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产品概述
| 名称 | PC-9 (人肺癌细胞) (STR鉴定正确) |
| 别称 | PC9; PC-9/S1; PC-9S1 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞，少量悬浮 |
| 细胞形态 | 圆形和纺锤形混合 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:5 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | 源自人肺腺癌，该肺组织仍处于分化状态。PC-9（以前称为PC-14）。PC-14 最初于1989 年作为源自人肺腺癌（未分化型）的细胞系存放在RIKEN生物资源中心。该生物资源中心通过短串联重复序列 (STR) DNA 分析发现该细胞系与 PC-9 相同，PC-9 是源自人肺腺癌（分化型）的细胞系。此错误识别发生在细胞系存放在 RIKEN 生物资源中心之前。细胞系的名称更改为 PC-9，以反映这一发现。 |
| 年龄（性别） | 男性；45岁 |
| 组织来源 | 肺 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~48 hours |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11 D2S1338 19,20 D3S1358 16 D5S818 11 D7S820 10,11 D8S1179 11,15 D13S317 8 D16S539 9 D18S51 15 D19S433 13,15.2 D21S11 29,30 FGA 23,25 PentaD 9,13 PentaE 11,15 TH01 7 TPOX 11 vWA 17 D6S1043 13,19 D12S391 18 D2S441 11 -
STR鉴定图
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参考文献
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circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP/IL-6 axis(2024/03/08)
作者：Yan Zhao, Yunlong Jia, Jiali Wang
期刊：Molecular Cancer
DOI：10.1186/s12943-024-01957-5
影响因子 ：37.300
引用产品：CL-0668
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Original research: Hsa-LINC02418/mmu-4930573I07Rik regulated by METTL3 dictates anti-PD-L1 immunotherapeutic efficacy via enhancement of Trim21-mediated PD-L1 ubiquitination(2023/12/01)
作者：Zhijia Sun, Haixing Mai, Chunyuan Xue
期刊：Journal for ImmunoTherapy of Cancer
影响因子 ：10.900
引用产品：CL-0668
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ZBTB16 inhibits DNA replication and induces cell cycle arrest by targeting WDHD1 transcription in lung adenocarcinoma(2024/04/23)
作者：Kai Wang, Deyu Guo, Tao Yan
期刊：ONCOGENE
DOI：10.1038/s41388-024-03041-0
影响因子 ：8.000
引用产品：CL-0668
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LncRNA CCAT2 promotes tumorigenesis by over-expressed Pokemon in non-small cell lung cancer(2017/01/12)
作者：Zhihong Zhao, Ju Wang, Shengfa Wang
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2016.12.122
影响因子 ：7.500
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Prediction of prognosis, immunogenicity and efficacy of immunotherapy based on glutamine metabolism in lung adenocarcinoma(2022/08/11)
作者：Jichang Liu, Hongchang Shen, Wenchao Gu
期刊：Frontiers in Immunology
影响因子 ：7.300
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Tumor-suppressive E3 ubiquitin ligase CHIP inhibits the PBK/ERK axis to repress stem cell properties and radioresistance in non-small cell lung cancer(2022/11/27)
作者：Tan, Bo, Zhang, Jingwei, Wang, Wen, Ma, Haibo, Yang, Yuanyuan
期刊：APOPTOSIS
DOI：10.1007/s10495-022-01789-y
影响因子 ：7.200
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NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence(2024/03/12)
作者：Shuman Zhen, Yunlong Jia, Yan Zhao
期刊：Cell Death Discovery
DOI：10.1038/s41420-024-01892-w
影响因子 ：7.000
引用产品：CL-0668
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Disulfiram enhances cisplatin cytotoxicity by forming a novel platinum chelate Pt(DDTC)3+(2023/03/11)
作者：Xuexia Yuan, Youfa Duan, Chunxiang Luo
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：5.800
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Identification of key immune cells infiltrated in lung adenocarcinoma microenvironment and their related long noncoding RNA(2024/02/15)
作者：Kai Wang, Tao Yan, Deyu Guo
期刊：iScience
DOI：10.1016/j.isci.2024.109220
影响因子 ：5.800
引用产品：CL-0668
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Identifying the critical oncogenic mechanism of LDHA based on a prognostic model of T-cell synthetic drivers(2023/11/23)
作者：Guanghui Wang, Haotian Zheng, Yunzhi Xiang
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111265
影响因子 ：5.600
引用产品：CL-0668
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Onvansertib inhibits the proliferation and improves the cisplatin-resistance of lung adenocarcinoma via β-catenin/c-Myc signaling pathway(2023/02/15)
作者：Rong Wang, Yihan Hou, Guojun Geng
期刊：American Journal of Cancer Research
DOI：PMID:36895968
影响因子 ：5.300
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MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2(2024/04/23)
作者：Hui Yu, Xianrong Xu, Lirong Zhu
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：5.300
引用产品：CL-0668
