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| 名称 | MG-63 (人骨肉瘤细胞) (STR鉴定正确) |
| 别称 | M-G63; MG63 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | MG-63细胞源自14岁患有骨肉瘤的白人男性；聚次黄嘌呤核苷-聚胞嘧啶核苷酸、放线菌酮和放线菌素D可以诱导MG-63细胞产生高水平的干扰素。MG-63细胞表达TGF-β受体Ⅰ和Ⅱ。 |
| 年龄（性别） | 男性；14岁 |
| 组织来源 | 骨；骨肉瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肉瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~28-38 hours |
| 受体表达情况 | transforming growth factor beta (TGF-beta) RI, expressed;transforming growth factor beta (TGF-beta) RII, expressed |
| 基因表达情况 | interferon |
| 保藏机构 | ATCC; CRL-1427 ECACC; 86051601 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,12 D2S1338 17,24 D3S1358 15 D5S818 11,12 D7S820 10 D8S1179 13 D13S317 11 D16S539 11 D18S51 12,16 D19S433 13,14 D21S11 30 FGA 21,25 PentaD 9,13 PentaE 11,12 TH01 9.3 TPOX 8,11 vWA 16,19 D6S1043 12,17 D12S391 15,20 D2S441 10,11 -
STR鉴定图
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参考文献
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Thorium inhibits human respiratory chain complex IV (cytochrome c oxidase)(2022/02/15)
作者：Libing Yu, Zhaozhu Lin, Xuedan Cheng
期刊：Journal of Hazardous Materials
DOI：10.1016/j.jhazmat.2021.127546
影响因子 ：14.224
引用产品：CL-0157
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Chitosan based photothermal scaffold fighting against bone tumor-related complications: Recurrence, infection, and defects(2022/10/26)
作者：Yao Zhao, Xu Peng, Xiaoyang Xu
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2022.120264
影响因子 ：11.200
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Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells(2023/09/30)
作者：Wenkai Chen, Zongguang Li, Naichun Yu
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-02129-1
影响因子 ：10.200
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Janus-Inspired Core–Shell Structure Hydrogel Programmatically Releases Melatonin for Reconstruction of Postoperative Bone Tumor(2023/01/05)
作者：Wei Huang, Xiaoyue Wu, Yifan Zhao
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
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Macroscopic Supramolecular Assembly Strategy to Construct 3D Biocompatible Microenvironments with Site-Selective Cell Adhesion(2021/06/11)
作者：Changyu Wang, Cuiling Lin, Rui Ming
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression(2021/08/26)
作者：Lei Ding, Taiyuan Liu, Yuan Qu
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.08.022
影响因子 ：8.800
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Comprehensive analysis of a glycolysis and cholesterol synthesis-related genes signature for predicting prognosis and immune landscape in osteosarcoma(2022/12/23)
作者：Fangxing Xu, Jinglong Yan, Zhibin Peng
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2022.1096009
影响因子 ：8.786
引用产品：CL-0157
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Anticancer and bone-enhanced nano-hydroxyapatite/gelatin/polylactic acid fibrous membrane with dual drug delivery and sequential release for osteosarcoma(2023/04/13)
作者：Jiaming Liu, Sihui Lin, Jiarui Dang
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2023.124406
影响因子 ：8.200
引用产品：CL-0157
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Dipsacus Asperoides-Derived Exosomes-Like Nanoparticles Inhibit the Progression of Osteosarcoma via Activating P38/JNK Signaling Pathway(2024/02/01)
作者：Jiaxu Lu, Jiaxian Chen, Junhong Ye
期刊：International Journal of Nanomedicine
影响因子 ：8.000
引用产品：CL-0157
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Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect(2022/11/17)
作者：Wenkai Chen, Wenping Lin, Naichun Yu, Linlin Zhang, Zuoxing Wu, Yongjie Chen, Zongguang Li, Fengqing Gong, Na Li, Xiaohui Chen, Xu He, Yue Wu, Xiangchen Zeng, Yuting Yueh, Ren Xu, Guangrong Ji
期刊：International Journal of Nanomedicine
影响因子 ：8.000
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Ziyuglycoside II, a triterpene glycoside compound in Sanguisorbae officinalis L. extract, suppresses metastasis in osteosarcoma via CBX4-mediated Wnt/β-catenin signal pathway(2024/05/09)
