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产品概述
| 名称 | Saos-2 (人成骨肉瘤细胞) (STR鉴定正确) |
| 别称 | SAOS-2; Saos-2; SAOS 2; Saos 2; Saos2; SaOs2; SAOS2; Sarcoma OSteogenic-2; SaOS; SAOS |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:3 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | Saos-2细胞是由J·Fogh和G·Trempe分离和鉴定的众多人肿瘤细胞系中的一种。该病人曾经多种药物治疗，包括RTG、methotrexate、adriamycin vincristine、cytoxan和aramycin-C。Saos-2细胞在免疫抑制小鼠中不致瘤，但在半固体培养基中形成集落。 |
| 年龄（性别） | 女性；11岁 |
| 组织来源 | 骨；骨肉瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肉瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~48 hours |
| 致瘤性 | No, The cells were not tumorigenic in immunosuppressed mice, but did form colonies in semisolid medium. |
| 受体表达情况 | epidermal growth factor (EGF); transforming growth factor beta (Type 1 and Type 2) |
| 抗原表达情况 | Blood Type B, Rh+; HLA A2, A3, Bw16, Bw47 |
| 保藏机构 | ATCC; CRL-7939ATCC; HTB-85 DSMZ; ACC-243 ECACC; 89050205 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10 D2S1338 18 D3S1358 18 D5S818 12 D7S820 8,10 D8S1179 10,12 D13S317 12,13 D16S539 12,13 D18S51 15 D19S433 13 D21S11 28,30 FGA 22,25 PentaD 11,12 PentaE 14,19 TH01 6,9 TPOX 8 vWA 18 D6S1043 11,14 D12S391 20 D2S441 10,14 -
STR鉴定图
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参考文献
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MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm(2021/03/04)
作者：Lifang Hu, Chong Yin, Dong Chen
期刊：cell death and differentiation
DOI：10.1038/s41418-021-00744-9
影响因子 ：12.400
引用产品：CL-0202
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Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells(2023/09/30)
作者：Wenkai Chen, Zongguang Li, Naichun Yu
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-02129-1
影响因子 ：10.200
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Single-Atom Cu Nanozyme-Loaded Bone Scaffolds for Ferroptosis-Synergized Mild Photothermal Therapy in Osteosarcoma Treatment(2024/02/29)
作者：Zuyun Yan, Xin Wu, Wei Tan
期刊：Advanced Healthcare Materials
影响因子 ：10.000
引用产品：CL-0202
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Developing a Versatile Multiscale Therapeutic Platform for Osteosarcoma Synergistic Photothermo-Chemotherapy with Effective Osteogenicity and Antibacterial Capability(2022/09/20)
作者：Yunlong Ma, Lan Jiang, Jie Hu
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
引用产品：CL-0202
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Single-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma(2024/05/17)
作者：Yun Liu, Mingwei He, Haijun Tang
期刊：BMC Medicine
DOI：10.1186/s12916-024-03319-w
影响因子 ：9.300
引用产品：CL-0202
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression(2021/08/26)
作者：Lei Ding, Taiyuan Liu, Yuan Qu
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.08.022
影响因子 ：8.800
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Comprehensive analysis of a glycolysis and cholesterol synthesis-related genes signature for predicting prognosis and immune landscape in osteosarcoma(2022/12/23)
作者：Fangxing Xu, Jinglong Yan, Zhibin Peng
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2022.1096009
影响因子 ：8.786
引用产品：CL-0202
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Osteoporotic bone loss from excess iron accumulation is driven by NOX4-triggered ferroptosis in osteoblasts(2023/02/03)
作者：Hui Zhang, Aifei Wang, Guangfei Li
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2023.01.026
影响因子 ：7.400
引用产品：CL-0202
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Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction(2023/12/15)
作者：Junchao Zhu, Jinghong Yuan, Shahrzad Arya
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1265098
影响因子 ：7.300
引用产品：CL-0202
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Multi-omics analysis reveals cuproptosis and mitochondria-based signature for assessing prognosis and immune landscape in osteosarcoma(2024/01/05)
作者：Chenguang Jia, Mei Liu, Liming Yao
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1280945
影响因子 ：7.300
引用产品：CL-0202
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CKB affects human osteosarcoma progression by regulating the p53 pathway(2022/10/15)
作者：Fengxin Zhou, Xinli Dou, Chenguang Li
期刊：American Journal of Cancer Research
DOI：PMID:36381321
影响因子 ：5.942
引用产品：CL-0202
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy(2019/08/07)
作者：Hongliang Ying, Boda Ying, Jinrui Zhang
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1648280
影响因子 ：5.800
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Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells(2021/10/30)
作者：Rui Zhang, Huan Wang, Erliang Li
期刊：Cancer Cell International
DOI：10.1186/s12935-021-02286-z
影响因子 ：5.800
引用产品：CL-0202
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ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p(2020/03/30)
作者：Quan Yuan, Honghao Yu, Jianhua Chen
期刊：Cancer Cell International
DOI：10.1186/s12935-020-01174-2
影响因子 ：5.800
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A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function(2023/10/03)
作者：Xiuxin Han, Mengfan Yin, Chen Gong
期刊：EXPERT OPINION ON THERAPEUTIC TARGETS
DOI：10.1080/14728222.2023.2263908
影响因子 ：5.800
引用产品：CL-0202
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Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway(2024/01/08)
作者：Ziang Zheng, Xinghan Zhao, Bo Yuan
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-024-00778-y
影响因子 ：5.700
引用产品：CL-0202
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Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling(2023/06/15)
作者：Rujin Xu, Xingyuan Ci, Fang He
期刊：American Journal of Cancer Research
DOI：PMID:37424831
影响因子 ：5.300
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Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells(2020/2/21)
作者：Quan Yuan, Honghao Yu, Jianhua Chen
期刊：OncoTargets and Therapy
影响因子 ：4.000
引用产品：CL-0202
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Down-regulation of PRR11 affects the proliferation, migration and invasion of osteosarcoma by inhibiting the Wnt/β-catenin pathway(2021/09/13)
作者：Ke Li, Hongtao Yu, Chunbing Zhao
期刊：Journal of Cancer
影响因子 ：3.900
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Schisandrin B Inhibits Cell Viability and Migration, and Induces Cell Apoptosis by circ_0009112/miR-708-5p Axis Through PI3K/AKT Pathway in Osteosarcoma(2021/12/22)
作者：Bing Wang, Xiaowei Wang, Xing Tong
期刊：Frontiers in Genetics
影响因子 ：3.700
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hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression(2023/11/18)
作者：Liang Liu, Wenze Huang
期刊：CANCER BIOLOGY & THERAPY
DOI：10.1080/15384047.2023.2274120
影响因子 ：3.600
引用产品：CL-0202
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DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway(2023/02/27)
作者：Mingming Yang, Hang Zhang, Shichang Gao
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-03572-4
影响因子 ：2.600
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Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy(2023/11/22)
作者：Chenyang Meng, Yun Yang, Wei Feng
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-04338-8
影响因子 ：2.600
引用产品：CL-0202
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Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner(2021/12/20)
作者：Tehasi Wang, Chengguang Zhang, Shuren Wang
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-021-02868-7
影响因子 ：2.600
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circATP2A2 promotes osteosarcoma progression by upregulating MYH9(2021/11/22)
作者：Xin Cao, Xianfeng Meng, Peng Fu
期刊：Open Medicine
影响因子 ：2.100
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