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产品概述
| 名称 | A-375 (人恶性黑色素瘤细胞) (STR鉴定正确) |
| 别称 | A 375; A375; A375-MEL; A375-mel; A375mel |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | A-375细胞源自一位54岁女性，是由D·J·Giard等人建立的一系列细胞株中的一株。A-375细胞在抗胸腺细胞球蛋白、血清处理的NIH瑞士小鼠中形成类似于恶性黑素瘤的快速增长的皮下肿瘤；A-375在普通成纤维细胞和琼脂上形成克隆。 |
| 年龄（性别） | 女性；54岁 |
| 组织来源 | 皮肤；恶性黑色素瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 黑色素瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~24-32 hours |
| 致瘤性 | Yes, in immunosuppressed mice. |
| 保藏机构 | ATCC; CRL-1619 ATCC; CRL-7904BCRC; 60039 BCRJ; 0278 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 16,24 D3S1358 15,17 D5S818 12 D7S820 9 D8S1179 11,14 D13S317 11,14 D16S539 9 D18S51 12,17 D19S433 13,14.2 D21S11 29,30 FGA 23 PentaD 9,15 PentaE 10,12 TH01 8 TPOX 8,10 vWA 16,17 D6S1043 11,14 D12S391 18,21 D2S441 11 -
STR鉴定图
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参考文献
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D3S-001, a KRAS G12C inhibitor with rapid target engagement kinetics, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities(2024/05/08)
作者：Jing Zhang, Sunmin Lim, Mira Yu
期刊：Cancer Discovery
DOI：10.1158/2159-8290.CD-24-0006
影响因子 ：28.200
引用产品：CL-0014
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Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy(2023/08/22)
作者：Lin Li, Mengxing Zhang, Jing Li
期刊：Nature Communications
DOI：10.1038/s41467-023-40814-9
影响因子 ：16.600
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An enhanced cascade-based deep forest model for drug combination prediction(2022/03/10)
作者：Weiping Lin, Lianlian Wu, Yixin Zhang
期刊：Briefings In Bioinformatics
影响因子 ：13.994
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Multivalent DNA Flowers for High-Performance Isolation, Detection, and Release of Tumor-Derived Extracellular Vesicles(2023/11/26)
作者：Yongan Ren, Ke Ge, Wei Lu
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
引用产品：CL-0014
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A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression(2024/02/27)
作者：Yongrui Hai, Renming Fan, Ting Zhao
期刊：PHARMACOLOGICAL RESEARCH
DOI：10.1016/j.phrs.2024.107115
影响因子 ：9.300
引用产品：CL-0014
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Selective enrichment and detection of PD-L1 positive extracellular vesicles derived from human plasma and patient derived tumor cells(2022/11/28)
作者：Yongan Ren, Ke Ge, Wei Lu
期刊：SENSORS AND ACTUATORS B-CHEMICAL
影响因子 ：9.221
引用产品：CL-0014
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Dual Modal Imaging-Guided Drug Delivery System for Combined Chemo-Photothermal Melanoma Therapy(2021/05/18)
作者：Dong Zhang, Weifen Zhang, Xinghan Wu
期刊：International Journal of Nanomedicine
影响因子 ：8.000
引用产品：CL-0014
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Design, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5(2023/09/26)
作者：Pengming Pan, Tongtong Geng, Zhongtang Li
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c00864
影响因子 ：7.300
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Development and validation of ferroptosis-related lncRNA signature and immune-related gene signature for predicting the prognosis of cutaneous melanoma patients(2023/03/24)
作者：Kaifen Xiong, Zheng Wang, Hounye Alphonse Houssou
期刊：APOPTOSIS
DOI：10.1007/s10495-023-01831-7
影响因子 ：7.200
引用产品：CL-0014
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RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma(2023/06/30)
