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| 名称 | U-937 (人组织细胞淋巴瘤细胞) (STR鉴定正确) |
| 别称 | U937; U 937 |
| 种属 | 人 |
| 生长特性 | 悬浮细胞 |
| 细胞形态 | 单核细胞 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 3×10^5-5×10^5cells/mL |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞为悬浮细胞，请注意离心收集细胞悬液；请勿直接倒掉细胞培养液。 |
| 背景描述 | U-937细胞是由Sundstrom和Nilsson于1974年建立，取材于患组织细胞淋巴瘤病人的胸水。研究表明：U-937细胞能被人混合淋巴细胞培养上清，佛波脂、维生素D3、γ干扰素、肿瘤坏死因子和维甲酸诱导终末单核细胞分化。U-937细胞免疫球蛋白产物和EB病毒表达为阴性；U-937细胞表达Fas抗原且对TNF和抗-Fas抗体敏感。 |
| 年龄（性别） | 男性 |
| 组织来源 | 组织细胞淋巴瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 淋巴瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~30-60 hours |
| 受体表达情况 | complement (C3) |
| 基因表达情况 | lysozyme; beta-2-microglobulin (beta 2 microglobulin); tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid (PMA) |
| 保藏机构 | ATCC; CRL-1593ATCC; CRL-1593.2 DSMZ; ACC-5 ECACC; 85011440 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 17,20 D3S1358 16 D5S818 12 D7S820 9,11 D8S1179 12,13 D13S317 10,12 D16S539 12 D18S51 13,14 D19S433 14,16 D21S11 27,29 FGA 22,25 PentaD 12,13 PentaE 13 TH01 6,9.3 TPOX 8,11 vWA 14,15 D6S1043 12,18 D12S391 17,18 D2S441 10 -
STR鉴定图
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参考文献
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Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues(2024/02/15)
作者：Jian Wu, Chaoye Wang, Shuhui Sun
期刊：Protein & Cell
影响因子 ：21.100
引用产品：CL-0239
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An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy(2020/08/20)
作者：Hui Wang, Qian Xu, Chanyuan Zhao
期刊：Journal for ImmunoTherapy of Cancer
影响因子 ：10.900
引用产品：CL-0239
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miR-223-3p Prevents Necroptotic Macrophage Death by Targeting Ripk3 in a Negative Feedback Loop and Consequently Ameliorates Advanced Atherosclerosis(2023/11/16)
作者：Yunhui Jia, Lianping Cheng, Jiaxuan Yang
期刊：ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
DOI：10.1161/ATVBAHA.123.319776
影响因子 ：8.700
引用产品：CL-0239
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Label-free, rapid and highly accurate identification and categorization of leukemia cells via Raman spectroscopy(2023/08/22)
作者：Luyue Jiang, Matthew Xinhu Ren, Gang Niu, Jingang Shi, Xinhao Cao, Yan Duan, Heping Wu, Zhen Xie, Yi Quan, Libo Zhao, Zhuangde Jiang, Yihong Gong, Wei Ren, Gang Zhao
期刊：SENSORS AND ACTUATORS B-CHEMICAL
影响因子 ：8.400
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Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway(2022/10/18)
作者：Hanyue Li, Yu Yuan, Hongying Chen
期刊：Molecular Metabolism
DOI：10.1016/j.molmet.2022.101617
影响因子 ：8.100
引用产品：CL-0239
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Scaffold hopping derived novel benzoxazepinone receptor-interacting protein kinase 1 (RIP1) inhibitors as anti-necroptosis agents: Anti-inflammatory effect in systemic inflammatory response syndrome (SIRS) and epilepsy(2024/03/09)
作者：Ruiqi Jiang, Bin Xu, Shumeng Zhi
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2024.116304
影响因子 ：6.700
引用产品：CL-0239
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RAB3D/MDM2/β-catenin/c-MYC axis exacerbates the malignant behaviors of acute myeloid leukemia cells in vitro and in vivo(2022/10/24)
作者：Jian Liu, Yumiao Mai, Yingjie Wang
期刊：CANCER GENE THERAPY
DOI：10.1038/s41417-022-00549-z
影响因子 ：5.854
引用产品：CL-0239
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High-glucose conditions attenuate the response of macrophages to Legionella pneumophila infection by inhibiting NOD1 and MAPK signaling(2024/05/15)
