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| 名称 | HL-60 (人原髓细胞白血病细胞) (STR鉴定正确) |
| 别称 | HL 60; HL60 |
| 种属 | 人 |
| 生长特性 | 悬浮细胞 |
| 细胞形态 | 原粒细胞 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 3×10^5-5×10^5cells/mL |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞为悬浮细胞，请注意离心收集细胞悬液；请勿直接倒掉细胞培养液。 |
| 背景描述 | HL-60细胞是一株早幼粒细胞；HL-60细胞源自一位患有急性粒-单核细胞白血病的36岁白人女性。HL-60细胞自发分化，丁酸盐、次黄嘌呤、佛波醇、肉豆蔻酸、DMSO(1%-1.5%)、放线菌素D和视黄酸均可以促进分化。HL-60细胞表现出吞噬活性，并对趋化刺激有响应；HL-60细胞致癌基因myc表达阳性。 |
| 年龄（性别） | 女性；36岁 |
| 组织来源 | 外周血；早幼粒细胞；急性粒－单核细胞白血病 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 白血病细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~28-40 hours |
| 致瘤性 | Yes, in nude mice (subcutaneous myeloid tumors).Yes, in semi-solid media. |
| 受体表达情况 | complement, expressed;Fc, expressed |
| 基因表达情况 | tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid, myc+ |
| 保藏机构 | ATCC; CCL-240 BCRC; 60027 BCRJ; 0104 DSMZ; ACC-3 ECACC; 98070106 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 13,14 D2S1338 17 D3S1358 16 D5S818 12 D7S820 11,12 D8S1179 12,13 D13S317 8,11 D16S539 11 D18S51 14,15 D19S433 14 D21S11 29,30 FGA 21,22,23,24 PentaD 10,12 PentaE 13,14 TH01 7,8 TPOX 8,11 vWA 16 D6S1043 12 D12S391 18,20 D2S441 10,14 -
STR鉴定图
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参考文献
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Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS(2024/03/12)
作者：Changchang Xu, Lin Zhang, Shaoyu Xu
期刊：Cellular & Molecular Immunology
DOI：10.1038/s41423-024-01146-w
影响因子 ：24.100
引用产品：CL-0110
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CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients(2023/09/22)
作者：Jiaoling Chen, Yaxing Bai, Ke Xue
期刊：Nature Communications
DOI：10.1038/s41467-023-41484-3
影响因子 ：16.600
引用产品：CL-0110
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Ozone-delivering nanocomposite hydrogel for acute Staphylococcus aureus osteomyelitis treatment via neutrophil regulation(2024/04/10)
作者：Hangtian Wu, Yihuang Lin, Yanpeng Lin
期刊：CHEMICAL ENGINEERING JOURNAL
影响因子 ：15.100
引用产品：CL-0110
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The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability(2022/02/25)
作者：Nan Zhang, Shen Yan, Huan Li
期刊：Experimental And Molecular Medicine
DOI：10.1038/s12276-022-00735-x
影响因子 ：12.800
引用产品：CL-0110
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Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis(2024/02/02)
作者：Fangfei Wang, Feng Zhou, Jianxiang Peng
期刊：Redox Biology
DOI：10.1016/j.redox.2024.103072
影响因子 ：11.400
引用产品：CL-0110
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Oligomer-guided recognition of two fucan sulfate from Bohadschia argus and inhibition of P-selectin binding to its ligand(2023/06/01)
作者：Dilihumaer Ruzemaimaiti, Huifang Sun, Jiali Zhang
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2023.121080
影响因子 ：11.200
引用产品：CL-0110
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A PET Probe Targeting Polyamine Transport System for Precise Tumor Diagnosis and Therapy(2024/04/25)
作者：Ming Zhou, Xiaoqin Yin, Bei Chen
期刊：Asian Journal of Pharmaceutical Sciences
DOI：10.1016/j.ajps.2024.100924
影响因子 ：10.200
引用产品：CL-0110
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LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit(2021/05/18)
作者：Yanling Tao, Jingjing Zhang, Lulu Chen
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03767-9
影响因子 ：9.000
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METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling(2023/03/14)
作者：Shuhua Luo, Chaoxiong Liao, Lina Zhang
期刊：Cell Reports
DOI：10.1016/j.celrep.2023.112259
影响因子 ：8.800
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Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D(2023/12/23)
作者：Liting Zhou, Yuanyuan Li, Jiayi You
期刊：INFLAMMATION RESEARCH
DOI：10.1007/s00011-023-01818-9
影响因子 ：6.700
引用产品：CL-0110
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Neural network-enhanced real-time impedance flow cytometry for single-cell intrinsic characterization(2022/1/18)
