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产品概述
| 名称 | 3T3-L1 (小鼠胚胎成纤维细胞) (STR鉴定正确) |
| 别称 | 3T3 L1; 3T3L1; 3T3-L1 ad; NIH-3T3-L1; NIH3T3-L1 |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | 3T3-L1细胞是通过克隆分离得到的3T3(swiss小白鼠)的连续亚株。当3T3-L1细胞从快速分裂到长满且接触抑制时，3T3-L1细胞经过前脂肪向脂肪样逆转。培养液中，高血清含量可以促进3T3-L1细胞内脂肪的积累。 |
| 年龄（性别） | 胚胎 |
| 组织来源 | 胚胎 |
| 细胞类型 | 自发永生化细胞 |
| 生物安全等级 | BSL-1 |
| 受体表达情况 | insulin, expressed |
| 保藏机构 | ATCC; CL-173 ATCC; CCL-92.1BCRC; 60159 |
所用细胞：3T3-L1 (小鼠胚胎成纤维细胞) ；货号：CL-0006
细胞代次：复苏后P5代
所用诱导试剂：3T3-L1 (小鼠胚胎成纤维细胞) 成脂诱导分化培养基；货号：PD-031
STR鉴定
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STR位点信息
18-3 17,21 6-7 12,15 5-5 13,15 X-1 26 1-2 13 7-1 25.2,29 8-1 15,16 1-1 10,15 19-2 12 15-3 20.3 12-1 19 6-4 15.3 4-2 19.3 3-2 14 2-1 9 13-1 15.1
11-2 15 17-2 12,15 -
STR鉴定图
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参考文献
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Antitumor Effects of Carrier-Free Functionalized Lignin Materials on Human Hepatocellular Carcinoma (HepG2) Cells(2024/01/23)
作者：Yilin Wang, Zhiqiang Lu, Bin Liu
期刊：ACS Nano
影响因子 ：17.100
引用产品：CL-0006
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Myeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation in male mice(2024/01/02)
作者：Tian Su, Yue He, Yan Huang
期刊：Nature Communications
DOI：10.1038/s41467-023-43787-x
影响因子 ：16.600
引用产品：CL-0006
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Quercitrin alleviates lipid metabolism disorder in polycystic ovary syndrome-insulin resistance by upregulating PM20D1 in the PI3K/Akt pathway(2023/06/02)
作者：Meihe LI, Shan GAO, Minchao KANG
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.154908
影响因子 ：7.900
引用产品：CL-0006
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Blood cell repelling and tumor cell capturing surface for high-purity enrichment of circulating tumor cells(2019/10/16)
作者：Tong Li, Nan Li, Yao Ma
期刊：Journal of Materials Chemistry B
影响因子 ：7.571
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Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression(2023/04/04)
作者：Zhenhua Liu, Mengke Wang, Lijun Meng
期刊：Food Science and Human Wellness
DOI：10.1016/j.fshw.2023.03.015
影响因子 ：7.000
引用产品：CL-0006
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Silica-induced macrophage pyroptosis propels pulmonary fibrosis through coordinated activation of relaxin and osteoclast differentiation signaling to reprogram fibroblasts(2024/02/19)
作者：Jiaqi Tian, Dandan Song, Yanjie Peng
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2024.116106
影响因子 ：6.800
引用产品：CL-0006
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A confined crosslinking strategy towards an intelligent organosilica–micellar hybrid drug delivery system(2022/1/18)
作者：Xing Qin, Limei Qin, Jianping He
期刊：Biomaterials Science
影响因子 ：6.600
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Effects of two triterpenoids from Nigella sativa seeds on insulin resistance of 3T3-L1 adipocytes(2022/08/23)
作者：Jinfeng Wei, Baoguang Wang, Yixiao Chen
期刊：Frontiers in Nutrition
影响因子 ：6.590
引用产品：CL-0006
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Dual Regulation of Sulfonated Lignin to Prevent and Treat Type 2 Diabetes Mellitus(2023/01/06)
作者：Shuang Qi, Bo Jiang, Caoxing Huang
期刊：BIOMACROMOLECULES
DOI：10.1021/acs.biomac.2c01267
影响因子 ：6.200
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Shortening of HO1 3′UTRs by Alternative Polyadenylation Suppresses Adipogenesis in 3T3-L1(2021/07/08)
作者：Jianwei Cui, Chengping Li, Xiao Cui
期刊：Journal Of Agricultural And Food Chemistry
影响因子 ：6.100
引用产品：CL-0006
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Insights into metabolic characteristics and biological activity changes in Zangju (Citrus reticulata cv. Manau Gan) peel at different maturity stages through UPLC–MS/MS-based metabolomics(2024/02/05)
