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| 名称 | HOS (人骨肉瘤细胞)(STR鉴定正确） |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞、上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | HOS细胞是从一名13岁的白人女性的骨肉瘤组织中分离建立的；HOS细胞表现为扁平形态、低饱和密度、软琼脂中的低克隆形成率和对化合物及病毒感染的敏感性。 |
| 年龄（性别） | 女性；13岁 |
| 组织来源 | 骨；骨肉瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肉瘤细胞 |
| 生物安全等级 | BSL-1 |
| 保藏机构 | ATCC; CRL-1543 ECACC; 87070202 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 24,25 D3S1358 15 D5S818 13 D7S820 11,12 D8S1179 14 D13S317 12 D16S539 10,13 D18S51 14 D19S433 13 D21S11 31.2,32.2 FGA 24 PentaD 9,10 PentaE 7,12 TH01 6 TPOX 8,11 vWA 18 D6S1043 18 D12S391 20 D2S441 10 -
STR鉴定图
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参考文献
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A novel photothermally controlled multifunctional scaffold for clinical treatment of osteosarcoma and tissue regeneration(2020/06/01)
作者：Liang Ma, Xiaobo Feng, Hang Liang
期刊：Materials Today
DOI：10.1016/j.mattod.2019.12.005
影响因子 ：24.200
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression(2021/08/26)
作者：Lei Ding, Taiyuan Liu, Yuan Qu
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.08.022
影响因子 ：8.800
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Comprehensive analysis of a glycolysis and cholesterol synthesis-related genes signature for predicting prognosis and immune landscape in osteosarcoma(2022/12/23)
作者：Fangxing Xu, Jinglong Yan, Zhibin Peng
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2022.1096009
影响因子 ：8.786
引用产品：CL-0360
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Dipsacus Asperoides-Derived Exosomes-Like Nanoparticles Inhibit the Progression of Osteosarcoma via Activating P38/JNK Signaling Pathway(2024/02/01)
作者：Jiaxu Lu, Jiaxian Chen, Junhong Ye
期刊：International Journal of Nanomedicine
影响因子 ：8.000
引用产品：CL-0360
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Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression(2024/02/15)
作者：Zhuo Chen, Fengfeng Wu, Jing Li
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.155459
影响因子 ：7.900
引用产品：CL-0360
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Ziyuglycoside II, a triterpene glycoside compound in Sanguisorbae officinalis L. extract, suppresses metastasis in osteosarcoma via CBX4-mediated Wnt/β-catenin signal pathway(2024/05/09)
作者：Zhewen Deng, Jitong Yuan, Beiting Ma
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.155716
影响因子 ：7.900
引用产品：CL-0360
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Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction(2023/12/15)
作者：Junchao Zhu, Jinghong Yuan, Shahrzad Arya
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1265098
影响因子 ：7.300
引用产品：CL-0360
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Multi-omics analysis reveals cuproptosis and mitochondria-based signature for assessing prognosis and immune landscape in osteosarcoma(2024/01/05)
作者：Chenguang Jia, Mei Liu, Liming Yao
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1280945
影响因子 ：7.300
引用产品：CL-0360
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A novel molecular signature for predicting prognosis and immunotherapy response in osteosarcoma based on tumor-infiltrating cell marker genes(2023/04/06)
作者：Haijun Tang, Shangyu Liu, Xiaoting Luo
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1150588
影响因子 ：7.300
引用产品：CL-0360
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Dissecting the effect of sphingolipid metabolism gene in progression and microenvironment of osteosarcoma to develop a prognostic signature(2022/10/14)
作者：Yujian Zhong, Yubiao Zhang, Sixing Wei
期刊：Frontiers in Endocrinology
DOI：10.3389/fendo.2022.1030655
影响因子 ：6.055
引用产品：CL-0360
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CKB affects human osteosarcoma progression by regulating the p53 pathway(2022/10/15)
作者：Fengxin Zhou, Xinli Dou, Chenguang Li
期刊：American Journal of Cancer Research
DOI：PMID:36381321
影响因子 ：5.942
引用产品：CL-0360
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy(2019/08/07)
作者：Hongliang Ying, Boda Ying, Jinrui Zhang
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1648280
影响因子 ：5.800
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Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9(2021/07/14)
作者：Weihang Li, Ziyi Ding, Dong Wang
期刊：Cancer Cell International
DOI：10.1186/s12935-021-02041-4
影响因子 ：5.800
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ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p(2020/03/30)
作者：Quan Yuan, Honghao Yu, Jianhua Chen
期刊：Cancer Cell International
DOI：10.1186/s12935-020-01174-2
影响因子 ：5.800
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What role does GPR65 play in the progression of osteosarcoma? Its mechanism and clinical significance(2024/01/13)
作者：Jin Qi, Sihang Liu, Zhirui Zhang
期刊：Cancer Cell International
