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| 名称 | HCC1937 (人乳腺癌细胞) (STR鉴定正确) |
| 别称 | HCC-1937 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | HCC1937细胞1995年10月13日最初来源于原发性导管癌，用了11.5个月建株。肿瘤分类为TNMⅡB期，3级。BRCA1分析表明，HCC1937细胞是BRCA 15382C突变纯合的，而来源于同一病人的类淋巴母细胞细胞株在这个突变位点上是杂合的。另两个家庭成员也有这个突变；一个同卵双生姐妹也患有乳腺癌。HCC1937细胞有一个后天的Tp53突变，而其野生型等位基因丢失；一个PTEN基因的后天的纯合缺失，以及多个与乳腺癌发病机理相关的位点上发生的杂合突变。HCC1937细胞Her2-neu和p53表达都呈阴性。HCC1937细胞的上皮细胞特异性标志上皮细胞糖蛋2(EGP2)和细胞角蛋白19都呈阳性；雌激素受体(ER)和孕酮(PR)表达阴性。 |
| 年龄（性别） | 女性；23岁 |
| 组织来源 | 乳房；原发性导管癌；3级，ⅡB期 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 乳腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~50-60 hours |
| 受体表达情况 | estrogen receptor, negative;progesterone receptor, negative |
| 基因表达情况 | Epithelial glycoprotein 2 (EGP2); cytokeratin 19 |
| 保藏机构 | ATCC; CRL-2336 DSMZ; ACC-513 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 25 D3S1358 18 D5S818 12 D7S820 9,10 D8S1179 12,13 D13S317 13 D16S539 13,14 D18S51 12 D19S433 14,15 D21S11 28 FGA 20,22 PentaD 9 PentaE 13 TH01 6 TPOX 11 vWA 16,17 D6S1043 11 D12S391 17.3,21 D2S441 10 -
STR鉴定图
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参考文献
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PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis(2023/06/01)
作者：Zhe Wang, Ruolei Li, Niuniu Ho
期刊：Journal for ImmunoTherapy of Cancer
影响因子 ：10.900
引用产品：CL-0007 CL-0041 CL-0093 CL-0149 CL-0211 CL-0228 CL-0525 CM-0007 CM-0041 CM-0093 CM-0149 CM-0211 CM-0228 CM-0525
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Inhibition of ATM promotes PD-L1 expression by activating JNK/c-Jun/TNF-α signaling axis in triple-negative breast cancer(2024/01/24)
作者：Chenying Liu, Xiaolong Qian, Chunyan Yu
期刊：CANCER LETTERS
DOI：10.1016/j.canlet.2024.216642
影响因子 ：9.700
引用产品：CL-0093
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Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer(2024/01/10)
作者：Yanqin Tan, Hui Guo, Shuwei Zhang
期刊：npj Precision Oncology
DOI：10.1038/s41698-023-00489-3
影响因子 ：7.900
引用产品：CL-0093
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Oxypalmatin regulates proliferation and apoptosis of breast cancer cells by inhibiting PI3K/AKT signaling and its efficacy against breast cancer organoids(2023/03/10)
作者：Xian Lin, Dong Chen, Xinyu Chu
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.154752
影响因子 ：7.900
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Metabolome Sequencing Reveals that Protein Arginine-N-Methyltransferase 1 Promotes the Progression of Invasive Micropapillary Carcinoma of the Breast and Predicts a Poor Prognosis(2023/06/09)
作者：Kailiang Wu, Weidong Li, Hanjiao Liu
期刊：AMERICAN JOURNAL OF PATHOLOGY
DOI：10.1016/j.ajpath.2023.05.010
影响因子 ：6.000
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Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer(2023/10/27)
作者：Keying Liang, Qian Wang, Li Qiu
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
引用产品：CL-0093
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Leveraging senescence-oxidative stress co-relation to predict prognosis and drug sensitivity in breast invasive carcinoma(2023/08/04)
作者：Yinghui Ye, Yulou Luo, Tong Guo, Chenguang Zhang, Yutian Sun, Anping Xu, Ling Ji, Jianghua Ou, Shang Ying Wu
期刊：Frontiers in Endocrinology
DOI：10.3389/fendo.2023.1179050
影响因子 ：5.200
引用产品：CL-0093 CL-0149 CL-0324 CL-0726 CM-0093 CM-0149 CM-0324 CM-0726
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Triple-Negative Breast Cancer Intrinsic FTSJ1 Favors Tumor Progression and Attenuates CD8+ T Cell Infiltration(2024/01/31)
作者：Yangqing Sun, Qingqing Liu, Shangwei Zhong
期刊：Cancers
影响因子 ：5.200
引用产品：CL-0093
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Constructing a novel prognostic model for triple-negative breast cancer based on genes associated with vasculogenic mimicry(2024/05/08)
作者：Yu Ren, Luyi Feng, Zhihua Tan
期刊：Aging-US
影响因子 ：5.200
引用产品：CL-0093
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LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability(2021/11/05)
作者：Pengping Li, Rongguo Li, Yuqing Huang
期刊：Aging-US
影响因子 ：5.200
引用产品：CL-0093
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Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint(2021/11/08)
作者：Meiran Chu, Xinglan An, Daoyu Zhang
期刊：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
DOI：10.1016/j.bbamcr.2021.119169
影响因子 ：5.100
引用产品：CL-0093
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Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors(2024/04/04)
作者：Jialin Zhang, Gengshen Yin, Chunmiao Ye
期刊：Chinese Journal of Cancer Research
DOI：10.21147/j.issn.1000-9604.2024.02.03
影响因子 ：5.100
引用产品：CL-0093
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The dePARylase NUDT16 promotes radiation resistance of cancer cells by blocking SETD3 for degradation via reversing its ADP-ribosylation(2024/01/22)
作者：Weijun Wu, Wenjing Wu, Yingshi Zhou
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 ：4.800
引用产品：CL-0093
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Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway(2020/10/30)
作者：Daoyu Zhang, Xinglan An, Qi Li
期刊：Frontiers in Oncology
影响因子 ：4.700
引用产品：CL-0093
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Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines(2024/03/21)
作者：Lijie Zhu, Binzhuo Liu, Feng Jin
期刊：MOLECULES
影响因子 ：4.600
引用产品：CL-0093
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Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells(2023/12/08)
作者：Ming Lei, Yunlong Zhang, Fengying Huang
期刊：Scientific Reports
DOI：10.1038/s41598-023-49136-8
影响因子 ：4.600
引用产品：CL-0093
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Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis(2023/02/06)
作者：Jiacheng Li, Xiaozhen Liu, Lin Chen
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116415
影响因子 ：3.800
引用产品：CL-0007 CL-0093 CL-0149 CL-0150 CL-0152 CL-0290 CL-0525
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RAMP2-AS1 inhibits CXCL11 expression to suppress malignant phenotype of breast cancer by recruiting DNMT1 and DNMT3B(2022/04/04)
作者：Li Li, Yaping Gan, Hui Peng
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2022.113139
影响因子 ：3.700
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Prognosis stratification of patients with breast invasive carcinoma based on cysteine metabolism-disulfidptosis affinity(2023/07/08)
作者：Yuting Zhang, Yinghui Ye, Anping Xu
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-023-05028-y
影响因子 ：3.600
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