产品中心Cell Resources
联系我们CONTACT US
400-999-210024小时服务热线
产品概述
| 名称 | HT-29 (人结肠癌细胞) (STR鉴定正确) |
| 别称 | HT 29; HT29 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | HT-29细胞是由J·Fogh在1964年用移植培养方法和含15%FBS的F12培养液从原发性肿瘤分离的；近来，已建株的培养细胞用含相同血清McCoy's5A培液培养。HT-29细胞在裸鼠中致瘤，也能在类固醇处理的地鼠中致瘤。HT-29细胞合成IgA、CEA、蛋白绑定TGF-β的分泌成分和粘液素等。 |
| 年龄（性别） | 女性；44岁 |
| 组织来源 | 结直肠腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肠癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~36-60 hours |
| 致瘤性 | Yes, in nude mice; forms well differentiated adenocarcinoma consistent with colonic primary (grade I); tumors also form in steroid treated hamsters. |
| 受体表达情况 | human adrenergic alpha2A, urokinase receptor (u-PAR), vitamin D (moderate expression), urokinase receptor (u-PAR); vitamin D (moderate expression), human adrenergic alpha2A |
| 基因表达情况 | secretory component of IgA; carcinoembryonic antigen (CEA); transforming growth factor beta binding protein; mucin, myc+; ras+; myb+; fos+; sis+; p53+; abl -; ros -; src -, Blood Type A; Rh+; HLA A1, A3, B12, B17, Cw5, HT-29 cells are negative for CD4, but there is cell surface expression of galactose ceramide (a possible alternative receptor for HIV). |
| 保藏机构 | ATCC; HTB-38 BCRJ; 0111 CCLV; CCLV-RIE 0960 DSMZ; ACC-299 ECACC; 91072201 |
STR鉴定
-
STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 19,23 D3S1358 15,17 D5S818 11,12 D7S820 10 D8S1179 10,16 D13S317 11,12 D16S539 11,12 D18S51 13 D19S433 14 D21S11 29,30 FGA 20,22 PentaD 11,13 PentaE 14,16 TH01 6,9 TPOX 8,9 vWA 17,19 D6S1043 12,14 D12S391 18.3,21 D2S441 11 -
STR鉴定图
-
参考文献
-
SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip(2020/12/01)
作者：Yaqiong Guo, Ronghua Luo, Yaqing Wang
期刊：Science Bulletin
DOI：10.1016/j.scib.2020.11.015
影响因子 ：18.900
引用产品：CL-0118
-
Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease(2024/05/13)
作者：Yang Yu, Dairong Yang, Bingru Lin
期刊：ACS Nano
影响因子 ：17.100
引用产品：CL-0118
-
Bacteria-Induced Colloidal Encapsulation for Probiotic Oral Delivery(2023/03/22)
作者：Chong Zhang, Xiaorong Gao, Xinxiu Ren
期刊：ACS Nano
影响因子 ：17.100
-
Mitochondrial genome transfer drives metabolic reprogramming in adjacent colonic epithelial cells promoting TGFβ1-mediated tumor progression(2024/04/30)
作者：Bingjie Guan, Youdong Liu, Bowen Xie
期刊：Nature Communications
DOI：10.1038/s41467-024-48100-y
影响因子 ：16.600
引用产品：CL-0118
-
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer(2022/08/28)
作者：Meng Tang, Hui Xu, Hongyan Huang
期刊：Advanced Science
影响因子 ：15.100
引用产品：CL-0118
-
Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis(2024/01/17)
作者：Can Cheng, Hanhui Yao, Heng Li
期刊：Acta Pharmaceutica Sinica B
DOI：10.1016/j.apsb.2024.01.006
影响因子 ：14.500
引用产品：CL-0118
-
An enhanced cascade-based deep forest model for drug combination prediction(2022/03/10)
作者：Weiping Lin, Lianlian Wu, Yixin Zhang
期刊：Briefings In Bioinformatics
影响因子 ：13.994
-
Nitroreductase-instructed supramolecular assemblies for microbiome regulation to enhance colorectal cancer treatments(2022/11/09)
作者：Jiali Chen, Pai Zhang, Yan Zhao, Jie Zhao, Xiaobo Wu, Ruijia Zhang, Ruitao Cha, Qingxin Yao, Yuan Gao
期刊：Science Advances
影响因子 ：13.600
引用产品：CL-0071 CL-0096 CL-0101 CL-0118 PM150110 PM150210 PM150710
-
Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA(2022/12/15)
作者：Chi Jin, Tuo Wang, Dongsheng Zhang
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02551-7
影响因子 ：11.300
-
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation(2021/10/26)
作者：Yan Li, Na Zhang, Chao Ma
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-04289-0
影响因子 ：9.000
引用产品：CL-0118
-
A possible but unrecognized risk of acceptable daily intake dose triazole pesticides exposure—bile acid disturbance induced pharmacokinetic changes of oral medication(2023/02/21)
作者：Yujing Xu, Yufeng Zhang, Quan Tao
期刊：CHEMOSPHERE
DOI：10.1016/j.chemosphere.2023.138209
影响因子 ：8.800
-
USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential(2023/08/22)
作者：Yinuo Wang, Aihua Mao, Jingwei Liu
期刊：Cell Chemical Biology
DOI：10.1016/j.chembiol.2023.07.016
影响因子 ：8.600
引用产品：CL-0118
-
Anti-colon cancer effects of Spirulina polysaccharide and its mechanism based on 3D models(2022/12/26)