作者：Peng Wang, Haifan Wang, Yang Xiao
期刊：Food Chemistry-X
DOI：10.1016/j.fochx.2024.101197
影响因子 ：6.100
引用产品：CL-0006
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miR-34a Regulates Lipid Droplet Deposition in 3T3-L1 and C2C12 Cells by Targeting LEF1(2022/12/30)
作者：Lixue Wang, Yuhuai Xie, Wei Chen
期刊：Cells
影响因子 ：6.000
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A strategy for oral delivery of FGF21 for mitigating inflammation and multi-organ damage in sepsis(2024/04/12)
作者：Xinze Li, Dedong Yu, Xuanhe Chen
期刊：INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI：10.1016/j.ijpharm.2024.124115
影响因子 ：5.800
引用产品：CL-0006
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MCP-1-Loaded Poly(l-lactide-co-caprolactone) Fibrous Films Modulate Macrophage Polarization toward an Anti-inflammatory Phenotype and Improve Angiogenesis(2023/06/27)
作者：Can Cheng, Heng Li, Jingwen Liu
期刊：ACS Biomaterials Science & Engineering
DOI：10.1021/acsbiomaterials.3c00476
影响因子 ：5.800
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Baicalein enhances immune response in TNBC by inhibiting leptin expression of adipocytes(2023/07/25)
作者：Mengjie Liu, Chaofan Li, Jingkun Qu
期刊：CANCER SCIENCE
影响因子 ：5.700
引用产品：CL-0006
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FBXO28 reduces high-fat diet-induced hyperlipidemia in mice by alleviating abnormal lipid metabolism and inflammatory responses(2024/05/02)
作者：Sun J., Du B., Chen M.
期刊：JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
DOI：10.1007/s40618-024-02376-5
影响因子 ：5.400
引用产品：CL-0006
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Quinacrine attenuates diet-induced obesity by inhibiting adipogenesis via activation of AMPK signaling(2022/11/30)
作者：Xiangxiang Li, Jing Zhou, Zhuozhou Hu, Liang Han, Wenyang Zhao, Tongyu Wu, Chun Li, Jingjing Liu, Jia Kang, Xinping Chen
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2022.175432
影响因子 ：5.000
引用产品：CL-0006
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Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling(2024/01/24)
作者：Lulu Han, Xin Zhang, Hui Zhang
期刊：Journal of Integrative Medicine-JIM
DOI：10.1016/j.joim.2024.01.003
影响因子 ：4.800
引用产品：CL-0006
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Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton’s jelly-derived mesenchymal stem cells: a novel therapeutic approach(2024/04/16)
作者：Jing Cui, Mingkun Wang, Wenhong Zhang
期刊：Diabetology & Metabolic Syndrome
DOI：10.1186/s13098-024-01332-w
影响因子 ：4.800
引用产品：CL-0006
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Development of a Self-Assembled Hydrogels Based on Carboxymethyl Chitosan and Oxidized Hyaluronic Acid Containing Tanshinone Extract Nanocrystals for Enhanced Dissolution and Acne Treatment(2022/12/09)
作者：Xiaohan Tang, Yan Liu, Hailong Yuan
期刊：Pharmaceuticals
影响因子 ：4.600
引用产品：CL-0006
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Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway(2023/11/28)
作者：Long Cheng, Lu Shi, Changhao He
期刊：Chinese Journal of Natural Medicines
DOI：10.1016/S1875-5364(23)60481-9
影响因子 ：4.600
引用产品：CL-0006
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The role of RUNX1/NF-κB in regulating PVAT inflammation in aortic dissection(2024/04/30)
作者：Ao Wang, Shengjun Dong, Baohui Liu
期刊：Scientific Reports
DOI：10.1038/s41598-024-60737-9
影响因子 ：4.600
引用产品：CL-0006
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Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway(2024/04/24)
作者：Bihe Zeng, Qin Shen, Bo Wang
期刊：Nutrition & Metabolism
DOI：10.1186/s12986-024-00790-3
影响因子 ：4.500
引用产品：CL-0006