作者：Zhewen Deng, Jitong Yuan, Beiting Ma
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.155716
影响因子 ：7.900
引用产品：CL-0157
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Revelation of Adhesive Proteins Affecting Cellular Contractility through A Reference-free Traction Force Microscopy(2024/02/28)
作者：Yingjun Yang, Kuankuan Han, Siyuan Huang
期刊：Journal of Materials Chemistry B
影响因子 ：7.000
引用产品：CL-0157
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Highly stretchable alginate/methylcellulose hydrogels for 3D bio-printing: photopolymerization approach enhancing structural integrity(2024/05/07)
作者：Sorour Sadeghzade, Jinrui Cao, Rui Yang
期刊：GIANT
DOI：10.1016/j.giant.2024.100280
影响因子 ：7.000
引用产品：CL-0157
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CKB affects human osteosarcoma progression by regulating the p53 pathway(2022/10/15)
作者：Fengxin Zhou, Xinli Dou, Chenguang Li
期刊：American Journal of Cancer Research
DOI：PMID:36381321
影响因子 ：5.942
引用产品：CL-0157
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy(2019/08/07)
作者：Hongliang Ying, Boda Ying, Jinrui Zhang
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1648280
影响因子 ：5.800
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Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9(2021/07/14)
作者：Weihang Li, Ziyi Ding, Dong Wang
期刊：Cancer Cell International
DOI：10.1186/s12935-021-02041-4
影响因子 ：5.800
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A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function(2023/10/03)
作者：Xiuxin Han, Mengfan Yin, Chen Gong
期刊：EXPERT OPINION ON THERAPEUTIC TARGETS
DOI：10.1080/14728222.2023.2263908
影响因子 ：5.800
引用产品：CL-0157
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Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway(2024/01/08)
作者：Ziang Zheng, Xinghan Zhao, Bo Yuan
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-024-00778-y
影响因子 ：5.700
引用产品：CL-0157
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8-Methoxyflindersine-Induced Apoptosis and Cell Cycle Disorder Involving MAPK Signaling Activation in Human Colorectal Cancer Cells(2023/04/28)
作者：Dianbao Zhang, Yunmei Fu, Ying Liu
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
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Establishment of a prognostic risk model for osteosarcoma and mechanistic investigation(2024/04/24)
作者：Hongyuan Jiang, Xuliang Zhao, Jinhui Zang
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1399625
影响因子 ：5.600
引用产品：CL-0157
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COPI Vesicle Disruption Inhibits Mineralization via mTORC1-Mediated Autophagy(2023/12/26)
作者：Jiaming Nie, Shaoyang Ma, Yuchen Zhang
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
引用产品：CL-0157
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Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma(2023/01/09)
作者：Zhao Zhang, Zhijie Zhu, Jun Fu
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.109684
影响因子 ：5.600
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MicroRNA PC-3p-2869 Regulates Antler Growth and Inhibits Proliferation and Migration of Human Osteosarcoma and Chondrosarcoma Cells by Targeting CDK8, EEF1A1, and NTN1(2023/06/29)
作者：Fan Yang, Jin Wu, Mindie Zhao
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
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m7G-related genes predict prognosis and affect the immune microenvironment and drug sensitivity in osteosarcoma(2023/08/16)
作者：Zili Lin, Ziyi Wu, Yuhao Yuan
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2023.1158775
影响因子 ：5.600
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Targeted PLK1 suppression through RNA interference mediated by high-fidelity Cas13d mitigates osteosarcoma progression via TGF-β/Smad3 signalling(2024/05/23)
作者：Yi Yuan, Daigui Cao, Anwei Zhang
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：5.300
