei Xia, Zhongwei Chen
期刊：Marine Drugs
影响因子 ：5.400
引用产品：CL-0010
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The mechanism of long-chain acyl-CoA synthetase 3 in inhibiting cell proliferation, migration, and invasion in clear cell renal cell carcinoma(2023/03/15)
作者：Lin Zhang, Bo Wu, Dongwen Wang
期刊：American Journal of Cancer Research
DOI：PMID:37034217
影响因子 ：5.300
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Disulfideptosis-associated lncRNAs reveal features of prognostic, immune escape, tumor mutation, and tumor malignant progression in renal clear cell carcinoma(2024/02/08)
作者：Xungang Li, Xinxi Deng, Taobin Liu
期刊：Aging-US
影响因子 ：5.200
引用产品：CL-0010
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Hypoxia-induced microRNA-155 overexpression in extracellular vesicles promotes renal cell carcinoma progression by targeting FOXO3(2021/03/19)
作者：Liwei Meng, Zhaoquan Xing, Zhaoxin Guo
期刊：Aging-US
影响因子 ：5.200
引用产品：CL-0010
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LncRNA-encoded Micropeptide ACLY-BP drives lipid deposition and cell proliferation in Clear Cell Renal Cell Carcinoma via maintenance of ACLY acetylation(2023/07/06)
作者：Shenghua Zhang, Zheng Zhang, Xiaolong Liu
期刊：MOLECULAR CANCER RESEARCH
DOI：10.1158/1541-7786.MCR-22-0781
影响因子 ：5.200
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EMILIN2 is associated with prognosis and immunotherapy in clear cell renal cell carcinoma(2022/12/05)
作者：Guangjian Zhao, Jianpei Zheng, Kai Tang
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2022.1058207
影响因子 ：4.772
引用产品：CL-0010
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Tumor-associated M2 macrophages in the immune microenvironment influence the progression of renal clear cell carcinoma by regulating M2 macrophage-associated genes(2023/06/08)
作者：Xiaoxu Zhang, Yang Sun, Yushuo Ma
期刊：Frontiers in Oncology
影响因子 ：4.700
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Expression of gasdermin D in clear cell renal cell carcinoma and its effect on its biological function(2023/07/06)
作者：Zhang Jichi, Wang Yujie, Ma Jun, Aimudula Ainiwaer
期刊：Frontiers in Oncology
影响因子 ：4.700
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Low ACADM expression predicts poor prognosis and suppressive tumor microenvironment in clear cell renal cell carcinoma(2024/04/25)
作者：Libin Zhou, Min Yin, Fei Guo
期刊：Scientific Reports
DOI：10.1038/s41598-024-59746-5
影响因子 ：4.600
引用产品：CL-0010
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A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance(2023/04/08)
作者：Longfei Yang, Yuwei Zhang, Yifan Tang
期刊：Scientific Reports
DOI：10.1038/s41598-023-27975-9
影响因子 ：4.600
引用产品：CL-0002 CL-0010 CL-0052 CL-0075 CL-0109 CL-0185 CL-0222 CL-0227 CM-H019 PM150110 PM150210 PM150910
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Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma(2024/05/25)
作者：Songsong Wang, Yan Li, Yilong Lin
期刊：Scientific Reports
DOI：10.1038/s41598-024-62738-0
影响因子 ：4.600
引用产品：CL-0010
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AKG induces cell apoptosis by inducing reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing PI3K/AKT/mTOR-mediated autophagy in renal cell carcinoma(2022/09/16)
作者：Fan Wu, Xuexia Xie, Guoliang Li
期刊：ENVIRONMENTAL TOXICOLOGY
影响因子 ：4.500
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Crosstalk of disulfidptosis-related subtypes identifying a prognostic signature to improve prognosis and immunotherapy responses of clear cell renal cell carcinoma patients(2024/04/26)
作者：Lei Ren, Jinwen Liu, Qingyuan Lin
期刊：BMC GENOMICS
DOI：10.1186/s12864-024-10307-0
影响因子 ：4.400
引用产品：CL-0010