DOI：10.1186/s12935-024-03216-5
影响因子 ：5.800
引用产品：CL-0360
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A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function(2023/10/03)
作者：Xiuxin Han, Mengfan Yin, Chen Gong
期刊：EXPERT OPINION ON THERAPEUTIC TARGETS
DOI：10.1080/14728222.2023.2263908
影响因子 ：5.800
引用产品：CL-0360
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Solasonine Inhibits Cancer Stemness and Metastasis by Modulating Glucose Metabolism via Wnt/β-Catenin/Snail Pathway in Osteosarcoma(2023/06/28)
作者：Bangjun Wang, Yi Zhou, Peng Zhang
期刊：AMERICAN JOURNAL OF CHINESE MEDICINE
影响因子 ：5.700
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Establishment of a prognostic risk model for osteosarcoma and mechanistic investigation(2024/04/24)
作者：Hongyuan Jiang, Xuliang Zhao, Jinhui Zang
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1399625
影响因子 ：5.600
引用产品：CL-0360
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Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma(2023/01/09)
作者：Zhao Zhang, Zhijie Zhu, Jun Fu
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.109684
影响因子 ：5.600
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Cytotoxic and Antibacterial Meroterpenoids Isolated from the Marine-Derived Fungus Talaromyces sp. M27416(2024/04/20)
作者：Lingzhi Tang, Jinmei Xia, Zhongwei Chen
期刊：Marine Drugs
影响因子 ：5.400
引用产品：CL-0360
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Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling(2023/06/15)
作者：Rujin Xu, Xingyuan Ci, Fang He
期刊：American Journal of Cancer Research
DOI：PMID:37424831
影响因子 ：5.300
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Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1–3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment(2023/06/08)
作者：Song Liao, Jianxiong Li, Song Gao
期刊：Frontiers in Oncology
影响因子 ：4.700
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WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner(2023/03/29)
作者：Qiyong Pan, Jigang Lou, Penghui Yan
期刊：ENVIRONMENTAL TOXICOLOGY
影响因子 ：4.500
引用产品：CL-0360
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hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression(2023/11/18)
作者：Liang Liu, Wenze Huang
期刊：CANCER BIOLOGY & THERAPY
DOI：10.1080/15384047.2023.2274120
影响因子 ：3.600
引用产品：CL-0360
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Hsa_circ_0097271 Knockdown Attenuates Osteosarcoma Progression via Regulating miR-640/MCAM Pathway(2022/10/26)
作者：Peng Sun, Xuan Yang
期刊：DISEASE MARKERS
影响因子 ：3.464
引用产品：CL-0360
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A New 7-azaindole Structure Analog: Molecular Docking, Synthesis and Preliminary Biological Activity in vitro for Anticancer(2022/09/09)
作者：Yifeng Zhan, Hang Tong, Shibo He
期刊：CHEMISTRY & BIODIVERSITY
影响因子 ：2.900
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Farnesyl diphosphate synthase promotes cell proliferation by regulating gene expression and alternative splicing profiles in HeLa cells(2023/02/28)
作者：Lijuan Wang, Zhigang Chen, Dong Chen
期刊：Oncology Letters
影响因子 ：2.900
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Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression(2023/02/21)
作者：Dawei Wang, Yang Wang, Huadong Wang
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子 ：2.900
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Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy(2023/11/22)
作者：Chenyang Meng, Yun Yang, Wei Feng
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-04338-8
影响因子 ：2.600
引用产品：CL-0360
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ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in modulating the malignant biological behavior of osteosarcoma cells(2023/11/29)
作者：Shizhe Li, Jiancheng Xue, He Zhang
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-04406-z
影响因子 ：2.600
引用产品：CL-0360
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Circ_0003732 promotes osteosarcoma progression through regulating miR-377-3p/CPEB1 axis and Wnt/β-catenin signaling pathway(2022/01/01)
作者：Zheng Zhou, Tang Liu, Zhihong Li
期刊：Anti-Cancer Drugs
DOI：10.1097/CAD.0000000000001206
影响因子 ：2.389
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circATP2A2 promotes osteosarcoma progression by upregulating MYH9(2021/11/22)
作者：Xin Cao, Xianfeng Meng, Peng Fu
期刊：Open Medicine
影响因子 ：2.100
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Momordin Ic Inhibits the Partially Malignant Phenotype of Osteosarcoma Cells by Inducing Apoptosis and Autophagy(2024/02/07)
作者：Ruiqing Xu, Rui Huang, Jiandang Shi
期刊：Natural Product Communications
影响因子 ：1.800
引用产品：CL-0360
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Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells(2021/10/18)
作者：Yi Luo, Xu Gao, Luetao Zou
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.000
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