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Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner(2021/02/09)
作者：Peng Xiao, Yukang Liu, Wei Han
期刊：Molecular Cancer Research
DOI：10.1158/1541-7786.MCR-20-0541
影响因子 ：5.200
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Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma(2023/11/10)
作者：Yong Liu, Zhaofei Pang, Yadong Wang
期刊：CHEMICO-BIOLOGICAL INTERACTIONS
影响因子 ：5.100
引用产品：CL-0668
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Cyclin D1 mediated by the nuclear translocation of nuclear factor kappa B exerts an oncogenic role in lung cancer(2022/03/04)
作者：Xin Wang, Xiaoping Liu, Yanxia Yang
期刊：Bioengineered
DOI：10.1080/21655979.2022.2043099
影响因子 ：4.900
引用产品：CL-0668
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Comprehensive analysis of cuproptosis and copper homeostasis genotyping and related immune land scape in lung adenocarcinoma(2023/10/02)
作者：Dayuan Luo, Xiang Wang, Wei Feng
期刊：Scientific Reports
DOI：10.1038/s41598-023-43795-3
影响因子 ：4.600
引用产品：CL-0668
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Macrophage-Related Gene Signatures for Predicting Prognosis and Immunotherapy of Lung Adenocarcinoma by Machine Learning and Bioinformatics(2024/02/06)
作者：Yunzhi Xiang, Guanghui Wang, Baoliang Liu
期刊：Journal of Inflammation Research
影响因子 ：4.500
引用产品：CL-0668
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Design, synthesis and biological evaluation of rhein–piperazine–furanone hybrids as potential anticancer agents(2024/02/13)
作者：Yu He, Sisi Zhang, Mengxue Wei
期刊：RSC Medicinal Chemistry
影响因子 ：4.100
引用产品：CL-0668
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MCF2L-AS1/miR-874-3p/STAT3 feedback loop contributes to lung adenocarcinoma cell growth and cisplatin resistance(2023/10/29)
作者：Min Xu, Jing Zheng, Jun Wang
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e21342
影响因子 ：4.000
引用产品：CL-0668
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SLC7A5 is a lung adenocarcinoma-specific prognostic biomarker and participates in forming immunosuppressive tumor microenvironment(2022/10/02)
作者：Yong Liu, Guoyuan Ma, Jichang Liu
期刊：Heliyon
DOI：10.1016/j.heliyon.2022.e10866
影响因子 ：4.000
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Different lactate metabolism subtypes reveal heterogeneity in clinical outcomes and immunotherapy in lung adenocarcinoma patients(2024/05/06)
作者：Jing Zhang, Yun Bao, Yang Li
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e30781
影响因子 ：4.000
引用产品：CL-0668
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Development and validation of an endoplasmic reticulum stress long non-coding RNA signature for the prognosis and immune landscape prediction of patients with lung adenocarcinoma(2023/02/20)
作者：Jie Zeng, Zhenyu Wu, Meijuan Luo
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1024444
影响因子 ：3.700
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FOXP family DNA methylation correlates with immune infiltration and prognostic value in NSCLC.(2022/09/09)
作者：Dongmei Hu, Wendi Zhang, ZhuangE Shi
期刊：Frontiers in Genetics
影响因子 ：3.700
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CircDUS2L (circ_0039908) promotes lung adenocarcinoma progression by upregulating PGAM1 by acting as a miR-590-5p molecular sponge(2023/07/01)
作者：Qing Tian, Ying Guo, Jinfeng Liu
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 ：3.600
引用产品：CL-0005 CL-0016 CL-0668 PB180120 PM150110 PM150210 PM150910
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Multi-omics analysis of expression profile and prognostic values of connexin family in LUAD(2023/07/17)
作者：Peng Jiang, Xingfa Huo, Bowen Dong
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-023-05075-5
影响因子 ：3.600
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STARD12/14 are diagnostic and prognostic biomarkers of lung adenocarcinoma associated with epigenetic regulation, immune infiltration and ferroptosis(2023/09/11)
作者：Wendi Zhang, Dongmei Hu, Zhuang-E Shi
期刊：International Journal of Medical Sciences
影响因子 ：3.600
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Silencing of circ_0088036 inhibits growth and invasion of lung adenocarcinoma through miR-203/SP1 axis(2024/03/27)
作者：Xiuhua Liu, Yan Feng, Linna Wang
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 ：3.600
引用产品：CL-0668