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Delivery of microRNA-423-5p by exosome from adipose-derived stem/stromal cells inhibits DVL3 to potentiate autologous fat graft survival through adipogenesis and inflammatory response(2023/12/02)
作者：Jinglin Zhu, Fangning Zhao, Yimeng Chai
期刊：Human Cell
DOI：10.1007/s13577-023-01010-5
影响因子 ：4.300
引用产品：CL-0006
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Icariin Inhibits AMPK-Dependent Autophagy and Adipogenesis in Adipocytes In vitro and in a Model of Graves Orbitopathy In vivo(2017/02/13)
作者：Hong Li, Yifei Yuan, Yali Zhang
期刊：Frontiers in Physiology
影响因子 ：4.000
引用产品：CL-0006
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Breast cancer cell-derived exosome-delivered microRNA-155 targets UBQLN1 in adipocytes and facilitates cancer cachexia-related fat loss(2023/04/05)
作者：Si Sun, Zhong Wang, Feng Yao
期刊：Human Molecular Genetics
影响因子 ：3.500
引用产品：CL-0006
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New iridoids from Patrinia scabiosaefolia and their hypoglycemic effects by activating PI3K/Akt signaling pathway(2023/01/03)
作者：Zhenhua Liu, Lijun Meng, Mengke Wang
期刊：FITOTERAPIA
DOI：10.1016/j.fitote.2022.105423
影响因子 ：3.400
引用产品：CL-0006
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Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway(2022/09/02)
作者：Jialin Sun, Ping Leng, Xiao Li
期刊：Adipocyte
DOI：10.1080/21623945.2022.2116790
影响因子 ：3.300
引用产品：CL-0006
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Potentilla bifurca flavonoids effectively improve insulin resistance(2022/11/30)
作者：G.-Y. Wang, P.-Y. Yan, W. Liu, L.-K. Liu, J.-P. Li, Y. Zeng
期刊：European Review for Medical and Pharmacological Sciences
DOI：10.26355/eurrev_202211_30370
影响因子 ：3.300
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Bovine C-X-C Motif Chemokine Ligand 14 Expression Is Regulated by Alternative Polyadenylation and MicroRNAs(2023/09/30)
作者：Wei Zhao, Xueyan Liu, Chengping Li
期刊：Animals
影响因子 ：3.000
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Effects of the CDC10 (Septin 7) Gene on the Proliferation and Differentiation of Bovine Intramuscular Preadipocyte and 3T3-L1 Cells(2023/02/09)
作者：Zixuan Cheng, Xihe Li, Siqin Bao
期刊：Animals
影响因子 ：3.000
引用产品：CL-0006
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Circadian rhythm disorders elevate macrophages cytokines release and promote multiple tissues/organs dysfunction in mice(2022/03/02)
作者：Zhen Sun, Lihua Li, Zhixin Yan
期刊：Physiol Behav
DOI：10.1016/j.physbeh.2022.113772
影响因子 ：2.900
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Chenodeoxycholic acid attenuates high‑fat diet‑induced obesity and hyperglycemia via the G protein‑coupled bile acid receptor 1 and proliferator‑activated receptor γ pathway(2017/10/29)
作者：Xiaosong Chen, Liu Yan, Zhihui Guo
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.700
引用产品：CL-0006
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Isolation and extraction of glansreginin A from walnut meal and its effect on the proliferation of 3T3-L1 cells(2023/04/03)
作者：Yongling Wu, Jiaxin Song, Aijin Ma
期刊：Food Science and Technology
影响因子 ：2.602
引用产品：CL-0006
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STUB1 increases adiponectin expression by inducing ubiquitination and degradation of NR2F2, thereby reducing hepatic stellate cell activation and alleviating non-alcoholic fatty liver disease(2024/03/02)
作者：Zheng Mao, Jindong Zhao, Fan Cui
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2024.102345
影响因子 ：2.600
引用产品：CL-0006
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Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity(2024/02/13)
作者：Guojin Liang, Jie Fang, Pingping Zhang
期刊：Open Medicine
影响因子 ：2.100
引用产品：CL-0006
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