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产品概述
名称 | Hepa 1-6 (小鼠肝癌细胞) (STR鉴定正确) |
别称 | HEPA 1-6; Hepa1-6 |
种属 | 小鼠 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:3-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | Hepa 1-6细胞是C57/L小鼠中产生的BW7756小鼠肝癌的衍生株。 |
年龄(性别) | 雌性 |
组织来源 | 肝;肝癌 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肝胆癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~24-30 hours |
基因表达情况 | albumin, alpha fetoprotein (AFP, alpha-fetoprotein); albumin; alpha 1 antitrypsin (alpha-1-antitrypsin); amylase |
保藏机构 | ATCC; CRL-1830 BCRC; 60051 DSMZ; ACC-175 ECACC; 92110305 |
STR鉴定
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STR位点信息
18-3 16,17 6-7 15 5-5 17 X-1 25 1-2 13 7-1 25.2 8-1 15 1-1 14,15,16 19-2 10,11 15-3 17,18,19 12-1 17 6-4 18,19 4-2 18.3,19.3 3-2 10 2-1 14 13-1 17.2
11-2 16 17-2 14 -
STR鉴定图
参考文献
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Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells(2019/10/31)
作者:Junyu Xiang, Ni Zhang, Juan Feng
期刊:Gastroenterology
DOI:10.1053/j.gastro.2019.10.025
影响因子 :29.400
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Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy(2019/10/22)
作者:Huiya Huang,Yiqi Liu, Weixi Liao
期刊:Nature Communications
DOI:10.1038/s41467-019-12794-2
影响因子 :16.600
引用产品:CL-0105
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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner(2023/02/03)
作者:Yiru Long, Runqiu Chen, Xiaolu Yu
期刊:Cancer Immunology Research
DOI:10.1158/2326-6066.CIR-22-0439
影响因子 :10.100
引用产品:CL-0005 CL-0007 CL-0019 CL-0071 CL-0105 CL-0129 CL-0140 CL-0196 CL-0246 CL-0319
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The spatial and single-cell analysis reveals remodeled immune microenvironment induced by synthetic oncolytic adenovirus treatment(2023/11/24)
作者:Gan Liu, Qifan Hu, Shuguang Peng
期刊:CANCER LETTERS
DOI:10.1016/j.canlet.2023.216485
影响因子 :9.700
引用产品:CL-0105
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LncRNA CRNDE Drives the Progression of Hepatocellular Carcinoma by inducing the Immunosuppressive Niche(2024/01/01)
作者:Xianying Li, Shuhang Liang, Mingming Fei
期刊:International Journal of Biological Sciences
影响因子 :9.200
引用产品:CL-0105
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Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling(2021/10/03)
作者:Qi Han, Huiling Chen, Likai Wang
期刊:International Journal of Biological Sciences
影响因子 :9.200
引用产品:CL-0105
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Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells(2019/10/07)
作者:Hongwei Wang, Yan Zhang, Panpan Tan
期刊:Environmental Pollution
DOI:10.1016/j.envpol.2019.113359
影响因子 :8.900
引用产品:CL-0105
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Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma(2022/08/22)
作者:Shasha Shi, Huipu Li, Xi Zheng
期刊:Materials Today Bio
DOI:10.1016/j.mtbio.2022.100398
影响因子 :8.200
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Improved anti-hepatocellular carcinoma effect by enhanced Co-delivery of Tim-3 siRNA and sorafenib via multiple pH triggered drug-eluting nanoparticles(2022/07/06)
作者:Chenghua Song, Jia Zhang, Ruichao Wen
期刊:Materials Today Bio
DOI:10.1016/j.mtbio.2022.100350
影响因子 :8.200
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Synergistic Effects of Nanoscale CaO2 Combined with PD-1 Inhibitors in the Treatment of Hepatocellular Carcinoma: A Promising Combination(2023/01/04)
作者:Yingliang Wang, Shuguang Ju, Huimin Zhou
期刊:International Journal of Nanomedicine
影响因子 :8.000
引用产品:CL-0105
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Sono-Immunotherapy Mediated Controllable Composite Nano Fluorescent Probes Reprogram the Immune Microenvironment of Hepatocellular Carcinoma(2023/10/25)
作者:Yichi Chen, Bolin Wu, Haitao Shang
期刊:International Journal of Nanomedicine
影响因子 :8.000
引用产品:CL-0105