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ROCK2-RNA interaction map reveals multiple biological mechanisms underlying tumor progression in renal cell carcinoma(2023/07/07)
作者：Zhengdong Hong, Xuexin Chen, Lei Wang
期刊：Human Cell
DOI：10.1007/s13577-023-00947-x
影响因子 ：4.300
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GBP2 promotes clear cell renal cell carcinoma progression through immune infiltration and regulation of PD‑L1 expression via STAT1 signaling(2023/01/20)
作者：Shujiang Ye, Siyu Li, Lei Qin
期刊：ONCOLOGY REPORTS
影响因子 ：4.200
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Design, synthesis and biological evaluation of rhein–piperazine–furanone hybrids as potential anticancer agents(2024/02/13)
作者：Yu He, Sisi Zhang, Mengxue Wei
期刊：RSC Medicinal Chemistry
影响因子 ：4.100
引用产品：CL-0010
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Total Flavone Content of Cydonia oblonga Miller Inhibits Proliferation and Migration of Renal Carcinoma Cells by Inhibiting the S1PR2/FAK Pathway(2023/03/30)
作者：Muhadaisi Nuer, Nawaz Khan, Bentuo Zhang
期刊：JOURNAL OF FOOD BIOCHEMISTRY
影响因子 ：4.000
-
Dysregulated ANLN reveals immune cell landscape and promotes carcinogenesis by regulating the PI3K/Akt/mTOR pathway in clear cell renal cell carcinoma(2023/12/09)
作者：Mingzhu Gao, Zhouting Tuo, Zhiwei Jiang
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e23522
影响因子 ：4.000
引用产品：CL-0010
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The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study(2021/11/10)
作者：Fangshi Xu, Yibing Guan, Li Xue
期刊：Cancer Medicine
影响因子 ：4.000
-
Tropomyosin-1 Functions as a Tumor Suppressor with Respect to Cell Proliferation, Angiogenesis and Metastasis in Renal Cell Carcinoma(2019/05/21)
作者：Jin Wang, Chao Tang, Chao Yang
期刊：Journal of Cancer
影响因子 ：3.900
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HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma(2021/2/19)
作者：Yuanbo Cui, Chunyan Zhang, Ya Li
期刊：Cell Biology International
影响因子 ：3.900
-
Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis(2024/01/20)
作者：Wei Zhou, Ji Huang, Chuansheng Huang
期刊：Journal of Cancer
影响因子 ：3.900
引用产品：CL-0010
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SLC11A1 promotes kidney renal clear cell carcinoma (KIRC) progression by remodeling the tumor microenvironment(2024/05/16)
作者：Ding Wu, Yulin Zhou, Xiuquan Shi
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2024.116975
影响因子 ：3.800
引用产品：CL-0010
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Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma(2022/08/09)
作者：Xiao Liu, Meng Jiang, Chenggang Pang
期刊：BMC CANCER
DOI：10.1186/s12885-022-09965-8
影响因子 ：3.800
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Comprehensive analysis of the HOXA gene family identifes HOXA13as a novel oncogenic gene in kidney renal clear cell carcinoma(2020/05/22)
作者：Yuanbo Cui, Ming Yan, Chunyan Zhang
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-020-03259-x
影响因子 ：3.600
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LINC00645 inhibits renal cell carcinoma progression by interacting with HNRNPA2B1 to regulate the ROCK1 mRNA stability(2024/02/01)
作者：Hao Li, Xu Han, Liang Song
期刊：GENE
DOI：10.1016/j.gene.2024.148232
影响因子 ：3.500
引用产品：CL-0010
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Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC(2024/03/21)
作者：Haolin Li, Mintian Fei, Yi Zhang
期刊：GENE
DOI：10.1016/j.gene.2024.148403
影响因子 ：3.500
引用产品：CL-0010
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P4HA3 promotes clear cell renal cell carcinoma progression via the PI3K/AKT/GSK3β pathway(2023/01/02)
作者：Zhechuan Zhang, Yuanfeng Zhang, Ronggui Zhang