作者：Yongxiang Feng, Zhen Cheng, Huichao Chai
期刊：LAB ON A CHIP
影响因子 ：6.100
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RAB3D/MDM2/β-catenin/c-MYC axis exacerbates the malignant behaviors of acute myeloid leukemia cells in vitro and in vivo(2022/10/24)
作者：Jian Liu, Yumiao Mai, Yingjie Wang
期刊：CANCER GENE THERAPY
DOI：10.1038/s41417-022-00549-z
影响因子 ：5.854
引用产品：CL-0110
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Multiomic Landscape of Immune Pathogenesis in Kimura’s Disease(2023/04/01)
作者：Xunyao Wu, Anqi Wang, Sumei Zhang
期刊：iScience
DOI：10.1016/j.isci.2023.106559
影响因子 ：5.800
引用产品：CL-0110
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Assessing immune hepatotoxicity of troglitazone with a versatile liver-immune-microphysiological-system(2024/05/30)
作者：Quanfeng Deng, Youlong Yang, Yuangui Liu
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1335836
影响因子 ：5.600
引用产品：CL-0110
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Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia(2023/02/01)
作者：Hao Zhang, Wenjun Song, Xinying Ma
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 ：4.800
引用产品：CL-0110
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Comprehensive analysis of ferroptosis-related gene signatures as a potential therapeutic target for acute myeloid leukemia: A bioinformatics analysis and experimental verification(2022/08/11)
作者：Zhiyuan Zheng, Xiaoying Hong, Xiaoxue Huang
期刊：Frontiers in Oncology
影响因子 ：4.700
引用产品：CL-0110
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Estrone-targeted liposomes for mitoxantrone delivery via estrogen receptor: In vivo targeting efficacy, antitumor activity, acute toxicity and pharmacokinetics(2021/03/02)
作者：Guoxing Xu, Huan Tang, Jinglin Chen
期刊：European Journal Of Pharmaceutical Sciences
DOI：10.1016/j.ejps.2021.105780
影响因子 ：4.600
引用产品：CL-0110
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Neutrophil-to-lymphocyte ratio in colorectal tissue affects prognosis in patients with colorectal cancer(2024/05/15)
作者：Feng Xun, Wenliang Jiang, Min Sha
期刊：PATHOLOGY
DOI：10.1016/j.pathol.2024.03.003
影响因子 ：4.500
引用产品：CL-0110
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Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells: hsa_circ_0013880/USP32/Rap1b in acute myeloid leukemia(2023/03/23)
作者：Heyang Zhang, Yuan Tao, Xin Ding
期刊：ACTA BIOCHIMICA ET BIOPHYSICA SINICA
影响因子 ：3.700
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Oestrone‐targeted liposomes for mitoxantrone delivery via oestrogen receptor – synthesis, physicochemical characterization and in‐vitro evaluation(2017/04/26)
作者：Qiang Hao, Guoxing Xu, Yue Yang
期刊：Journal of Pharmacy and Pharmacology
影响因子 ：3.300
引用产品：CL-0110
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Hyposterolactone A, a 3α-Hydroxy Steroidal Lactone from the Deep-Sea-Derived Fungus Hypocrea sp. ZEN14(2023/06/02)
作者：Lin Xu, Huabin Ma, Taizong Wu
期刊：CHEMISTRY & BIODIVERSITY
影响因子 ：2.900
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High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression(2024/05/09)
作者：Aohang Li, Jingxuan Wu
期刊：Open Medicine
影响因子 ：2.100
引用产品：CL-0110
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CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis(2023/06/05)
作者：Jiao Wang, Cuiping Wu, Weilun Zhou
期刊：Hematology
DOI：10.1080/16078454.2023.2220522
影响因子 ：1.900
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Artesunate reverses cytarabine resistance in acute myeloid leukemia by blocking the JAK/STAT3 signaling(2023/10/10)
作者：Qiong Su, Pei Huang, Xi Luo
期刊：Hematology
DOI：10.1080/16078454.2023.2255802
影响因子 ：1.900
引用产品：CL-0110
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A Novel Phenoxazine-based Fluorescent Probe for the Detection of HOCl in Living Cells(2020/5/5)
作者：Jiajia Yang, Yusi Yao, Yang Shen
期刊：Zeitschrift Fur Anorganische Und Allgemeine Chemie
影响因子 ：1.400
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