作者：Yuting Zhang, Sicong Liang, Ze Deng
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.112254
影响因子 ：5.600
引用产品：CL-0239
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Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-κB P65 signalling activation(2022/09/07)
作者：Peng Liu, Shuya Wang, Guangxin Wang
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：5.300
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miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population(2018/11/29)
作者：Suli Huang, Ziquan Lv, Ying Wen
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.300
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Discovery of novel 5-phenylpyrazol receptor interacting protein 1(RIP1) kinase inhibitors as anti-necroptosis agents by combining virtual screening and in vitro and in vivo experimental evaluations(2023/11/11)
作者：Ying Shi, Jiaqin Tang, Shumeng Zhi
期刊：BIOORGANIC CHEMISTRY
DOI：10.1016/j.bioorg.2023.106964
影响因子 ：5.100
引用产品：CL-0239
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MicroRNA-124a contributes to glucocorticoid resistance in acute-on-chronic liver failure by negatively regulating glucocorticoid receptor alpha(2019/10/01)
作者：Xin Wang, Hongrui Xu, Yadong Wang
期刊：Annals of Hepatology
DOI：10.1016/j.aohep.2019.08.007
影响因子 ：3.800
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Identification of Blood Let-7e-5p as a Biomarker for Ischemic Stroke(2016/10/24)
作者：Suli Huang, Ziquan Lv, Yi Guo
期刊：PLoS One
DOI：10.1371/journal.pone.0163951
影响因子 ：3.700
引用产品：CL-0239
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Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells: hsa_circ_0013880/USP32/Rap1b in acute myeloid leukemia(2023/03/23)
作者：Heyang Zhang, Yuan Tao, Xin Ding
期刊：ACTA BIOCHIMICA ET BIOPHYSICA SINICA
影响因子 ：3.700
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Matrisome provides a supportive microenvironment for oral squamous cell carcinoma progression(2021/12/16)
作者：Yungang He, Pingmeng Deng, Ying Yan
期刊：Journal of Proteomics
DOI：10.1016/j.jprot.2021.104454
影响因子 ：3.300
引用产品：CL-0239
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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization(2024/04/15)
作者：Xuanzeng Pei, Min Cai, Dawei Jiang
期刊：World Journal of Gastrointestinal Oncology
影响因子 ：3.000
引用产品：CL-0239
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Gastrodin Suppresses the Progression of Atherosclerosis and Vascular Inflammation by Regulating TLR4/NF‐κB Pathway(2024/01/25)
作者：Bing Dai, Cunfa Liu, Song Zhang
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-024-01218-8
影响因子 ：2.600
引用产品：CL-0239
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Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2(2024/04/10)
作者：Guofu Li, Ziyu Xiong, Ying Li
期刊：Discover Oncology
DOI：10.1007/s12672-024-00963-9
影响因子 ：2.200
引用产品：CL-0239
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Calycosin Induces Ferroptosis by SLC7A11 Through the PI3K/Akt Pathway in Acute Myelocytic Leukemia(2024/03/04)
作者：Chaoping Xu, Wei Chang, Hui Jiang
期刊：Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
DOI：10.1007/s43450-023-00502-7
影响因子 ：1.600
引用产品：CL-0239
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Human EVI2B acts as a Janus-faced oncogene/antioncogene by differently affecting as per cancer type neoplastic cells growth and immune infiltration:(2023/03/23)
作者：Fangyingnan Zhang, Xinning Wang, Xiaoqi Zhang
期刊：Oncologie
DOI：10.1515/oncologie-2022-1002
影响因子 ：0.900
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