期刊：MEDICAL ONCOLOGY
DOI：10.1007/s12032-022-01926-2
影响因子 ：3.400
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Tropomyosin-1 promotes cancer cell apoptosis via the p53-mediated mitochondrial pathway in renal cell carcinoma(2018/3/7)
作者：Chao Tang, Jin Wang, Qi Wei
期刊：Oncology Letters
影响因子 ：2.900
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Downregulation of NEBL promotes migration and invasion of clear cell renal cell carcinoma by inducing epithelial-mesenchymal transition(2023/12/29)
作者：Ran Zhao, Ziyuan Liang, Jiemei Chu
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.800
引用产品：CL-0010
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RUNX1 predicts poor prognosis and correlates with tumor progression in clear cell renal carcinoma(2023/10/12)
作者：Jing Ma, Shaofei He, Mingyang Li
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.800
引用产品：CL-0010
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Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis(2021/1/20)
作者：Fanchang Zeng, Liumei Luo, Mi Song
期刊：Journal Of Receptors And Signal Transduction
DOI：10.1080/10799893.2020.1870494
影响因子 ：2.800
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TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression(2023/10/30)
作者：Lingling Xie, Yu Fang, Jianping Chen
期刊：PeerJ
影响因子 ：2.700
引用产品：CL-0010
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Comprehensive Pan-Cancer Analysis of Connexin 43 as a Potential Biomarker and Therapeutic Target in Human Kidney Renal Clear Cell Carcinoma (KIRC)(2024/05/08)
作者：Huzi Xu, Xiuru Wang, Fan Zhu
期刊：Medicina-Lithuania
影响因子 ：2.600
引用产品：CL-0010
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Integration of bulk RNA-seq and single-cell RNA-seq constructs: a cancer-associated fibroblasts-related signature to predict prognosis and therapeutic response in clear cell renal cell carcinoma.(2024/04/15)
作者：Jiating Cui, Xuanzhen Zhou, Shuben Sun
期刊：American Journal of Translational Research
影响因子 ：2.200
引用产品：CL-0010
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High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer(2023/02/23)
作者：Haiqing Wang, Sen Chen, Wenhui Kang
期刊：Discover Oncology
DOI：10.1007/s12672-023-00634-1
影响因子 ：2.200
引用产品：CL-0010
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Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis(2024/05/11)
作者：Bin Zheng, Xue Jiang, Yaqing Liu
期刊：Discover Oncology
DOI：10.1007/s12672-024-01018-9
影响因子 ：2.200
引用产品：CL-0010
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APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells(2021/3/17)
作者：Hua Xia, Yamin Liu, Lei Xu
期刊：IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
DOI：10.1007/s11626-021-00589-z.
影响因子 ：2.100
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Identification of a combined lncRNA prognostic signature and knockdown of lncRNA MANCR to inhibit progression of clear cell renal cell carcinoma by bioinformatics analysis(2022/09/01)
作者：Sheng Xue, Hanxu Guo, Shibo Wei
期刊：Translational Andrology and Urology
影响因子 ：2.000
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Circ_0000069 contributes to the growth, metastasis and glutamine metabolism in renal cell carcinoma (RCC) via regulating miR-125a-5p-dependent SLC1A5 expression(2022/11/30)
作者：Liqing Yang, Lin Wang, Jitao Wu, Yongqiang Wang
期刊：TRANSPLANT IMMUNOLOGY
DOI：10.1016/j.trim.2022.101764
影响因子 ：1.500
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CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p(2024/05/19)
作者：Tingting Guo, Wanjuan Xiong, Chong Liu
期刊：GENESIS
影响因子 ：1.500
引用产品：CL-0010
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