作者：Yingfang Lu, Zexin Chen, Qianmin Lin
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2022.12.244
影响因子 ：8.200
-
Formyl peptide receptor 1 mitigates colon inflammation and maintains mucosal homeostasis through the inhibition of CREB-C/EBPβ-S100a8 signaling(2024/04/15)
作者：Tingting Li, Xiaojun Zhou, Qian Zhang
期刊：Mucosal Immunology
DOI：10.1016/j.mucimm.2024.04.001
影响因子 ：8.000
引用产品：CL-0118
-
Targeted EpCAM-binding for the development of potent and effective anticancer proteins(2023/02/28)
作者：Zhao Liu, Chen Zhang, Beiming Cui
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2023.114443
影响因子 ：7.500
-
Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy(2021/07/20)
作者：Dandan Wang, Shuai Shao, Yanqiu Zhang
期刊：Frontiers in Immunology
影响因子 ：7.300
引用产品：CL-0118
-
USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer(2023/08/03)
作者：Yunli Chang, Lingling Chen, Jie Tang
期刊：CELL BIOLOGY AND TOXICOLOGY
DOI：10.1007/s10565-023-09822-9
影响因子 ：6.100
-
Indole-3-propionic Acid Improved the Intestinal Barrier by Enhancing Epithelial Barrier and Mucus Barrier(2020/12/23)
作者：Jiaojiao Li, Li Zhang, Tao Wu
期刊：Journal Of Agricultural And Food Chemistry
影响因子 ：6.100
-
Identification and validation of a novel prognosis model based on m5C-related long non-coding RNAs in colorectal cancer(2023/09/05)
作者：Ziyang Di, Gaoran Xu, Zheyu Ding
期刊：Cancer Cell International
DOI：10.1186/s12935-023-03025-2
影响因子 ：5.800
-
SEDDS facilitate cinnamaldehyde crossing the mucus barrier: The perspective of mucus and Caco-2/HT29 co-culture models(2022/01/10)
作者：Ye Cai, Liu Liu, Mengqiu Xia
期刊：International Journal Of Pharmaceutics
DOI：10.1016/j.ijpharm.2022.121461
影响因子 ：5.800
-
LncRNA-ENST00000543604 exerts a tumor-promoting effect via miRNA 564/AEG-1 or ZNF326/EMT and predicts the prognosis of and chemotherapeutic effect in colorectal cancer.(2022/08/23)
作者：Weimin Wang, Zhen Zhou, Xiaojun Dai
期刊：Frontiers in Oncology
影响因子 ：5.738
引用产品：CL-0118
-
A Genetic Algorithm-Based Ensemble Learning Framework for Drug Combination Prediction(2023/06/11)
作者：Lianlian Wu, Xiaona Ye, Yixin Zhang
期刊：Journal of Chemical Information and Modeling
影响因子 ：5.600
引用产品：CL-0118
-
Gentianine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibition of TLR4/NLRP3-mediated pyroptosis(2023/11/17)
作者：Yunxia Li, Lei Lv, Shaoliang Li
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111214
影响因子 ：5.600
引用产品：CL-0118
-
Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells(2023/03/12)
作者：Hao Kuang, Xuehua Sun, Ying Liu
期刊：FEBS Journal
影响因子 ：5.400
-
Qingchang Wenzhong Decoction ameliorates intestinal inflammation and intestinal barrier dysfunction in ulcerative colitis via the GC-C signaling pathway(2023/12/01)
作者：Yang Zhang, Junxiang Li, Xiao Han
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.400
引用产品：CL-0118
-
The traditional herb Sargentodoxa cuneata alleviates DSS-induced colitis by attenuating epithelial barrier damage via blocking necroptotic signaling(2023/11/03)
作者：Yuanyuan Chen, Zheng Song, Xiaorong Hou
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.400
引用产品：CL-0118
-
Quercetin-induced pyroptosis in colon cancer through NEK7-mediated NLRP3 inflammasome-GSDMD signaling pathway activation(2024/03/15)
作者：Shihan Feng, Bin Zhao, Xue Zhan
期刊：American Journal of Cancer Research
影响因子 ：5.300
引用产品：CL-0118
-
KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling(2023/09/13)
作者：Yuan Liu, Ming Sun, Bin Zhang
期刊：Aging-US
影响因子 ：5.200
引用产品：CL-0118
-
Identification of differentially expressed HERV-K(HML-2) loci in colorectal cancer(2023/06/05)
作者：Qian Kang, Xin Guo, Tianfu Li
期刊：Frontiers in Microbiology
DOI：10.3389/fmicb.2023.1192900
影响因子 ：5.200
引用产品：CL-0118
-
Exosomal circCOL1A2 from cancer cells accelerates colorectal cancer progression via regulating miR-665/LASP1 signal axis(2023/04/12)
作者：Zhi Miao, Xiaomeng Zhao, Xiang Liu
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.175722
影响因子 ：5.000
-
MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2(2021/10/16)
作者：Bo Li, Xianyi Liu, Guogang Wu
期刊：Bioengineered
DOI：10.1080/21655979.2021.1996505.