作者：Yanan Guo, Rong Shen, Keren Yang
期刊：Cell Death Discovery
DOI：10.1038/s41420-023-01500-3
影响因子 ：7.000
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Heating conversion of indole-3-carbinol into N-substituted oligomers with anti-melanoma effect(2024/04/24)
作者：Jiacheng Qian, Hengpeng Zhang, Yi Wang
期刊：Food Chemistry-X
DOI：10.1016/j.fochx.2024.101410
影响因子 ：6.100
引用产品：CL-0014
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Evaluation of the Effect of Fibroblasts on Melanoma Metastasis Using a Biomimetic Co-Culture Model(2023/04/07)
作者：Miaoben Wu, Enxing Yu, Kai Ye
期刊：ACS Biomaterials Science & Engineering
DOI：10.1021/acsbiomaterials.2c01186
影响因子 ：5.800
引用产品：CL-0014
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Promotion of Melanoma Cell Proliferation by Cyclic Straining through Regulatory Morphogenesis(2022/10/06)
作者：Siyuan Huang, Zhu Chen, Xiaoqiang Hou
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
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Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with Fe3O4 Particles for Killing A375 Melanoma Cells(2024/04/26)
作者：Yan Mi, Mengnan Zhang, Chi Ma
期刊：Biomolecules
影响因子 ：5.500
引用产品：CL-0014
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Cytotoxic and Antibacterial Meroterpenoids Isolated from the Marine-Derived Fungus Talaromyces sp. M27416(2024/04/20)
作者：Lingzhi Tang, Jinmei Xia, Zhongwei Chen
期刊：Marine Drugs
影响因子 ：5.400
引用产品：CL-0014
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YY1-induced lncRNA00511 promotes melanoma progression via the miR-150-5p/ADAM19 axis(2024/02/15)
作者：Yani Chen, Xinrui Fu, Hua Guo
期刊：American Journal of Cancer Research
DOI：PMID:38455406
影响因子 ：5.300
引用产品：CL-0014
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Structures and antitumor activities of ten new and twenty known surfactins from the deep-sea bacterium Limimaricola sp. SCSIO 53532( 2021/12/31)
作者：Wenping Ding, Yanqun Li, Min Chen
期刊： BIOORGANIC CHEMISTRY
DOI：10.1016/j.bioorg.2021.105589
影响因子 ：5.100
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Identification and characterization of two novel non-coding Tyrosinase (TYR) gene variants leading to Oculocutaneous albinism type 1(2022/04/10)
作者：Chaoyi Li, Qian Chen, Junjiao Wu
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 ：4.800
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PTPRC functions as a prognosis biomarker in the tumor microenvironment of cutaneous melanoma(2023/11/23)
作者：Xuemei Li, Zhanghui Yue, Dan Wang
期刊：Scientific Reports
DOI：10.1038/s41598-023-46794-6
影响因子 ：4.600
引用产品：CL-0014
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Envoplakin Inhibits Macrophage Polarization by Altering the Inflammatory Tumor Microenvironment of Melanoma Through the RAS / ERK Signaling Pathway(2024/03/14)
作者：Weilin Cai, Minliang Chen
期刊：Journal of Inflammation Research
影响因子 ：4.500
引用产品：CL-0014
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LRRK2 correlates with macrophage infiltration in pan-cancer( 2021/12/18)
作者：Jing Yan, Wenhui Zhao, Wei Yu
期刊：Genomics
DOI：10.1016/j.ygeno.2021.11.037
影响因子 ：4.400
引用产品：CL-0014
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Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling(2021/05/28)
作者：Ruiqi Xu, Mengnan Zeng, Yuanyuan Wu
期刊：OncoTargets and Therapy
影响因子 ：4.345
引用产品：CL-0014
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MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14(2023/11/20)
作者：Gege Li, Changlong Zhou, Lu Wang
期刊：Pigment Cell & Melanoma Research