引用产品：CL-0157
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Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling(2023/06/15)
作者：Rujin Xu, Xingyuan Ci, Fang He
期刊：American Journal of Cancer Research
DOI：PMID:37424831
影响因子 ：5.300
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Network pharmacology-based research on the effect of angelicin on osteosarcoma and the underlying mechanism(2023/06/10)
作者：Yafang Zhang, Junqiang Wei, Lingwei Kong
期刊：Aging-US
影响因子 ：5.200
引用产品：CL-0157
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Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19 accelerates tumor progression through wnt/β-catenin pathway and is upregulated by miR-940 in osteosarcoma(2022/03/17)
作者：Shuhong Liang, Xiaojian Zhang, Jun Li
期刊：Bioengineered
DOI：10.1080/21655979.2022.2040827
影响因子 ：4.900
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Three-dimensional-printed MPBI@β-TCP scaffold promotes bone regeneration and impedes osteosarcoma under near-infrared laser irradiation(2023/04/18)
作者：Liangjie Lu, Huihan Wang, Minjie Yang
期刊：FASEB JOURNAL
影响因子 ：4.800
引用产品：CL-0157
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Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1–3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment(2023/06/08)
作者：Song Liao, Jianxiong Li, Song Gao
期刊：Frontiers in Oncology
影响因子 ：4.700
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Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway(2023/03/05)
作者：Xu Cai, Shaihong Zhu
期刊：Genomics
DOI：10.1016/j.ygeno.2023.110595
影响因子 ：4.400
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RNA-Sequence Reveals the Regulatory Mechanism of miR-149 on Osteoblast Skeleton under Mechanical Tension(2022/09/23)
作者：Yifan Wang, Guanyin Zhu, Fang Pei
期刊：Stem Cells International
影响因子 ：4.300
引用产品：CL-0157
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Osteoblast-derived exosomes promote osteogenic differentiation of osteosarcoma cells via URG4/Wnt signaling pathway(2023/10/11)
作者：Yuanxi Leng, Jingtang Li, Zhisheng Long
期刊：BONE
DOI：10.1016/j.bone.2023.116933
影响因子 ：4.100
引用产品：CL-0157
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Transforming Natural Eggshell and Diatomite into Bioactive Calcium Silicate Material for Bone Regeneration(2024/04/18)
作者：Haiming Yu, Zhihua Liu, Lingying Chen
期刊：ACS Omega
影响因子 ：4.100
引用产品：CL-0157
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3D printed porous PLA/nHA composite scaffolds with enhanced osteogenesis and osteoconductivity in vivo for bone regeneration(2019/09/09)
作者：Xibao Chen, Chunxia Gao, Jiawei Jiang
期刊：Biomedical Materials
影响因子 ：4.000
引用产品：CL-0157
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Long Non-Coding RNA OIP5-AS1 Knockdown Enhances CDDP Sensitivity in Osteosarcoma via miR-377-3p/FOSL2 Axis(2020/5/7)
作者：Ling Liu, Shuya Wang
期刊：OncoTargets and Therapy
影响因子 ：4.000
引用产品：CL-0157
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Down-regulation of PRR11 affects the proliferation, migration and invasion of osteosarcoma by inhibiting the Wnt/β-catenin pathway(2021/09/13)
作者：Ke Li, Hongtao Yu, Chunbing Zhao
期刊：Journal of Cancer
影响因子 ：3.900
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Porphyromonas gingivalis OMVs promoting endothelial dysfunction via the STING pathway in periodontitis(2024/05/02)
作者：Zhenwei Chen, Ye Cao, Wenxiu Jiang
期刊：ORAL DISEASES
影响因子 ：3.800
引用产品：CL-0157
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Caspase-3/GSDME-mediated pyroptosis leads to osteogenic dysfunction of osteoblast-like cells(2023/04/01)
作者：Zhixiao Wu, Qian Ding, Muxin Yue
期刊：Oral Diseases
影响因子 ：3.800
引用产品：CL-0157
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Enterococcus faecalis OG1RF induces apoptosis in MG63 cells via caspase-3/-8/-9 without activation of caspase-1/GSDMD(2021/8/9)
作者：Yang Li, Cheng Wen, Jialin Zhong
期刊：Oral Diseases
影响因子 ：3.800
引用产品：CL-0157
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The effect of resolvin D1 on bone regeneration in a rat calvarial defect model(2022/08/18)