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NME4 mediates metabolic reprogramming and promotes nonalcoholic fatty liver disease progression(2023/12/14)
作者:Shaofang Xie,Lei Yuan,Yue Sui
期刊:EMBO REPORTS
DOI:10.1038/s44319-023-00012-6
影响因子 :7.700
引用产品:CL-0105
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Tumor cell density dependent IL-8 secretion induces the fluctuation of tregs/CD8 + T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpoint(2023/03/17)
作者:Mengchao Yan, Jia Yao, Yan Lin
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-023-04060-3
影响因子 :7.400
引用产品:CL-0105
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Protein-Gold Nanoclusters Loaded with Ferrous Ions for Inducing Ferroptosis of Hepatoma Cells(2023/04/05)
作者:Chunyan Jiang, Xin Liu, Zhenhua Li
期刊:Advanced Materials Technologies
影响因子 :6.800
引用产品:CL-0105
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Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis(2023/08/23)
作者:Fangming Liu, Yuting Wu, Baohui Zhang
期刊:CHINESE MEDICAL JOURNAL
DOI:10.1097/CM9.0000000000002816
影响因子 :6.100
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Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1(2021/2/26)
作者:Meng Wang, Haoyu Liu, Xu Zhang
期刊:Journal Of Cellular Physiology
影响因子 :5.600
引用产品:CL-0105
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Parathyroid hormone alleviates non-alcoholic liver steatosis via activating the hepatic cAMP/PKA/CREB pathway.(2022/08/17)
作者:Xu Feng, Ye Xiao, Qi Guo
期刊:Frontiers in Endocrinology
影响因子 :5.200
引用产品:CL-0105
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Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment(2023/12/07)
作者:Pengfei Ren, Qingjuan Tang, Xinjia He
期刊:MOLECULAR NUTRITION & FOOD RESEARCH
影响因子 :5.200
引用产品:CL-0105
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Multi-omics study on the molecular mechanism of anlotinib in regulating tumor metabolism(2024/05/09)
作者:Yu Lu, Xuedan Han, Hongwei Zhang
期刊:EUROPEAN JOURNAL OF PHARMACOLOGY
DOI:10.1016/j.ejphar.2024.176639
影响因子 :5.000
引用产品:CL-0105
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Hepatic Symbiotic Bacterium L. reuteri FLRE5K1 Inhibits the Development and Progression of Hepatocellular Carcinoma via Activating the IFN-γ/CXCL10/CXCR3 Pathway(2023/06/08)
作者:Nan Zhang, Shuiwen Ye, Xinlu Wang
期刊:Probiotics and Antimicrobial Proteins
DOI:10.1007/s12602-023-10098-y
影响因子 :4.900
引用产品:CL-0105
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Insulin-like growth factor binding protein 3 gene of golden pompano (TroIGFBP3) promotes antimicrobial immune defense(2020/04/08)
作者:Yang Chen, Yongcan Zhou, Xiaoyu Yang
期刊:Fish & Shellfish Immunology
影响因子 :4.700
引用产品:CL-0105
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TroTNFSF6, a tumor necrosis factor ligand superfamily member, promotes antibacterial immune response of golden pompano, Trachinotus ovatus(2022/12/11)
作者:Chunsheng Liu, Lu Wang, Xiaojuan Chen
期刊:Fish & Shellfish Immunology
影响因子 :4.700
引用产品:CL-0105
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Decoding the complexity of on-target integration: characterizing DNA insertions at the CRISPR-Cas9 targeted locus using nanopore sequencing(2024/02/17)
作者:Juanjuan Zhao, Xinyu Sun, Saining Tian
期刊:BMC GENOMICS
DOI:10.1186/s12864-024-10050-6
影响因子 :4.400
引用产品:CL-0105
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Microwave ablation combined with anti-PD-1 therapy enhances systemic antitumor immunity in a multitumor murine model of Hepa1-6(2022/02/06)
作者:Songjiang Huang, Tongqiang Li, Yang Chen
期刊:International Journal Of Hyperthermia
DOI:10.1080/02656736.2022.2032406
影响因子 :3.100
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A Comparative Study of Antitumor Immunity Induced by Radiofrequency Microwave and Cryoablation in Hepatocellular Carcinoma(2023/10/27)
作者:Kai Zhang, Ming liu, Lin Cong
期刊:APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
DOI:10.1007/s12010-023-04760-y
影响因子 :3.000
引用产品:CL-0105
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