影响因子 ：4.900
-
Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition(2020/07/10)
作者：Yan Lin, Moussa Harouna Koumba, Suxuan Qu
期刊：Cellular Signalling
DOI：10.1016/j.cellsig.2020.109707
影响因子 ：4.800
-
Colorectal cancer with low SLC35A3 is associated with immune infiltrates and poor prognosis(2024/01/03)
作者：Shuai Lu, Xibo Sun, Huazhen Tang
期刊：Scientific Reports
DOI：10.1038/s41598-023-51028-w
影响因子 ：4.600
引用产品：CL-0118
-
Identification of KIF21B as a Biomarker for Colorectal Cancer and Associated with Poor Prognosis(2022/11/21)
作者：Shanshan Xu, Youran Li, Hua Huang, Xian Miao, Yunfei Gu
期刊：Journal of Oncology
影响因子 ：4.501
-
Neutrophil-to-lymphocyte ratio in colorectal tissue affects prognosis in patients with colorectal cancer(2024/05/15)
作者：Feng Xun, Wenliang Jiang, Min Sha
期刊：PATHOLOGY
DOI：10.1016/j.pathol.2024.03.003
影响因子 ：4.500
引用产品：CL-0118
-
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition(2022/10/31)
作者：Lianjie Lin, Dongxu Wang, Suxuan Qu
期刊：Drug Design Development and Therapy
影响因子 ：4.319
引用产品：CL-0118
-
IL-22 promotes occludin expression by activating autophagy and treats ulcerative colitis(2023/07/13)
作者：Hui Nong, Haifeng Yuan, Yiting Lin
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-023-04806-z
影响因子 ：4.300
引用产品：CL-0118
-
Annexin A9 promotes cell proliferation by regulating the Wnt signaling pathway in colorectal cancer(2023/06/22)
作者：Xuemei Lu, Liqiang Hu, Jiayan Mao
期刊：Human Cell
DOI：10.1007/s13577-023-00939-x
影响因子 ：4.300
-
Oct4 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in colon cancer cells by activating the SCF/c-Kit signaling pathway(2022/10/18)
作者：Xiaoqian Bu, Yulong Liu, Lin Wang
期刊：CELL CYCLE
DOI：10.1080/15384101.2022.2112486
影响因子 ：4.300
-
Overexpression of ZNF169 promotes the growth and proliferation of colorectal cancer cells via the upregulation of ANKZF1(2024/04/23)
作者：Jie Zhang, Ye Wang, Shiyang Hou
期刊：ONCOLOGY REPORTS
影响因子 ：4.200
引用产品：CL-0118
-
A deep learning approach for the detection and counting of colon cancer cells (HT-29 cells) bunches and impurities(2023/12/05)
作者：Inayatul Haq, Tehseen Mazhar, Rizwana Naz Asif
期刊：PeerJ Computer Science
影响因子 ：3.800
引用产品：CL-0118
-
10-Secocycloartane (=9,19-cyclo-9,10-secolanostane) triterpenoid saponins: Huangqiyenins M–X from Astragalus membranaceus (Fisch.) Bge(2024/03/30)
作者：Mengqi Yan, Feng Xu, Haixue Kuang
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2024.114072
影响因子 ：3.800
引用产品：CL-0118
-
Label-free classification of dead and live colonic adenocarcinoma cells based on 2D light scattering and deep learning analysis(2021/6/19)
作者：Shuaiyi Li, Ya Li, Jianning Yao
期刊：Cytometry Part A
影响因子 ：3.700
引用产品：CL-0118
-
P300 increases CSNK2A1 expression which accelerates colorectal cancer progression through activation of the PI3K-AKT-mTOR axis(2023/06/28)
作者：Jilong Liu
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2023.113694
影响因子 ：3.700
-
The bromodomain and extra-terminal domain inhibitor JQ1 synergistically sensitizes human colorectal cancer cells to topoisomerase I inhibitors through repression of Mre11-mediated DNA repair pathway(2020/09/26)
作者：Linping Lei, Xuqin Xie, Long He
期刊：Investigational New Drugs
DOI：10.1007/s10637-020-01014-0
影响因子 ：3.400
-
Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model(2021/2/17)
作者：Qinghui Jia, Haihua Zhang, Yongmei Su
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-021-00796-y
影响因子 ：3.400
引用产品：CL-0118
-
Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy(2022/01/10)
作者：Haihua Zhang , Wuying Lang , Xin Liu
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-021-00854-5
影响因子 ：3.400
引用产品：CL-0118
-
PEX26 Functions as a Metastasis Suppressor in Colorectal Cancer(2023/11/13)
作者：Bianbian Yan, Lichao Cao, Liyang Gao
期刊：DIGESTIVE DISEASES AND SCIENCES
DOI：10.1007/s10620-023-08168-w
影响因子 ：3.100
引用产品：CL-0118
-
CAMK2N1 has a cancer-suppressive function in colorectal carcinoma via effects on the Wnt/β-catenin pathway(2022/08/15)
作者：Xiaolong Zhang, Lifei Tian, Zeyu Li
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2022.08.036
影响因子 ：3.100
-
Osthole induces apoptosis of the HT-29 cells via endoplasmic reticulum stress and autophagy(2021/8/10)
作者：Xinghua Zhou, Jian Kang, Zhendong Zhong
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0118
-
Colorectal cancer cells with stably expressed SIRT3 demonstrate proliferating retardation by Wnt/β-catenin cascade inactivation(2024/04/15)
作者：Tianyu Li, Leqi Fan, Yijiang Jia
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子 ：2.900
引用产品：CL-0118
-
Tanshinone IIA May Inhibit Gastric Cancer via Affecting the Intestinal Microbiome(2022/09/26)
作者：Fenggang Lu, Yi Zhang, Pinghui Song
期刊：Computational and Mathematical Methods in Medicine
影响因子 ：2.809
引用产品：CL-0118
-
Anti-cancer effects of Porphyra haitanensis polysaccharides on human colon cancer cells via cell cycle arrest and apoptosis without causing adverse effects in vitro(2020/8/11)
作者：WanZi Yao, Suresh Veeraperumal, HuaMai Qiu
期刊：3 BIOTECH
DOI：10.1007/s13205-020-02379-y
影响因子 ：2.800
-
RNF114 facilitates the proliferation, stemness, and metastasis of colorectal cancer(2023/07/27)
作者：Shicheng Liu, Lelan Gong, Fengchang Huang
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.800
-
Circ_0087862 promotes tumorigenesis and glycolysis in colorectal cancer by sponging miR-296-3p to regulate PGK1 expression(2023/07/17)
作者：Weisheng Xiao, Peiyuan Li
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.800
-
Culturable Diversity and Biological Properties of Bacterial Endophytes Associated with the Medicinal Plants of Vernonia anthelmintica (L.) Willd(2023/08/30)
作者：Litao Niu, Nigora Rustamova, Paiziliya Paerhati
期刊：Applied Sciences-Basel
影响因子 ：2.700
引用产品：CL-0118
-
circASS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells by regulating the miR‑1269a/VASH1 axis(2021/08/10)
作者：HaiLin Xiong, XiaoHua Zhong, XiaoHong Guo
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.700
-
ISLR affects colon cancer progression by regulating the epithelial–mesenchymal transition signaling pathway(2022/01/01)
作者：Chunhua Chi, Tongming Liu, Shengnan Yang
期刊：Anti-Cancer Drugs
DOI：10.1097/CAD.0000000000001233
影响因子 ：2.300
-
NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer(2023/02/27)
作者：Hong Yang, Leilei Pu, Ruobing Li
期刊：Journal of Gastrointestinal Oncology
影响因子 ：2.100
-
The Upregulation of GSTO2 is Associated with Colon Cancer Progression and a Poor Prognosis(2023/01/11)
作者：Xingyu Peng, Jinfeng Zhu, Sicheng Liu
期刊：Journal of Oncology
影响因子 ：0.000
-
Investigation of the Effects of Glabridin on the Proliferation, Apoptosis, and Migration of the Human Colon Cancer Cell Lines SW480 and SW620 and Its Mechanism Based on Reverse Virtual Screening and Proteomics(2023/01/05)
作者：Tingting Li, Hang Li, Wenxin Xia
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.000
FAQs
Q：{{item.question}}
A：
产品资料
识别码示意图