作者：Xiaofeng Jiang, Jing Liu, Si Li
期刊：Journal of Tissue Engineering and Regenerative Medicine
影响因子 ：3.300
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CeO2 Nanoparticle Bioactive Materials Promote MG-63 Osteogenic Differentiation and Antioxidant Activity Through NRF2 Signaling(2023/11/10)
作者：Haijuan Liu, Zidong Wang, Xian Li
期刊：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
DOI：10.1007/s12010-023-04766-6
影响因子 ：3.000
引用产品：CL-0157
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Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression(2023/02/21)
作者：Dawei Wang, Yang Wang, Huadong Wang
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子 ：2.900
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LPS combined with CD47mAb enhances the anti‑osteosarcoma ability of macrophages(2023/03/28)
作者：Peng Yuan, Yukang Que, Yulei Liu
期刊：Oncology Letters
影响因子 ：2.900
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Nanoscale Au@SiO2‑drug/VEGF as an in vivo probe for osteosarcoma diagnosis and therapy(2021/9/8)
作者：Tiangui Chen, Tianbo Li, Jiangning Wang
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0157
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Lithium-incorporated deproteinized bovine bone substitute improves osteogenesis in critical-sized bone defect repair:(2018/4/19)
作者：Hongzhang Guo, Changde Wang, Jixiang Wang
期刊：Journal Of Biomaterials Applications
影响因子 ：2.900
引用产品：CL-0157
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PROSER2 is a poor prognostic biomarker for patients with osteosarcoma and promotes proliferation, migration and invasion of osteosarcoma cells(2022/11/08)
作者：Zhengjiang Li, Yan Zhang, Yongkui Li, Shuxing Xing, Shunqiang Li, Jing Lyu, Zhaonan Ban
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.700
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DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway(2023/02/27)
作者：Mingming Yang, Hang Zhang, Shichang Gao
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-03572-4
影响因子 ：2.600
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Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy(2023/11/22)
作者：Chenyang Meng, Yun Yang, Wei Feng
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-04338-8
影响因子 ：2.600
引用产品：CL-0157
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ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in modulating the malignant biological behavior of osteosarcoma cells(2023/11/29)
作者：Shizhe Li, Jiancheng Xue, He Zhang
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-04406-z
影响因子 ：2.600
引用产品：CL-0157
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Osteocompatible Zinc-Copper Substituted Hydroxyapatite Reinforced Biocomposites for Bone Tissue Regeneration(2024/05/09)
作者：Leixiang Han, Dawei Wang
期刊：Journal of Pharmaceutical Innovation
DOI：10.1007/s12247-024-09833-x
影响因子 ：2.600
引用产品：CL-0157
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Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner(2021/12/20)
作者：Tehasi Wang, Chengguang Zhang, Shuren Wang
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-021-02868-7
影响因子 ：2.600
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Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression(2024/02/29)
作者：Fulin Zhou, Hao Wu, Zhen Yin
期刊：CELLULAR AND MOLECULAR BIOLOGY
影响因子 ：1.600
引用产品：CL-0157
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Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells(2021/10/18)
作者：Yi Luo, Xu Gao, Luetao Zou
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.000
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Verification of Ferroptosis Subcluster-Associated Genes Related to Osteosarcoma and Exploration of Immune Targeted Therapy(2022/09/28)
作者：Mingyang Jiang, Yiji Jike, Fu Gan
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.000
引用产品：CL-0157
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