影响因子 ：4.300
引用产品：CL-0014
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LPCAT1 promotes melanoma cell proliferation via Akt signaling(2024/03/26)
作者：Yuqian Wang, Yingjian Huang, Yan Wang
期刊：ONCOLOGY REPORTS
影响因子 ：4.200
引用产品：CL-0014
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A new amide alkaloid induces the apoptosis of human melanoma A375 cells via inhibition of the STAT3 signaling pathway(2022/11/16)
作者：Ru Wang, Bo Yang, Beibei Zhang
期刊：NEW JOURNAL OF CHEMISTRY
影响因子 ：3.925
引用产品：CL-0014
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Preliminary Exploration of the Biophysical Mechanisms of Pulsed Magnetic Field-Induced Cell Permeabilization(2024/04/16)
作者：Chi Ma, Mengnan Zhang, Fei Teng
期刊：IEEE TRANSACTIONS ON NANOBIOSCIENCE
影响因子 ：3.900
引用产品：CL-0014
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A Machine Learning Method for Drug Combination Prediction(2020/08/25)
作者：Jiang Li, Xinyu Tong, Lida Zhu
期刊：Frontiers in Genetics
影响因子 ：3.700
引用产品：CL-0014
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Immune infiltration and clinical significance analyses of the cancer-associated fibroblast-related signature in skin cutaneous melanoma(2023/10/17)
作者：Xintao Cen, Mengna Li, Amin Yao
期刊：JOURNAL OF GENE MEDICINE
DOI：10.1002/jgm.3614
影响因子 ：3.500
引用产品：CL-0014
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CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression(2022/12/15)
作者：Xuerui Geng, Xiujuan Qiu, Jun Gao
期刊：BMC Molecular and Cell Biology
DOI：10.1186/s12860-022-00446-1
影响因子 ：2.800
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LSM2 is associated with a poor prognosis and promotes cell proliferation, migration, and invasion in skin cutaneous melanoma(2023/06/13)
作者：Xiaofang Sun, Jianping Zhang, Jiayuan Hu
期刊：BMC Medical Genomics
DOI：10.1186/s12920-023-01564-1
影响因子 ：2.700
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The Antitumor Potential of Extract of the Oak Bracket Medicinal Mushroom Inonotus baumii in SMMC-7721 Tumor Cells(2019/9/22)
作者：Yue Yang, Pingya He, Ning Li
期刊：Evidence-based Complementary and Alternative Medicine
影响因子 ：2.650
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LncRNA FENDRR Suppresses Melanoma Growth via Influencing c-Myc mRNA Level(2023/08/08)
作者：Changying Niu, Shenxing Tan
期刊：Clinical Cosmetic and Investigational Dermatology
影响因子 ：2.300
引用产品：CL-0014
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Extraction and Separation of Sinapine from Rapeseed Cake and the Mode of Action of Melanin Production Inhibition(2021/1/5)
作者：Z. T. Yang, D. X. Lu, E.-K. Hong
期刊：Molecular Biology
影响因子 ：1.200
引用产品：CL-0014
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Human EVI2B acts as a Janus-faced oncogene/antioncogene by differently affecting as per cancer type neoplastic cells growth and immune infiltration:(2023/03/23)
作者：Fangyingnan Zhang, Xinning Wang, Xiaoqi Zhang
期刊：Oncologie
DOI：10.1515/oncologie-2022-1002
影响因子 ：0.900
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The Krüppel-like factor 6 represses proliferation and invasion of cutaneous malignant melanoma(2023/10/25)
作者：Yuanyuan Li, Qiming Zheng, Nan Zhang
期刊：POLISH JOURNAL OF PATHOLOGY
影响因子 ：0.800
引用产品：CL-0014
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Naringin suppresses the metabolism of A375 cells by inhibiting the phosphorylation of c-Src(2015/10/17)
作者：Bingyu Guo, Yu Zhang, Qiang Hui
期刊：Tumor Biology
影响因子 ：0.000
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