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产品概述
| 名称 | MDA-MB-468 (人乳腺癌细胞) (STR鉴定正确) |
| 别称 | MDA-MB 468; MDA-MB468; MDAMB468; MDA-468; MDA468; MB468; MD Anderson-Metastatic Breast-468 |
| 种属 | 人类 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，100%, 温度：37℃
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| 培养方案B（可选） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 1.该细胞推荐使用Leibovitz's L-15培养基进行培养，Leibovitz's L-15不可以通入二氧化碳，会产生细胞毒性；2.如您没有无二氧化碳的培养箱，可使用DMEM替代Leibovitz's L-15，使用DMEM培养基时即可正常通入5%二氧化碳；3.配套专用培养基默认Leibovitz's L-15配置，如需DMEM配方，请联系销售下单备注更改。4.该细胞培养过程中会分泌少量黑色颗粒物，不影响细胞生长，属正常现象。 |
| 背景描述 | MDA-MB-468细胞是由Cailleau·R等人于1977年从一位患有转移性乳腺癌的51岁黑人女性的胸腔积液中分离得到的。虽然供体组织的G6PD等位基因杂合，但MDA-MB-468细胞始终表现为G6PD A表型。p53MDA-MB-468细胞是由Cailleau·R等人于1977年从一位患有转移性乳腺癌的51岁黑人女性的胸腔积液中分离得到的。虽然供体组织的G6PD等位基因杂合，但MDA-MB-468细胞始终表现为G6PD A表型。p53基因273位密码子存在G→A突变，从而导致Arg→His替代。每个MDA-MB-468细胞上存在1×10^6个EGF受体。 |
| 年龄（性别） | 女性，51岁 |
| 组织来源 | 乳腺；乳房；腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 乳腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~36-62 hours |
| 致瘤性 | Yes, in nude mice inoculated subcutaneously with 1×10^7 cells.(Tumors developed within 21 days at 100% frequency (5/5).) |
| 受体表达情况 | epidermal growth factor (EGF); transforming growth factor alpha (TGF alpha) |
| 抗原表达情况 | Blood Type AB; HLA Aw23, Aw30, B27, Bw35, Cw2, Cw4 (patient) |
| 保藏机构 | ATCC; HTB-132 DSMZ; ACC-738 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 17,25 D3S1358 15 D5S818 12 D7S820 8 D8S1179 13 D13S317 12 D16S539 9 D18S51 17 D19S433 12,13 D21S11 27,28 FGA 23 PentaD 8,10 PentaE 5 TH01 7 TPOX 8,9 vWA 18 D6S1043 13,23 D12S391 18 D2S441 12,14 -
STR鉴定图
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参考文献
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Microfluidic Impedance Cytometry Enabled One-Step Sample Preparation for Efficient Single-Cell Mass Spectrometry(2024/03/14)
作者：Junwen Zhu, Siyuan Pan, Huichao Chai
期刊：Small
影响因子 ：13.300
引用产品：CL-0290
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Antitumor effect of CAR-T cells targeting transmembrane tumor necrosis factor alpha combined with PD-1 mAb on breast cancers(2023/01/01)
作者：Hongping Ba, Zigang Dai, Zunyue Zhang
期刊：Journal for ImmunoTherapy of Cancer
影响因子 ：10.900
引用产品：CL-0290
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MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis(2021/04/06)
作者：Fengxia Chen, Qingqing Wang, Xiaoyan Yu
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03661-4
影响因子 ：9.000
引用产品：CL-0005 CL-0041 CL-0114 CL-0150 CL-0290 CL-0525 PM150312B
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TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9(2024/03/19)
作者：Ran Hu, Yu Cao, Yuanyuan Wang
期刊：BREAST CANCER RESEARCH
DOI：10.1186/s13058-024-01802-z
影响因子 ：7.400
引用产品：CL-0290
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UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5(2024/03/11)
作者：Juan Li, Yu Liang, Shijie Zhou
期刊：BREAST CANCER RESEARCH
DOI：10.1186/s13058-024-01800-1
影响因子 ：7.400
引用产品：CL-0290
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Identifying SLC2A6 as the novel protective factor in breast cancer by TP53-related genes affecting M1 macrophage infiltration(2024/04/16)
作者：Chao Dai, Yuxin Man, Luhan Zhang
期刊：APOPTOSIS
DOI：10.1007/s10495-024-01964-3
影响因子 ：7.200
引用产品：CL-0290
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SLC35A2 expression drives breast cancer progression via ERK pathway activation(2023/12/24)
作者：Xiaochen Yang, Yukai Tao, Yan Xu
期刊：FEBS Journal
影响因子 ：5.400
引用产品：CL-0290