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Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis(2021/8/13)
作者：Baodan Yu, Lixia Zheng, Huiqin Tang
期刊：Molecular Medicine Reports
影响因子 ：3.400
引用产品：CL-0668
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KIAA1429-mediated RXFP1 attenuates non-small cell lung cancer tumorigenesis via N6-methyladenosine modification(2024/02/07)
作者：Zhixiang Zhang, Jipeng Guo, Chongwen Gong
期刊：Cancer Biomarkers
影响因子 ：3.100
引用产品：CL-0668
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Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression(2023/11/23)
作者：Qi Li, Min Zhao, Dandan Hu
期刊：Cancer Biomarkers
影响因子 ：3.100
引用产品：CL-0668
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ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression(2024/01/11)
作者：Letian Chen, Dongdong Zhang, Yujuan Chen
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0668
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Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma(2023/02/24)
作者：Rui Chen, Zhiping Wang, Tianzhu Lu
期刊：Thoracic Cancer
影响因子 ：2.900
引用产品：CL-0016 CL-0161 CL-0165 CL-0166 CL-0298 CL-0668 CM-0161
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Calponin 3 suppresses proliferation, migration and invasion of non‑small cell lung cancer cells(2021/7/1)
作者：Chenglin Yang, Shiping Zhu, Weifeng Feng
期刊：Oncology Letters
影响因子 ：2.900
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Oxymatrine induces apoptosis in non-small cell lung cancer cells by downregulating TRIM46(2024/05/23)
作者：Yi Zhong, Biaobiao Luo, Min Hong
期刊：TOXICON
DOI：10.1016/j.toxicon.2024.107773
影响因子 ：2.800
引用产品：CL-0668
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The m6 RNA methylation regulator KIAA1429 is associated with autophagy‐mediated drug resistance in lung cancer(2024/03/15)
作者：Bo Ma, Lei Xiu, Lili Ding
期刊：FASEB BioAdvances
影响因子 ：2.700
引用产品：CL-0668
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Identification of a novel intermittent hypoxia-related prognostic lncRNA signature and the ceRNA of lncRNA GSEC/miR-873-3p/EGLN3 regulatory axis in lung adenocarcinoma(2023/10/10)
作者：Peijun Liu, Long Zhou, Hao Chen
期刊：PeerJ
影响因子 ：2.700
引用产品：CL-0668
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Integrin β4 Regulates Cell Migration of Lung Adenocarcinoma Through FAK Signaling(2024/02/08)
作者：Shusen Zhang, Chengyu Liu, Dengxiang Liu
期刊：MOLECULAR BIOTECHNOLOGY
DOI：10.1007/s12033-024-01061-5
影响因子 ：2.600
引用产品：CL-0668
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UTMD-mediated delivery of miR-21-5p inhibitor suppresses the development of lung cancer(2021/12/23)
作者：Xiaoyu Zhou, Haitao Liu, Yingying Pang
期刊：Tissue & Cell
DOI：10.1016/j.tice.2021.101719
影响因子 ：2.600
引用产品：CL-0668
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Knockdown of circLRWD1 weakens DDP resistance via reduction of SIRT5 expression through releasing miR-507 in non-small cell lung cancer(2022/08/10)
作者：Zhongbiao Deng, Qimin Tu, Guoliang Hu
期刊：ANTI-CANCER DRUGS
DOI：10.1097/CAD.0000000000001364
影响因子 ：2.389
引用产品：CL-0668
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NFATc2 promotes lactate and M2 macrophage polarization through USP17 in lung adenocarcinoma(2024/02/23)
作者：Liang Wang, Yuanyuan Ma, Shanyuan Zhang
期刊：ANTI-CANCER DRUGS
DOI：10.1097/CAD.0000000000001582
影响因子 ：2.300
引用产品：CL-0668
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Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A Pathway(2023/10/11)
作者：Chengbo Ren, Ling Cui, Ruibiao Li
期刊：HORMONE AND METABOLIC RESEARCH
影响因子 ：2.200
引用产品：CL-0668
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High level of LncRNA MAPKAPK5-AS1 predicts poor prognosis and contributes to the malignant proliferation and EMT of non-small cell lung cancer via sponging miR-490-3p from HMGB2(2022/11/29)
作者：Miao, Jidong, Gao, Yang, Guan, Wenqiang, Yu, Xiaolin, Wang, Yong, Jiang, Ping, Yang, Lili, Xu, Lun, You, Wei
期刊：Genes & Genomics
DOI：10.1007/s13258-022-01339-5
影响因子 ：2.100
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Synergistic anti-tumor effects of lenalidomide and gefitinib by upregulating ADRB2 and inactivating the mTOR/PI3K/AKT signaling pathway in lung adenocarcinoma(2024/02/29)
作者：Shuangshuang Zhou, Meiyi Deng, Xuyu Bian
期刊：CELLULAR AND MOLECULAR BIOLOGY
影响因子 ：1.600
引用产品：CL-0668
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