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Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis | Molecular and Cellular Biology(2021/09/24)
作者：Yihong Huang, Shuo Zheng, Ying Lin, Liming Kea
期刊：Molecular And Cellular Biology
影响因子 ：5.300
引用产品：164210 CL-0041 CL-0150 CL-0152 CL-0290 CL-0525 PB180120 PM150110 PM151010
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Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis(2023/03/03)
作者：Yihong Huang, Shuo Zheng, Ying Lin
期刊：MOLECULAR AND CELLULAR BIOLOGY
影响因子 ：5.300
引用产品：CL-0290
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The Curcumin Analog EF24 Inhibits Proliferation and Invasion of Triple-Negative Breast Cancer Cells by Targeting the Long Noncoding RNA HCG11/Sp1 Axis(2023/02/27)
作者：Yin Duan, Huiling Chen, Min Ling
期刊：MOLECULAR AND CELLULAR BIOLOGY
影响因子 ：5.300
引用产品：CL-0290
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The curcumin analog EF24 inhibits proliferation and invasion of triple-negative breast cancer cells by targeting the lncRNA HCG11/Sp1 axis | Molecular and Cellular Biology(2021/11/15)
作者：Yin Duan, Huiling Chen, Min Ling
期刊：Molecular And Cellular Biology
影响因子 ：5.300
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Baicalein promotes KDM4E to induce BICD1 and inhibit triple-negative breast cancer progression by blocking PAR1 signaling(2024/04/12)
作者：Yun Dong, Gaojian He, Kun Chen
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23724
影响因子 ：4.600
引用产品：CL-0290
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Tubulin alpha-1b chain was identified as a prognosis and immune biomarker in pan-cancer combing with experimental validation in breast cancer(2024/04/08)
作者：Yiyang Wang, Yongxiang Li, Yubo Jing
期刊：Scientific Reports
DOI：10.1038/s41598-024-58982-z
影响因子 ：4.600
引用产品：CL-0290
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Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis(2023/02/06)
作者：Jiacheng Li, Xiaozhen Liu, Lin Chen
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116415
影响因子 ：3.800
引用产品：CL-0007 CL-0093 CL-0149 CL-0150 CL-0152 CL-0290 CL-0525
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Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer(2020/12/13)
作者：Lin Niu, Songhe Yang, Xueying Zhao
期刊：Molecular Medicine Reports
影响因子 ：3.400
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Inhibitory impact of cinobufagin in triple-negative breast cancer metastasis: involvements of macrophage reprogramming through upregulated MME and inactivated FAK/STAT3 signaling(2024/01/26)
作者：Zhaohui Zhu, Hanlu Wang, Xu Qian
期刊：Clinical Breast Cancer
DOI：10.1016/j.clbc.2024.01.014
影响因子 ：3.100
引用产品：CL-0290
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Identification of TFR2 as a novel ferroptosis‑related gene that serves an important role in prognosis and progression of triple‑negative breast cancer(2023/12/05)
作者：Yan Yang, Jie Du, Yunfei Huang
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0290
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Zinc finger protein 468 up-regulation of TFAM contributes to the malignant growth and cisplatin resistance of breast cancer cells(2024/03/01)
作者：Zhaoyang Jia, Feng Wang, Gongzhuo Li
期刊：Cell Division
DOI：10.1186/s13008-024-00113-1
影响因子 ：2.300
引用产品：CL-0290
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Docetaxel-resistant triple-negative breast cancer cell-derived exosomal lncRNA LINC00667 reduces the chemosensitivity of breast cancer cells to docetaxel via targeting miR-200b-3p/Bcl-2 axis(2022/10/25)
作者：Jindong Li, Jie Kang, Weiyan Liu
期刊：EUROPEAN JOURNAL OF HISTOCHEMISTRY
影响因子 ：1.966
引用产品：CL-0290
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